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Peer-reviewedCC BYBioengineering (Basel, Switzerland)

RCNet: A Hybrid Network Adapted for OCTA Retinal Capillary Segmentation.

  1. 1School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou 325000, China.
  2. 2School of Data Science and Artificial Intelligence, Wenzhou University of Technology, Wenzhou 325000, China.

Abstract

Optical Coherence Tomography Angiography (OCTA) provides clear visualization of ocular microvascular details, serving as a critical tool for assessing retinal and choroidal vascular systems. However, the complex capillary structure and low capillary-to-background contrast in high-resolution OCTA images pose significant challenges for segmentation. To address the low segmentation accuracy of traditional methods, this paper proposes RCNet, a hybrid CNN-Transformer network. RCNet adopts an encoder-decoder architecture based on Bi-Level Routing Attention (BRA), where bi-level routing attention focuses on densely vascularized regions, optimizing global capillary feature extraction. A Convolutional Bottleneck Module (CBM) splits bottleneck features into two channel groups using a fixed ratio α. A high-capacity branch enhances local details, while a lightweight branch preserves complementary information. The branches are then fused. Additionally, a Dense Skip Connection Module (DSCM) enhances feature information flow in low-contrast regions, compensating for spatial information loss. By integrating CNN's local feature extraction with Transformer's global dependency modeling, RCNet achieves accurate segmentation of OCTA capillary images. Experiments on the OCTA-500 and ROSE datasets demonstrate that RCNet achieved a higher point estimate under the current protocol, facilitating and assisting in the clinical assessment of ocular diseases.

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BibTeX
@article{wang2026rcnet,
  title = {{RCNet: A Hybrid Network Adapted for OCTA Retinal Capillary Segmentation.}},
  author = {Xudong Wang and Qinghong Gao and Ran Yang and Xuelian Yang and Rui Yao and Shu'an Liu and Maosong Jiang and Caiye Fan and Zuoping Tan and Yuanyuan Wang},
  journal = {Bioengineering (Basel, Switzerland)},
  year = {2026},
  month = sep,
  doi = {10.3390/bioengineering13101147},
  url = {https://europepmc.org/article/MED/42939002},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - RCNet: A Hybrid Network Adapted for OCTA Retinal Capillary Segmentation.
AU  - Xudong Wang
AU  - Qinghong Gao
AU  - Ran Yang
AU  - Xuelian Yang
AU  - Rui Yao
AU  - Shu'an Liu
AU  - Maosong Jiang
AU  - Caiye Fan
AU  - Zuoping Tan
AU  - Yuanyuan Wang
PY  - 2026
DA  - 2026/09/30
JO  - Bioengineering (Basel, Switzerland)
DO  - 10.3390/bioengineering13101147
UR  - https://europepmc.org/article/MED/42939002
AB  - Optical Coherence Tomography Angiography (OCTA) provides clear visualization of ocular microvascular details, serving as a critical tool for assessing retinal and choroidal vascular systems. However, the complex capillary structure and low capillary-to-background contrast in high-resolution OCTA images pose significant challenges for segmentation. To address the low segmentation accuracy of traditional methods, this paper proposes RCNet, a hybrid CNN-Transformer network. RCNet adopts an encoder-decoder architecture based on Bi-Level Routing Attention (BRA), where bi-level routing attention focuses on densely vascularized regions, optimizing global capillary feature extraction. A Convolutional Bottleneck Module (CBM) splits bottleneck features into two channel groups using a fixed ratio α. A high-capacity branch enhances local details, while a lightweight branch preserves complementary information. The branches are then fused. Additionally, a Dense Skip Connection Module (DSCM) enhances feature information flow in low-contrast regions, compensating for spatial information loss. By integrating CNN's local feature extraction with Transformer's global dependency modeling, RCNet achieves accurate segmentation of OCTA capillary images. Experiments on the OCTA-500 and ROSE datasets demonstrate that RCNet achieved a higher point estimate under the current protocol, facilitating and assisting in the clinical assessment of ocular diseases.
SN  - 2306-5354
ER  -