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PreprintCC BYChemRxiv

Engineering Gold Nanoparticles for Transmembrane Anion Transport

  • Meenakshi Pahwa1
  • Debashis Mondal1
  • Julia Blandine Bassila2
  • Davide Bochicchio2,3
  • Giulia Rossi2,3
  • Michał J. Chmielewski1
  1. 1Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, Warszawa, Poland, 02-089
  2. 2Physics Department, University of Genoa, Via Dodecaneso 33, Genoa, Italy, 16146
  3. 3INFN sezione di Genova, Via Dodecaneso 33, Genoa, Italy, 16146
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Abstract

Synthetic transmembrane ion transporters are traditionally classified as either ion channels or carriers. Here we introduce a new nanoparticle-based transporter architecture in which spherical gold nanoparticles densely decorated with flexible urea- and thiourea-based ion-binding arms efficiently mediate transmembrane anion transport, providing the first proof of principle for nanoparticle-based transmembrane anion transport. Molecular dynamics simulations reveal a dynamic relay mechanism in which chloride ions migrate across the membrane by successive hopping between flexible ion-binding arms, while thermal rotational motion of the nanoparticle further facilitates translocation by repeatedly dragging these arms between the aqueous phase and the membrane interior. These findings introduce a new design principle for the construction of synthetic ion transporters based on densely functionalized multivalent nanoparticles.

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Cite

BibTeXRIS
BibTeX
@misc{pahwa2026engineering,
  title = {{Engineering Gold Nanoparticles for Transmembrane Anion Transport}},
  author = {Meenakshi Pahwa and Debashis Mondal and Julia Blandine Bassila and Davide Bochicchio and Giulia Rossi and Michał J. Chmielewski},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15009372/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009372/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Engineering Gold Nanoparticles for Transmembrane Anion Transport
AU  - Meenakshi Pahwa
AU  - Debashis Mondal
AU  - Julia Blandine Bassila
AU  - Davide Bochicchio
AU  - Giulia Rossi
AU  - Michał J. Chmielewski
PY  - 2026
DA  - 2026/09/23
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15009372/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009372/v1
AB  - Synthetic transmembrane ion transporters are traditionally classified as either ion channels or carriers. Here we introduce a new nanoparticle-based transporter architecture in which spherical gold nanoparticles densely decorated with flexible urea- and thiourea-based ion-binding arms efficiently mediate transmembrane anion transport, providing the first proof of principle for nanoparticle-based transmembrane anion transport. Molecular dynamics simulations reveal a dynamic relay mechanism in which chloride ions migrate across the membrane by successive hopping between flexible ion-binding arms, while thermal rotational motion of the nanoparticle further facilitates translocation by repeatedly dragging these arms between the aqueous phase and the membrane interior. These findings introduce a new design principle for the construction of synthetic ion transporters based on densely functionalized multivalent nanoparticles.
ER  -