Shared Pathways between Psoriasis and Atopic Dermatitis.
- 1Dermatology Unit, Istituto Dermopatico dell'Immacolata IDI-IRCCS, Rome, Italy.
- 2Dermatology Unit, Department of Medical and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Abstract
Introduction
Psoriasis and atopic dermatitis are leading examples of chronic inflammatory dermatoses with distinct clinical manifestations, pathogenesis, and demographic patterns. However, recent research has revealed overlapping immunological pathways that could serve as promising therapeutic targets.Objectives
To synthesize the principal immunological, epidermal barrier, and microbiome pathways shared by psoriasis and atopic dermatitis and to discuss their potential translational and therapeutic implications.Methods
We conducted a narrative review of the literature on PubMed from January 2000 to June 2024, using keywords such as "psoriasis," "atopic dermatitis," "cytokine pathways," "T cells," and "environmental triggers." Studies were selected based on their relevance to shared mechanisms between these diseases, focusing on cytokine profiles, immune cell activity, and skin barrier dysfunction.Results
Our review identified significant overlaps in cytokine-mediated pathways, particularly the IL-17/IL-22 axis, which mediates keratinocyte hyperproliferation and inflammation in both diseases. T cell dysregulation, including Th17 and Th22 activity, plays a pivotal role in maintaining chronic inflammation. Both conditions also exhibit impaired skin barrier function, linked to filaggrin loss-of-function mutations in atopic dermatitis and abnormal keratinocyte differentiation in psoriasis.Conclusion
These findings suggest that targeting shared mechanisms, such as the Th17 and Th22 pathways, along with barrier repair strategies may enable dual therapeutic benefits. This review underscores the potential for integrative treatment approaches and personalized medicine in managing chronic inflammatory skin disorders.
Related
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- AD-REAL: A Prospective, Multinational, Observational Cohort Study of Clinical Effectiveness and Treatment Discontinuation of Oral Systemics for Moderate-to-Severe Atopic Dermatitis
- Real-Life Performance of the Dermatology Long-Term Life Impact Measure (DLLIM) in Atopic Dermatitis: An International Study of 15,450 Patients
- A bioinformatic single-cell and structure-informed framework identifies a baicalin–CA2–keratinocyte state axis in atopic dermatitis
BibTeX
@article{trovato2026shared,
title = {{Shared Pathways between Psoriasis and Atopic Dermatitis.}},
author = {Federica Trovato and Camilla Chello and Simone Amato and Antonio Di Guardo and Emanuele Amore and Luigi Bennardo and Antonio Giovanni Richetta and Teresa Grieco and Steven Paul Nisticò and Giovanni Pellacani and Annunziata Dattola},
journal = {Dermatology practical \& conceptual},
year = {2026},
month = jul,
doi = {10.5826/dpc.1603a6662},
url = {https://europepmc.org/article/MED/42858415},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Shared Pathways between Psoriasis and Atopic Dermatitis.
AU - Federica Trovato
AU - Camilla Chello
AU - Simone Amato
AU - Antonio Di Guardo
AU - Emanuele Amore
AU - Luigi Bennardo
AU - Antonio Giovanni Richetta
AU - Teresa Grieco
AU - Steven Paul Nisticò
AU - Giovanni Pellacani
AU - Annunziata Dattola
PY - 2026
DA - 2026/07/31
JO - Dermatology practical & conceptual
DO - 10.5826/dpc.1603a6662
UR - https://europepmc.org/article/MED/42858415
AB - Introduction Psoriasis and atopic dermatitis are leading examples of chronic inflammatory dermatoses with distinct clinical manifestations, pathogenesis, and demographic patterns. However, recent research has revealed overlapping immunological pathways that could serve as promising therapeutic targets.Objectives To synthesize the principal immunological, epidermal barrier, and microbiome pathways shared by psoriasis and atopic dermatitis and to discuss their potential translational and therapeutic implications.Methods We conducted a narrative review of the literature on PubMed from January 2000 to June 2024, using keywords such as "psoriasis," "atopic dermatitis," "cytokine pathways," "T cells," and "environmental triggers." Studies were selected based on their relevance to shared mechanisms between these diseases, focusing on cytokine profiles, immune cell activity, and skin barrier dysfunction.Results Our review identified significant overlaps in cytokine-mediated pathways, particularly the IL-17/IL-22 axis, which mediates keratinocyte hyperproliferation and inflammation in both diseases. T cell dysregulation, including Th17 and Th22 activity, plays a pivotal role in maintaining chronic inflammation. Both conditions also exhibit impaired skin barrier function, linked to filaggrin loss-of-function mutations in atopic dermatitis and abnormal keratinocyte differentiation in psoriasis.Conclusion These findings suggest that targeting shared mechanisms, such as the Th17 and Th22 pathways, along with barrier repair strategies may enable dual therapeutic benefits. This review underscores the potential for integrative treatment approaches and personalized medicine in managing chronic inflammatory skin disorders.
SN - 2160-9381
ER -