The miR-166a-3p in exosome-like nanoparticles from Stellera chamaejasme induce insecticidal effects in fall armyworm by disrupting the gut barrier and microbiota
- 1Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering and Technology Research Center of Coarse Cereal Industrialization, College of Food and Biological Engineering, Chengdu University , ,
- 2School of Agriculture and Food Sustainability, The University of Queensland , , ,
Abstract
Plant-derived exosome-like nanoparticles (ELNs) are a class of extracellular vesicles that have been shown to exert cross-species regulatory effects. This provides a new strategy for discovering novel insecticidal components in plants. In our study, the Stellera chamaejasme -derived exosome-like nanoparticles (Sc-ELNs) were first isolated and characterized. The insecticidal activity assays showed that the Sc-ELNs and miRNAs in it both exhibit inhibitory activity against fall armyworm (FAW) in vivo . It is worth noting that miR-166a-3p agomir can affect the food digestive absorption function of FAW by inducing apoptosis of intestinal epithelial cells and reducing the abundance of gut bacteria associated with polysaccharide utilization. Concurrently, multiple tricarboxylic acid (TCA) cycle-related pathways in bacteria were inhibited by miR-166a-3p agomir. Overall, this study demonstrates that Sc-ELNs and miR-166a-3p in it possess potential insecticidal effect, which provided a new pesticidal perspective for S. chamaejasme .
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BibTeX
@article{zhang2026mir166a3p,
title = {{The miR-166a-3p in exosome-like nanoparticles from Stellera chamaejasme induce insecticidal effects in fall armyworm by disrupting the gut barrier and microbiota}},
author = {Liwei Zhang and Teng Zhao and Lidan Lu and Ruyi Li and Wentao Gu and Liang Zou and Lianxin Peng and Kayvan Etebari and Yuanhang Ren},
journal = {Frontiers in plant science},
year = {2026},
month = sep,
doi = {10.3389/fpls.2026.1902418},
url = {https://europepmc.org/article/PMC/PMC13661944},
note = {CC BY},
}
RIS
TY - JOUR
TI - The miR-166a-3p in exosome-like nanoparticles from Stellera chamaejasme induce insecticidal effects in fall armyworm by disrupting the gut barrier and microbiota
AU - Liwei Zhang
AU - Teng Zhao
AU - Lidan Lu
AU - Ruyi Li
AU - Wentao Gu
AU - Liang Zou
AU - Lianxin Peng
AU - Kayvan Etebari
AU - Yuanhang Ren
PY - 2026
DA - 2026/09/30
JO - Frontiers in plant science
DO - 10.3389/fpls.2026.1902418
UR - https://europepmc.org/article/PMC/PMC13661944
AB - Plant-derived exosome-like nanoparticles (ELNs) are a class of extracellular vesicles that have been shown to exert cross-species regulatory effects. This provides a new strategy for discovering novel insecticidal components in plants. In our study, the Stellera chamaejasme -derived exosome-like nanoparticles (Sc-ELNs) were first isolated and characterized. The insecticidal activity assays showed that the Sc-ELNs and miRNAs in it both exhibit inhibitory activity against fall armyworm (FAW) in vivo . It is worth noting that miR-166a-3p agomir can affect the food digestive absorption function of FAW by inducing apoptosis of intestinal epithelial cells and reducing the abundance of gut bacteria associated with polysaccharide utilization. Concurrently, multiple tricarboxylic acid (TCA) cycle-related pathways in bacteria were inhibited by miR-166a-3p agomir. Overall, this study demonstrates that Sc-ELNs and miR-166a-3p in it possess potential insecticidal effect, which provided a new pesticidal perspective for S. chamaejasme .
SN - 1664-462X
ER -