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Peer-reviewedCC BY 4.0Frontiers in Immunology

Heat stroke–induced liver injury: mechanistic insights, immune dynamics, and emerging therapeutic targets

  • Ning Li1
  • Sujing Liu2
  • Xinyu Hu1
  • Xiaoqing Wu1
  • Mengna Song1
  • Fang Luan1
  • Youyong Tang1
  • Yong Wang1
  1. 1Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University
  2. 2Department of Oncology, Shandong Provincial Third Hospital, Shandong University
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Abstract

Heat stroke is a life-threatening heat-related emergency that often leads to multiple organ dysfunction syndrome (MODS), with liver injury among its most prominent manifestations. HS-associated acute liver injury (HS-ALI) is a major determinant of prognosis, yet its pathogenesis remains incompletely understood. Current evidence suggests that HS-ALI results from the interplay of direct thermal stress, systemic inflammation, oxidative imbalance, coagulation dysfunction, and regulated cell death. Emerging experimental studies have implicated pyroptosis, ferroptosis, necroptosis, and gut–liver immune crosstalk in HS-associated tissue injury; however, the strength of evidence varies considerably among these mechanisms, and direct validation in human HS-ALI remains limited. Accordingly, these pathways should be considered potential contributors to disease progression rather than uniformly established mechanisms.

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Cite

BibTeXRIS
BibTeX
@article{li2026heat,
  title = {{Heat stroke–induced liver injury: mechanistic insights, immune dynamics, and emerging therapeutic targets}},
  author = {Ning Li and Sujing Liu and Xinyu Hu and Xiaoqing Wu and Mengna Song and Fang Luan and Youyong Tang and Yong Wang},
  journal = {Frontiers in Immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.1864759},
  url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1864759/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Heat stroke–induced liver injury: mechanistic insights, immune dynamics, and emerging therapeutic targets
AU  - Ning Li
AU  - Sujing Liu
AU  - Xinyu Hu
AU  - Xiaoqing Wu
AU  - Mengna Song
AU  - Fang Luan
AU  - Youyong Tang
AU  - Yong Wang
PY  - 2026
DA  - 2026/10/30
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.1864759
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1864759/full
AB  - Heat stroke is a life-threatening heat-related emergency that often leads to multiple organ dysfunction syndrome (MODS), with liver injury among its most prominent manifestations. HS-associated acute liver injury (HS-ALI) is a major determinant of prognosis, yet its pathogenesis remains incompletely understood. Current evidence suggests that HS-ALI results from the interplay of direct thermal stress, systemic inflammation, oxidative imbalance, coagulation dysfunction, and regulated cell death. Emerging experimental studies have implicated pyroptosis, ferroptosis, necroptosis, and gut–liver immune crosstalk in HS-associated tissue injury; however, the strength of evidence varies considerably among these mechanisms, and direct validation in human HS-ALI remains limited. Accordingly, these pathways should be considered potential contributors to disease progression rather than uniformly established mechanisms.
SN  - 1664-3224
ER  -