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Peer-reviewedCC BY 4.0Journal of Clinical Medicine

Cognitive Impairment and Functional Independence in Hospitalized Patients with Atrial Fibrillation: A Cross-Sectional Study

  • Dania Hasanein1,2
  • Oana Elena Țunea1,2,3
  • Samuel Ardelean1,4,5,6
  • Daniel Florin Lighezan1,2,3
6 affiliations
  1. 1Doctoral School of Medicine, “Victor Babeș” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
  2. 2Centre for Advanced Research in Cardiovascular Pathology and Hemostaseology, “Victor Babeș” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
  3. 3Department of Internal Medicine I, 1st Clinic of Medical Semiology, “Victor Babeș” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
  4. 4Department of Cardiology, Institute of Cardiovascular Diseases, Str. Gheorghe Adam No. 13A, 300310 Timișoara, Romania
  5. 5Department V, Internal Medicine 1, “Victor Babeș” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
  6. 6Multidisciplinary Heart Research Center, Faculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
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Abstract

Background/Objectives: Atrial fibrillation (AF) is associated with cognitive decline even without clinically apparent stroke, but the relative contributions of demographic, vascular, inflammatory and therapeutic factors remain unclear. We aimed to explore clinical determinants of cognitive and functional performance in hospitalized patients with AF. Methods: In this exploratory cross-sectional study, 62 consecutive patients with documented AF admitted to an internal medicine department underwent assessment with the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE) and Activities of Daily Living (ADL) scale. Associations were examined with multivariable linear regression, with false-discovery-rate correction and sensitivity analyses. Results: Mean age was 75.3 ± 8.1 years; 17 patients (27.4%) had a previous ischemic stroke. Fifty-nine patients (95.2%) scored below the MoCA threshold of 26 and 35 (56.5%) below the MMSE threshold of 24. Patients with previous stroke scored lower on all three instruments (MoCA mean difference 4.13, 95% CI 0.75–7.51; MMSE 4.84, 1.67–8.01; ADL 1.69, 0.25–3.12). After correction for multiple testing, age remained associated with all three outcomes and previous stroke with MMSE score; no association was detected for sex, education, diabetes, C-reactive protein, LDL-cholesterol or anticoagulant type. Higher CHA2DS2-VAScscores were associated with poorer performance, though not independently of their own components. Conclusions: In this exploratory study, cognitive impairment was common among hospitalized patients with AF and was associated with age and previous stroke. These hypothesis-generating findings require confirmation in larger prospective studies.

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Cite

BibTeXRIS
BibTeX
@article{hasanein2026cognitive,
  title = {{Cognitive Impairment and Functional Independence in Hospitalized Patients with Atrial Fibrillation: A Cross-Sectional Study}},
  author = {Dania Hasanein and Oana Elena Țunea and Samuel Ardelean and Daniel Florin Lighezan},
  journal = {Journal of Clinical Medicine},
  year = {2026},
  month = oct,
  doi = {10.3390/jcm15208075},
  url = {https://www.mdpi.com/2077-0383/15/20/8075},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Cognitive Impairment and Functional Independence in Hospitalized Patients with Atrial Fibrillation: A Cross-Sectional Study
AU  - Dania Hasanein
AU  - Oana Elena Țunea
AU  - Samuel Ardelean
AU  - Daniel Florin Lighezan
PY  - 2026
DA  - 2026/10/01
JO  - Journal of Clinical Medicine
DO  - 10.3390/jcm15208075
UR  - https://www.mdpi.com/2077-0383/15/20/8075
AB  - Background/Objectives: Atrial fibrillation (AF) is associated with cognitive decline even without clinically apparent stroke, but the relative contributions of demographic, vascular, inflammatory and therapeutic factors remain unclear. We aimed to explore clinical determinants of cognitive and functional performance in hospitalized patients with AF. Methods: In this exploratory cross-sectional study, 62 consecutive patients with documented AF admitted to an internal medicine department underwent assessment with the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE) and Activities of Daily Living (ADL) scale. Associations were examined with multivariable linear regression, with false-discovery-rate correction and sensitivity analyses. Results: Mean age was 75.3 ± 8.1 years; 17 patients (27.4%) had a previous ischemic stroke. Fifty-nine patients (95.2%) scored below the MoCA threshold of 26 and 35 (56.5%) below the MMSE threshold of 24. Patients with previous stroke scored lower on all three instruments (MoCA mean difference 4.13, 95% CI 0.75–7.51; MMSE 4.84, 1.67–8.01; ADL 1.69, 0.25–3.12). After correction for multiple testing, age remained associated with all three outcomes and previous stroke with MMSE score; no association was detected for sex, education, diabetes, C-reactive protein, LDL-cholesterol or anticoagulant type. Higher CHA2DS2-VAScscores were associated with poorer performance, though not independently of their own components. Conclusions: In this exploratory study, cognitive impairment was common among hospitalized patients with AF and was associated with age and previous stroke. These hypothesis-generating findings require confirmation in larger prospective studies.
SN  - 2077-0383
ER  -