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Peer-reviewedCC BY 4.0ACS Omega

Drug-Initiated Synthesis and Processing of Mupirocin–PLGA Conjugates for Biodegradable Antibacterial Scaffolds

  • Tomasz Urbaniak1
  • Zuzanna Podgórniak1
  • Adam Junka1,2
  • Jolanta Harasiuk3
  • Witold Musiał1
  1. 1Wroclaw Medical University , , Borowska 211 , ,
  2. 2Zhejiang Sci-Tech University , , 928 Second Avenue, Xiasha Higher Education Zone , , ,
  3. 3Wroclaw Medical University , , Borowska 211a , ,
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Abstract

Mupirocin–poly(lactic-co-glycolic acid) (Mup-PLGA) conjugates were developed via drug-initiated ring-opening polymerization to create biodegradable scaffolds with local antibacterial activity. Conjugate composition and molecular weight were controlled to tune degradation behavior, and materials were processed into porous solvent-cast scaffolds and electrospun mats. Degradation studies showed that molecular weight, copolymer ratio, and plasticizer content governed structural evolution, while the processing method had a limited effect. No measurable release of free mupirocin was detected during degradation. Despite this, antibacterial activity was observed under direct-contact conditions and correlated with conjugate composition, reflecting mupirocin content along polymer chains. Electrospun scaffolds exhibited limited diffusible activity, attributed to higher surface area. Overall, the materials did not behave as classical release systems but showed surface-mediated antibacterial effects instead. These findings position Mup-PLGA conjugates as a platform for wound dressings combining tunable degradation with local antimicrobial functionality, potentially reducing exposure to subinhibitory free antibiotic concentrations. Extract-based MTT testing showed mean cell viability above the 70% criterion for both electrospun mats and the nonplasticized SC7 scaffold, whereas TEC-containing solvent-cast scaffolds were cytotoxic.

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Cite

BibTeXRIS
BibTeX
@article{urbaniak2026druginitiated,
  title = {{Drug-Initiated Synthesis and Processing of Mupirocin–PLGA Conjugates for Biodegradable Antibacterial Scaffolds}},
  author = {Tomasz Urbaniak and Zuzanna Podgórniak and Adam Junka and Jolanta Harasiuk and Witold Musiał},
  journal = {ACS Omega},
  year = {2026},
  month = oct,
  doi = {10.1021/acsomega.6c06646},
  url = {https://pubs.acs.org/acsodf/article/11/41/63299/5444898/Drug-Initiated-Synthesis-and-Processing-of},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Drug-Initiated Synthesis and Processing of Mupirocin–PLGA Conjugates for Biodegradable Antibacterial Scaffolds
AU  - Tomasz Urbaniak
AU  - Zuzanna Podgórniak
AU  - Adam Junka
AU  - Jolanta Harasiuk
AU  - Witold Musiał
PY  - 2026
DA  - 2026/10/05
JO  - ACS Omega
DO  - 10.1021/acsomega.6c06646
UR  - https://pubs.acs.org/acsodf/article/11/41/63299/5444898/Drug-Initiated-Synthesis-and-Processing-of
AB  - Mupirocin–poly(lactic-co-glycolic acid) (Mup-PLGA) conjugates were developed via drug-initiated ring-opening polymerization to create biodegradable scaffolds with local antibacterial activity. Conjugate composition and molecular weight were controlled to tune degradation behavior, and materials were processed into porous solvent-cast scaffolds and electrospun mats. Degradation studies showed that molecular weight, copolymer ratio, and plasticizer content governed structural evolution, while the processing method had a limited effect. No measurable release of free mupirocin was detected during degradation. Despite this, antibacterial activity was observed under direct-contact conditions and correlated with conjugate composition, reflecting mupirocin content along polymer chains. Electrospun scaffolds exhibited limited diffusible activity, attributed to higher surface area. Overall, the materials did not behave as classical release systems but showed surface-mediated antibacterial effects instead. These findings position Mup-PLGA conjugates as a platform for wound dressings combining tunable degradation with local antimicrobial functionality, potentially reducing exposure to subinhibitory free antibiotic concentrations. Extract-based MTT testing showed mean cell viability above the 70% criterion for both electrospun mats and the nonplasticized SC7 scaffold, whereas TEC-containing solvent-cast scaffolds were cytotoxic.
SN  - 2470-1343
ER  -