Skip to content
DraconiticResearch
Search Sources API
186,123 studies31 sourcesUpdated 19 min ago
Peer-reviewedCC BYJournal of the American Chemical Society

Direct Decarboxylative Borylation.

  • Paula Visiedo-Jiménez1
  • Quentin Ordan1
  • Sarah-Jayne Burlingham1
  • Francisco Juliá-Hernández1
  1. 1Facultad de Química, Centro Multidisciplinar Pleiades-Vitalis, Universidad de Murcia, 30100Murcia, Spain.
Read full textPDFDOICite

Abstract

Decarboxylative borylation provides a powerful route for converting abundant aliphatic carboxylic acids to synthetically versatile alkyl boronates. However, existing radical approaches require substrate preactivation, typically as redox-active esters, which prevents their application in the decarboxylative borylation of free carboxylic acids. Herein, we report an iron ligand-to-metal charge-transfer (LMCT) photocatalytic strategy that enables the direct decarboxylative borylation of nonactivated carboxylic acids. By harnessing the photoinduced inner-sphere electron-transfer reactivity of iron carboxylate complexes, this strategy provides direct access to alkyl boronates from native carboxylic acids, including those embedded in structurally complex and industrially relevant molecules. The method exhibits reactivity orthogonal to established redox-active ester borylation strategies and provides a scalable route to valuable organoboron reagents from chemical feedstocks.

Related

  1. Hypoboric Acid Catecholate (HAC) Catalysis for Stereoselective Decarboxylative Borylation of Redox-Active Esters
    S. V. Kohlhepp, M. Costantini, B. Meana-Baamonde +1
    ChemRxivPreprintCC BY-NC-NDFull textOrganic chemistryChemRxiv
  2. Sustainable photocatalytic borylation: updated review
    Kankanalla Naveen Kumar, Kamal Lochan Misra, Sharada Prasanna Swain
    ChemRxivPreprintLicence not statedGeneral chemistryChemRxiv
  3. Zinc Redox Catalysis in the Photochemical Borylation of Fluorocarbons
    Wenbang Yang, Aaranjah Vickneswaran, Alick Birmingham-Conner +1
    ChemRxivPreprintLicence not statedGeneral chemistryChemRxiv
  4. Decarboxylative radical C–C coupling of ⍺-(oxy/thio)acetic acids with electron-poor alkenes
    Taylor Semeniuk, Jean-Denys Hamel
    ChemRxivPreprintLicence not statedGeneral chemistryChemRxiv
  5. Ten-Step Total Synthesis of the Octadride (+)-Zopfiellin via Electrochemical Decarboxylative Cross-Coupling
    Adrien Merviel, Michael Seidl, Thomas Magauer
    ChemRxivPreprintCC BYFull textOrganic chemistryChemRxiv

Cite

BibTeXRIS
BibTeX
@article{visiedojimenez2026direct,
  title = {{Direct Decarboxylative Borylation.}},
  author = {Paula Visiedo-Jiménez and Quentin Ordan and Sarah-Jayne Burlingham and Francisco Juliá-Hernández},
  journal = {Journal of the American Chemical Society},
  year = {2026},
  month = sep,
  doi = {10.1021/jacs.6c13635},
  url = {https://europepmc.org/article/MED/42937868},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Direct Decarboxylative Borylation.
AU  - Paula Visiedo-Jiménez
AU  - Quentin Ordan
AU  - Sarah-Jayne Burlingham
AU  - Francisco Juliá-Hernández
PY  - 2026
DA  - 2026/09/01
JO  - Journal of the American Chemical Society
DO  - 10.1021/jacs.6c13635
UR  - https://europepmc.org/article/MED/42937868
AB  - Decarboxylative borylation provides a powerful route for converting abundant aliphatic carboxylic acids to synthetically versatile alkyl boronates. However, existing radical approaches require substrate preactivation, typically as redox-active esters, which prevents their application in the decarboxylative borylation of free carboxylic acids. Herein, we report an iron ligand-to-metal charge-transfer (LMCT) photocatalytic strategy that enables the direct decarboxylative borylation of nonactivated carboxylic acids. By harnessing the photoinduced inner-sphere electron-transfer reactivity of iron carboxylate complexes, this strategy provides direct access to alkyl boronates from native carboxylic acids, including those embedded in structurally complex and industrially relevant molecules. The method exhibits reactivity orthogonal to established redox-active ester borylation strategies and provides a scalable route to valuable organoboron reagents from chemical feedstocks.
SN  - 0002-7863
SN  - 1520-5126
ER  -