Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 52 min ago
Peer-reviewedCC BY-NC-NDACG case reports journal

Small-Bowel Obstruction due to AA Amyloidosis in Presumed Extrapulmonary Tuberculosis

  • Jacoba van Wees1
  • Terry Yan1
  • Robin Sia2
  • Diana Moir3
  • Irene Lu1
  • Diana Lewis1
  1. 1Department of Gastroenterology, Northern Health, Melbourne, Victoria, Australia
  2. 2Department of Infectious Disease, Northern Health, Melbourne, Victoria, Australia
  3. 3Department of Anatomical Pathology, Northern Health, Melbourne, Victoria, Australia
Read full textPDFDOICite

Abstract

AA amyloidosis is rare in resource-rich settings, but remains prevalent in regions with untreated infection, particularly tuberculosis. We describe a case in Australia of a 68-year-old Somali-born woman with recurrent small-bowel obstruction, weight loss, and retroperitoneal lymphadenopathy. While colonoscopy was macroscopically normal, small-bowel biopsies revealed Congo red-positive AA amyloidosis. Lymph-node biopsy showed histiocytes with granulomatous inflammation, and tuberculosis testing was negative. Given epidemiologic factors and chronic inflammation, culture-negative tuberculosis with AA amyloidosis sequelae was presumed. Empirical tuberculous treatment led to clinical improvement and resolution of PET-avid lymphadenopathy, highlighting an unusual case of infiltrative small-bowel disease.

Related

  1. Clinical and laboratory determinants of treatment response and rifampicin resistance among Xpert MTB/RIF-confirmed extrapulmonary tuberculosis patients: A prospective study from Central India
    Gautam Bhagwat, Mala Kanthali, Swati Chauhan +3
    PLOS OnePeer-reviewedCC BYFull textGeneral biochemistryCell biologyPLOSEurope PMCPMC
  2. A Progressive 99mTc-MDP Uptake in Transthyretin Cardiac Amyloidosis
    Satoshi Kurisu, Hitoshi Fujiwara, Kosuke Asano
    Internal MedicinePeer-reviewedCC BY-NC-NDFull textMolecular biology & gene regulationJ-STAGE
  3. The Progressive Cardiac Uptake of 99mTc-MDP as a Clue to Transthyretin Amyloidosis
    Kazufumi Nakamura
    Internal MedicinePeer-reviewedCC BY-NC-NDFull textMolecular biology & gene regulationJ-STAGE
  4. Effect of Transthyretin Stabilizer in Transthyretin Cardiac Amyloidosis
    Toru Kubo, Yuri Ochi, Yuichi Baba +1
    Internal MedicinePeer-reviewedCC BY-NC-NDFull textMolecular biology & gene regulationJ-STAGE
  5. Transthyretin Amyloidosis: From Mechanisms to Treatment
    Filippos Triposkiadis, Andrew Xanthopoulos, Georghios P. Georghiou +2
    BiomoleculesPeer-reviewedCC BYFull textGeneral biochemistryEurope PMC

Cite

BibTeXRIS
BibTeX
@article{wees2026smallbowel,
  title = {{Small-Bowel Obstruction due to AA Amyloidosis in Presumed Extrapulmonary Tuberculosis}},
  author = {Jacoba van Wees and Terry Yan and Robin Sia and Diana Moir and Irene Lu and Diana Lewis},
  journal = {ACG case reports journal},
  year = {2026},
  month = oct,
  doi = {10.14309/crj.0000000000002392},
  url = {https://europepmc.org/article/PMC/PMC13722498},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Small-Bowel Obstruction due to AA Amyloidosis in Presumed Extrapulmonary Tuberculosis
AU  - Jacoba van Wees
AU  - Terry Yan
AU  - Robin Sia
AU  - Diana Moir
AU  - Irene Lu
AU  - Diana Lewis
PY  - 2026
DA  - 2026/10/30
JO  - ACG case reports journal
DO  - 10.14309/crj.0000000000002392
UR  - https://europepmc.org/article/PMC/PMC13722498
AB  - AA amyloidosis is rare in resource-rich settings, but remains prevalent in regions with untreated infection, particularly tuberculosis. We describe a case in Australia of a 68-year-old Somali-born woman with recurrent small-bowel obstruction, weight loss, and retroperitoneal lymphadenopathy. While colonoscopy was macroscopically normal, small-bowel biopsies revealed Congo red-positive AA amyloidosis. Lymph-node biopsy showed histiocytes with granulomatous inflammation, and tuberculosis testing was negative. Given epidemiologic factors and chronic inflammation, culture-negative tuberculosis with AA amyloidosis sequelae was presumed. Empirical tuberculous treatment led to clinical improvement and resolution of PET-avid lymphadenopathy, highlighting an unusual case of infiltrative small-bowel disease.
SN  - 2326-3253
ER  -