Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 24 min ago
Peer-reviewedCC BY 4.0Nutrients

Lipid Indicators and Low Bone Mass Among Taiwanese Adults: A Cross-Sectional Association Study

  • Hung-Shuo Ko1,2
  • Chiao-Wei Chang3
  • Chyi-Huey Bai4,5
5 affiliations
  1. 1Department of General Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333423, Taiwan
  2. 2School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan
  3. 3School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan
  4. 4Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan
  5. 5School of Public Health, College of Public Health, Taipei Medical University, Taipei 110301, Taiwan
Read full textPDFDOICite

Abstract

Background & Aims: This study investigated the associations of lipid indicators, particularly the total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C), with low bone mass in adults. Methods: This cross-sectional study included 6389 participants aged ≥19 years from the Nutrition and Health Survey in Taiwan (2013–2020). Two study-defined low-bone-mass phenotypes were evaluated as research phenotypes rather than densitometric diagnoses: central-site low bone mass, defined as a T-score < −1.0 at either the lumbar spine (L1–L4) or the lower of the bilateral femoral neck T-scores, and total-body low bone mass, defined as a total-body T-score < −1.0. Multivariable logistic regression models and restricted cubic spline analysis were performed to examine associations of lipid indicators with low bone mass. Subgroup analyses by sex, age, and age-defined menopausal status were exploratory. Results: Among 6389 participants, 1069 had total-body low bone mass. Total-body low bone mass showed more evident associations with lipid-related markers than central-site low bone mass. Each 10 mg/dL increase in HDL-C was associated with higher odds of total-body low bone mass (adjusted odds ratio [OR] = 1.080, 95% confidence interval [CI]: 1.018–1.147, p = 0.011). Although the linear association between TC/HDL-C and low bone mass was not statistically significant, spline analysis revealed a significant nonlinear association with total-body low bone mass, with a turning point at 4.39 (p for nonlinearity = 0.016). Exploratory analyses suggested effect modification by age and age-based grouping. Conclusions: Total-body low bone mass showed more evident associations with lipid indicators than central-site low bone mass. HDL-C was linearly associated with low bone mass, whereas TC/HDL-C showed an exploratory nonlinear association, supporting its potential role as a readily available metabolic correlate of skeletal status.

Related

  1. Glucose and lipid metabolism indicators associate with metabolic syndrome risk prediction in adults with hypertension
    Yingxin Guo, Lixuan Chen, Xinyi Ouyang +16
    Communications MedicinePeer-reviewedCC BY-NC-ND 4.0Full textEndocrinology & metabolismCrossref
  2. Association between the use of smoking products and exposure to environmental contaminants derived from their use with early indicators of pulmonary risk in young adults aged 18–24 years: protocol for a systematic review
    Juan Camilo Murillo Coca, Jhonatan Oliver Ricardo Parra Ortegón, Laura Vanessa Rodríguez Mendoza +1
    BMJ OpenPeer-reviewedLicence not statedGeneral medicineCrossref
  3. Association of Traditional and Emerging Anthropometric Indices With Subclinical Carotid Atherosclerosis in Young Healthy Adults: Insights From the Tehran Lipid and Glucose Study
    Behnaz Abiri, Amirhossein Ramezani Ahmadi, Farhad Hosseinpanah +6
    Endocrinology, diabetes & metabolismPeer-reviewedCC BYFull textEndocrinology & metabolismEurope PMC
  4. Breakfast Dietary Patterns and Their Associations with Metabolic Indicators and NAFLD Severity: A Cross-Sectional Study Among Iranian Adults.
    Mehrdad Kianmehr, Maryam Rafraf, Alireza Hosseini +2
    Health promotion perspectivesPeer-reviewedCC BYFull textEpidemiology & public healthEurope PMCPMC
  5. Lifestyle risk indicators and health promotion priorities among adults with heart failure in Hargeisa Somaliland: a hospital based cross sectional study
    Abdirahman Ali Osman, Vitalis Okath, Abdikarim Mousse Duale +1
    Frontiers in Public HealthPeer-reviewedCC BY 4.0Epidemiology & public healthCrossref

Cite

BibTeXRIS
BibTeX
@article{ko2026lipid,
  title = {{Lipid Indicators and Low Bone Mass Among Taiwanese Adults: A Cross-Sectional Association Study}},
  author = {Hung-Shuo Ko and Chiao-Wei Chang and Chyi-Huey Bai},
  journal = {Nutrients},
  year = {2026},
  month = oct,
  doi = {10.3390/nu18203349},
  url = {https://www.mdpi.com/2072-6643/18/20/3349},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Lipid Indicators and Low Bone Mass Among Taiwanese Adults: A Cross-Sectional Association Study
AU  - Hung-Shuo Ko
AU  - Chiao-Wei Chang
AU  - Chyi-Huey Bai
PY  - 2026
DA  - 2026/10/13
JO  - Nutrients
DO  - 10.3390/nu18203349
UR  - https://www.mdpi.com/2072-6643/18/20/3349
AB  - Background & Aims: This study investigated the associations of lipid indicators, particularly the total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C), with low bone mass in adults. Methods: This cross-sectional study included 6389 participants aged ≥19 years from the Nutrition and Health Survey in Taiwan (2013–2020). Two study-defined low-bone-mass phenotypes were evaluated as research phenotypes rather than densitometric diagnoses: central-site low bone mass, defined as a T-score < −1.0 at either the lumbar spine (L1–L4) or the lower of the bilateral femoral neck T-scores, and total-body low bone mass, defined as a total-body T-score < −1.0. Multivariable logistic regression models and restricted cubic spline analysis were performed to examine associations of lipid indicators with low bone mass. Subgroup analyses by sex, age, and age-defined menopausal status were exploratory. Results: Among 6389 participants, 1069 had total-body low bone mass. Total-body low bone mass showed more evident associations with lipid-related markers than central-site low bone mass. Each 10 mg/dL increase in HDL-C was associated with higher odds of total-body low bone mass (adjusted odds ratio [OR] = 1.080, 95% confidence interval [CI]: 1.018–1.147, p = 0.011). Although the linear association between TC/HDL-C and low bone mass was not statistically significant, spline analysis revealed a significant nonlinear association with total-body low bone mass, with a turning point at 4.39 (p for nonlinearity = 0.016). Exploratory analyses suggested effect modification by age and age-based grouping. Conclusions: Total-body low bone mass showed more evident associations with lipid indicators than central-site low bone mass. HDL-C was linearly associated with low bone mass, whereas TC/HDL-C showed an exploratory nonlinear association, supporting its potential role as a readily available metabolic correlate of skeletal status.
SN  - 2072-6643
ER  -