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Peer-reviewedCC BYRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

Micronutrient supplementation during pregnancy: evidence, indications, and safety - Number 14 - 2026.

  • Lílian de Paiva Rodrigues Hsu1
  • Eliana Martorano Amaral2
  • Adriana Gomes Luz2
  • Eura Martins Lage3
  • Mônica Lopez Vazquéz1
  • Joeline Maria Cleto Cerqueira4
4 affiliations
  1. 1Santa Casa de São Paulo Faculdade de Ciências Médicas São PauloSP Brazil Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, Brazil.
  2. 2Universidade Estadual de Campinas Faculdade de Ciências Médicas CampinasSP Brazil Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.
  3. 3Universidade Federal de Minas Gerais Faculdade de Medicina Belo HorizonteMG Brazil Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  4. 4Universidade Estadual do Piauí TeresinaPI Brazil Universidade Estadual do Piauí, Teresina, PI, Brazil.
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Abstract

•Structured nutritional assessment during prenatal care is essential for rationalizing therapy and promoting equity in healthcare. •Decisions regarding micronutrient supplementation during pregnancy must distinguish between interventions offering population-level benefits (for populations with low micronutrient intake) and strategies based on individual risk. •Folic acid and iron remain the supplements most strongly supported by robust and consistent evidence. •Calcium supplementation reduces the risk of preeclampsia in populations with low dietary intake and is indicated for specific subgroups or populations with documented deficiency. •The indiscriminate prescription of multivitamins lacks consistent support in the literature and leads to unnecessary, excessive medicalization during prenatal care. •Evidence regarding universal supplementation with vitamin D, docosahexaeonic acid (DHA/omega-3), vitamin B12, and iodine is inconsistent. Such supplementation is indicated for specific subgroups or populations with documented deficiency. •Tailoring supplementation to the individual represents an advance in evidence-based practice without replacing interventions of proven population-level benefit.

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Cite

BibTeXRIS
BibTeX
@article{hsu2026micronutrient,
  title = {{Micronutrient supplementation during pregnancy: evidence, indications, and safety - Number 14 - 2026.}},
  author = {Lílian de Paiva Rodrigues Hsu and Eliana Martorano Amaral and Adriana Gomes Luz and Eura Martins Lage and Mônica Lopez Vazquéz and Joeline Maria Cleto Cerqueira},
  journal = {Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia},
  year = {2026},
  month = sep,
  doi = {10.61622/rbgo/2026fps14},
  url = {https://europepmc.org/article/MED/42921172},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Micronutrient supplementation during pregnancy: evidence, indications, and safety - Number 14 - 2026.
AU  - Lílian de Paiva Rodrigues Hsu
AU  - Eliana Martorano Amaral
AU  - Adriana Gomes Luz
AU  - Eura Martins Lage
AU  - Mônica Lopez Vazquéz
AU  - Joeline Maria Cleto Cerqueira
PY  - 2026
DA  - 2026/09/14
JO  - Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
DO  - 10.61622/rbgo/2026fps14
UR  - https://europepmc.org/article/MED/42921172
AB  - •Structured nutritional assessment during prenatal care is essential for rationalizing therapy and promoting equity in healthcare. •Decisions regarding micronutrient supplementation during pregnancy must distinguish between interventions offering population-level benefits (for populations with low micronutrient intake) and strategies based on individual risk. •Folic acid and iron remain the supplements most strongly supported by robust and consistent evidence. •Calcium supplementation reduces the risk of preeclampsia in populations with low dietary intake and is indicated for specific subgroups or populations with documented deficiency. •The indiscriminate prescription of multivitamins lacks consistent support in the literature and leads to unnecessary, excessive medicalization during prenatal care. •Evidence regarding universal supplementation with vitamin D, docosahexaeonic acid (DHA/omega-3), vitamin B12, and iodine is inconsistent. Such supplementation is indicated for specific subgroups or populations with documented deficiency. •Tailoring supplementation to the individual represents an advance in evidence-based practice without replacing interventions of proven population-level benefit.
SN  - 0100-7203
SN  - 1806-9339
ER  -