Development of a 4D Cerebral Microvascular Imaging Platform for Mouse Stroke Model

Abstract

In ischemic stroke, changes in cerebral hemodynamics during both the ischemic and reperfusion phases strongly influence stroke outcomes. However, these hemodynamic changes remain incompletely understood. To address this challenge, we devised an imaging platform that enables time-resolved ultrasound microvascular imaging during the experimental induction of ischemia and reperfusion in a mouse model. The platform leverages our previous ultrasound imaging framework combined with continuous mechanical scanning, which acquires whole-brain blood-flow signals within 5 s. The experiments demonstrated that the proposed platform can visualize both local and whole-brain hemodynamic responses to the induction of ischemia and reperfusion, suggesting its potential for rapid and continuous whole-brain hemodynamic assessment in small-animal models.

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BibTeX RIS

BibTeX

@misc{kaneko2026development,
  title = {{Development of a 4D Cerebral Microvascular Imaging Platform for Mouse Stroke Model}},
  author = {Yoshihisa Kaneko and Moe Kumai and Hiroyuki Igarashi and Daisuke Ando and Kuniyasu Niizuma and Hidenori Endo and Yoshifumi Saijo and Takuro Ishii},
  howpublished = {arXiv},
  year = {2026},
  month = sep,
  doi = {10.48550/arxiv.2609.16666},
  eprint = {2609.16666},
  archivePrefix = {arXiv},
  url = {https://arxiv.org/abs/2609.16666},
}

RIS

TY  - UNPB
TI  - Development of a 4D Cerebral Microvascular Imaging Platform for Mouse Stroke Model
AU  - Yoshihisa Kaneko
AU  - Moe Kumai
AU  - Hiroyuki Igarashi
AU  - Daisuke Ando
AU  - Kuniyasu Niizuma
AU  - Hidenori Endo
AU  - Yoshifumi Saijo
AU  - Takuro Ishii
PY  - 2026
DA  - 2026/09/15
PB  - arXiv
DO  - 10.48550/arxiv.2609.16666
UR  - https://arxiv.org/abs/2609.16666
AB  - In ischemic stroke, changes in cerebral hemodynamics during both the ischemic and reperfusion phases strongly influence stroke outcomes. However, these hemodynamic changes remain incompletely understood. To address this challenge, we devised an imaging platform that enables time-resolved ultrasound microvascular imaging during the experimental induction of ischemia and reperfusion in a mouse model. The platform leverages our previous ultrasound imaging framework combined with continuous mechanical scanning, which acquires whole-brain blood-flow signals within 5 s. The experiments demonstrated that the proposed platform can visualize both local and whole-brain hemodynamic responses to the induction of ischemia and reperfusion, suggesting its potential for rapid and continuous whole-brain hemodynamic assessment in small-animal models.
ER  -

Abstract

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