Diffuse Large B-cell Lymphoma Presenting with Protein-losing Enteropathy during Treatment for Systemic Lupus Erythematosus
Abstract
Protein-losing enteropathy (PLE) is a rare complication of systemic lupus erythematosus (SLE). A 38-year-old woman with well-controlled SLE developed abdominal pain, lower-extremity edema, anemia, and hypoalbuminemia. The patient was then diagnosed with PLE. Despite treatment with glucocorticoids and cyclophosphamide, persistent hypoalbuminemia was observed. A biopsy was performed using double-balloon enteroscopy due to small bowel lesions, which confirmed the diagnosis of diffuse large B-cell lymphoma. To the best of our knowledge, this is the first reported case of diffuse large B-cell lymphoma mimicking PLE associated with SLE. The possibility of malignant lymphoma should be considered in cases of treatment-resistant PLEs associated with SLE.
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BibTeX
@article{yasui2026diffuse,
title = {{Diffuse Large B-cell Lymphoma Presenting with Protein-losing Enteropathy during Treatment for Systemic Lupus Erythematosus}},
author = {Shintaro Yasui and Keisuke Nishimura and Yukina Tanimoto and Michio Mugitani and Tenyu Sugano and Marianne Linley Sy-Janairo and Daisuke Watanabe and Rina Sakai and Hirotaka Yamada and Jun Saegusa},
journal = {Internal Medicine},
year = {2026},
month = aug,
doi = {10.2169/internalmedicine.5934-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/16/65_5934-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Diffuse Large B-cell Lymphoma Presenting with Protein-losing Enteropathy during Treatment for Systemic Lupus Erythematosus
AU - Shintaro Yasui
AU - Keisuke Nishimura
AU - Yukina Tanimoto
AU - Michio Mugitani
AU - Tenyu Sugano
AU - Marianne Linley Sy-Janairo
AU - Daisuke Watanabe
AU - Rina Sakai
AU - Hirotaka Yamada
AU - Jun Saegusa
PY - 2026
DA - 2026/08/15
JO - Internal Medicine
DO - 10.2169/internalmedicine.5934-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/16/65_5934-25/_article
AB - Protein-losing enteropathy (PLE) is a rare complication of systemic lupus erythematosus (SLE). A 38-year-old woman with well-controlled SLE developed abdominal pain, lower-extremity edema, anemia, and hypoalbuminemia. The patient was then diagnosed with PLE. Despite treatment with glucocorticoids and cyclophosphamide, persistent hypoalbuminemia was observed. A biopsy was performed using double-balloon enteroscopy due to small bowel lesions, which confirmed the diagnosis of diffuse large B-cell lymphoma. To the best of our knowledge, this is the first reported case of diffuse large B-cell lymphoma mimicking PLE associated with SLE. The possibility of malignant lymphoma should be considered in cases of treatment-resistant PLEs associated with SLE.
SN - 1349-7235
SN - 0918-2918
ER -