Hypertension, Deep Retinal Perfusion, and Concurrent Visual Acuity in Retinal Vein Occlusion: A Cross-Sectional OCTA Study.
- 1Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, People's Republic of China.
Abstract
Background
To investigate the cross-sectional association between hypertension and OCTA-derived retinal microvascular characteristics and to assess whether deep capillary plexus perfusion area (DCP-PA) provides additional explanatory information for concurrent visual acuity in retinal vein occlusion (RVO).Methods
This retrospective secondary cross-sectional analysis included 88 RVO-affected eyes from 88 patients. Best-corrected visual acuity (BCVA) and swept-source OCTA were assessed at the same visit. Multivariable linear regression evaluated associations between hypertension and six OCTA outcomes after adjustment for age, sex, RVO subtype, and hyperlipidemia, with Benjamini-Hochberg false-discovery-rate (FDR) correction. The association between DCP-PA and concurrent logMAR BCVA was assessed using a clinical-structural model including age, sex, RVO subtype, hypertension, hyperlipidemia, and total retinal thickness (TRT), followed by an extended model incorporating DCP-PA.Results
Hypertension was associated with lower DCP-PA (β=-1.71; 95% CI, -2.85 to -0.57; FDR-adjusted P=0.011) and lower DCP vessel length density (β=-3.29; 95% CI, -5.48 to -1.09; FDR-adjusted P=0.011). Lower DCP-PA remained independently associated with worse concurrent visual acuity after adjustment for clinical factors and TRT (β=-0.12 per mm²; 95% CI, -0.16 to -0.08; P<0.001). Hyperlipidemia was also associated with worse visual acuity (β=0.34; 95% CI, 0.18 to 0.49; P<0.001). Adding DCP-PA increased adjusted R ² from 0.40 to 0.59 and reduced AIC from 94.60 to 61.99 (partial F=38.54; P<0.001). No significant interaction was observed between DCP-PA and RVO subtype (P=0.353).Conclusions
Hypertension was associated with reduced deep retinal perfusion in RVO. Lower DCP-PA was independently associated with worse concurrent visual acuity and provided additional explanatory information beyond clinical factors and retinal thickness. These cross-sectional findings do not establish causality or prospective prognostic value.
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BibTeX
@article{zhan2026hypertension,
title = {{Hypertension, Deep Retinal Perfusion, and Concurrent Visual Acuity in Retinal Vein Occlusion: A Cross-Sectional OCTA Study.}},
author = {Jinlian Zhan and Yanting Lai and Haichun Li and Lin Lu and Xiujuan Zhao},
journal = {Clinical ophthalmology (Auckland, N.Z.)},
year = {2026},
month = oct,
doi = {10.2147/opth.s652471},
url = {https://europepmc.org/article/MED/42903718},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Hypertension, Deep Retinal Perfusion, and Concurrent Visual Acuity in Retinal Vein Occlusion: A Cross-Sectional OCTA Study.
AU - Jinlian Zhan
AU - Yanting Lai
AU - Haichun Li
AU - Lin Lu
AU - Xiujuan Zhao
PY - 2026
DA - 2026/10/16
JO - Clinical ophthalmology (Auckland, N.Z.)
DO - 10.2147/opth.s652471
UR - https://europepmc.org/article/MED/42903718
AB - Background To investigate the cross-sectional association between hypertension and OCTA-derived retinal microvascular characteristics and to assess whether deep capillary plexus perfusion area (DCP-PA) provides additional explanatory information for concurrent visual acuity in retinal vein occlusion (RVO).Methods This retrospective secondary cross-sectional analysis included 88 RVO-affected eyes from 88 patients. Best-corrected visual acuity (BCVA) and swept-source OCTA were assessed at the same visit. Multivariable linear regression evaluated associations between hypertension and six OCTA outcomes after adjustment for age, sex, RVO subtype, and hyperlipidemia, with Benjamini-Hochberg false-discovery-rate (FDR) correction. The association between DCP-PA and concurrent logMAR BCVA was assessed using a clinical-structural model including age, sex, RVO subtype, hypertension, hyperlipidemia, and total retinal thickness (TRT), followed by an extended model incorporating DCP-PA.Results Hypertension was associated with lower DCP-PA (β=-1.71; 95% CI, -2.85 to -0.57; FDR-adjusted P=0.011) and lower DCP vessel length density (β=-3.29; 95% CI, -5.48 to -1.09; FDR-adjusted P=0.011). Lower DCP-PA remained independently associated with worse concurrent visual acuity after adjustment for clinical factors and TRT (β=-0.12 per mm²; 95% CI, -0.16 to -0.08; P<0.001). Hyperlipidemia was also associated with worse visual acuity (β=0.34; 95% CI, 0.18 to 0.49; P<0.001). Adding DCP-PA increased adjusted R ² from 0.40 to 0.59 and reduced AIC from 94.60 to 61.99 (partial F=38.54; P<0.001). No significant interaction was observed between DCP-PA and RVO subtype (P=0.353).Conclusions Hypertension was associated with reduced deep retinal perfusion in RVO. Lower DCP-PA was independently associated with worse concurrent visual acuity and provided additional explanatory information beyond clinical factors and retinal thickness. These cross-sectional findings do not establish causality or prospective prognostic value.
SN - 1177-5467
SN - 1177-5483
ER -