Alzheimers disease blood-based biomarkers in the Boston Latino Aging Study (BLAST): Associations with cognition and depressive symptoms
- 1Boston University
Abstract
BackgroundBlood-based biomarkers (BBMs) may facilitate early detection of Alzheimers disease (AD), yet data in Latino populations remain limited. We examined associations of plasma biomarkers with cognition and depressive symptoms in Spanish-speaking Latino older adults enrolled in the Boston Latino Aging Study (BLAST).
MethodsBaseline data from 122 adults aged [≥]55 years without dementia were analyzed. Plasma A{beta}42/40, brain-derived phosphorylated tau (p-tau) 217, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) were measured using NULISA. Cognition was assessed with the Latin American Spanish version of the Preclinical Alzheimers Cognitive Composite (LAS-PACC5) and depressive symptoms with the Geriatric Depression Scale (GDS). Regression models were adjusted for age, sex, and education.
ResultsCognitively impaired participants had higher p-tau217 and GFAP than cognitively normal participants. Higher p-tau217 and GFAP were associated with poorer LAS-PACC5 performance, while higher NfL was associated with greater depressive symptoms. A{beta}42/40 showed no significant associations.
ConclusionsDistinct biomarker associations with cognitive and emotional functioning support further longitudinal evaluation of BBMs for risk characterization in Latino older adults and potential disease monitoring applications.
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BibTeX
@misc{tristaopereira2026alzheimers,
title = {{Alzheimers disease blood-based biomarkers in the Boston Latino Aging Study (BLAST): Associations with cognition and depressive symptoms}},
author = {C. Tristao-Pereira and G. Silva and K. Lopez and V. Ku and A. Gonzalez and J. E. Martinez and A. Giudicessi and M. Rowe and S. M. Garcia and M. Gonzalez Catalan and D. Saldana and J. R. Gatchel and L. Ramirez Gomez and Y. T. Quiroz},
howpublished = {medRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.13.26365304},
url = {https://www.medrxiv.org/content/10.64898/2026.10.13.26365304v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Alzheimers disease blood-based biomarkers in the Boston Latino Aging Study (BLAST): Associations with cognition and depressive symptoms
AU - C. Tristao-Pereira
AU - G. Silva
AU - K. Lopez
AU - V. Ku
AU - A. Gonzalez
AU - J. E. Martinez
AU - A. Giudicessi
AU - M. Rowe
AU - S. M. Garcia
AU - M. Gonzalez Catalan
AU - D. Saldana
AU - J. R. Gatchel
AU - L. Ramirez Gomez
AU - Y. T. Quiroz
PY - 2026
DA - 2026/10/13
PB - medRxiv
DO - 10.64898/2026.10.13.26365304
UR - https://www.medrxiv.org/content/10.64898/2026.10.13.26365304v1
AB - BackgroundBlood-based biomarkers (BBMs) may facilitate early detection of Alzheimers disease (AD), yet data in Latino populations remain limited. We examined associations of plasma biomarkers with cognition and depressive symptoms in Spanish-speaking Latino older adults enrolled in the Boston Latino Aging Study (BLAST). MethodsBaseline data from 122 adults aged [≥]55 years without dementia were analyzed. Plasma A{beta}42/40, brain-derived phosphorylated tau (p-tau) 217, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) were measured using NULISA. Cognition was assessed with the Latin American Spanish version of the Preclinical Alzheimers Cognitive Composite (LAS-PACC5) and depressive symptoms with the Geriatric Depression Scale (GDS). Regression models were adjusted for age, sex, and education. ResultsCognitively impaired participants had higher p-tau217 and GFAP than cognitively normal participants. Higher p-tau217 and GFAP were associated with poorer LAS-PACC5 performance, while higher NfL was associated with greater depressive symptoms. A{beta}42/40 showed no significant associations. ConclusionsDistinct biomarker associations with cognitive and emotional functioning support further longitudinal evaluation of BBMs for risk characterization in Latino older adults and potential disease monitoring applications.
ER -