The PASE Study: The Prevalence and Associations of Bendopnoea in Patients with Pneumothorax.
5 affiliations
- 1Exercise Medicine Research Institute, Edith Cowan University, Joondalup, Perth, WA 6027, Australia.
- 2Pleural Medicine Unit, Institute for Respiratory Health, Nedlands, Perth, WA 6009, Australia.
- 3Centre for Innovative Pleural Research, Sir Charles Gairdner Hospital, Nedlands, Perth, WA 6009, Australia.
- 4Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Perth, WA 6009, Australia.
- 5School of Medicine, University of Western Australia, Crawley, Perth, WA 6009, Australia.
Abstract
Background: We recently established that bendopnoea (breathlessness upon bending forward) is common with pleural effusion; however, it has never been reported or investigated in patients with pneumothorax. This exploratory study investigated the prevalence and clinical relevance of bendopnoea in pneumothorax. Methods: Patients with pneumothorax of any aetiology or size were eligible. The presence of bendopnoea and time-to-bendopnoea was measured by bending the patient forward for 60 s and was assessed at baseline and post lung re-expansion. Results: Fifty patients (median age 48 years; 78% male) with primary spontaneous (48%), secondary spontaneous (24%) or iatrogenic (28%) pneumothorax were included. Pneumothorax size ranged from 7 to 99% of the hemithorax on chest radiographs. Most patients (74%) received conservative management. On a questionnaire, 48% (24/50) patients reported they experienced bendopnoea which "impacted daily life". When bent forward, 32% (16/50) developed bendopnoea within 60 s. Patients with bendopnoea reported more breathlessness than those without bendopnoea on a 100 mm Visual Analogue Scale (VAS): median 46 [Q1-Q3 = 25-54] vs. 12 [3-32] mm, respectively, p = 0.0089; median difference -23 mm (95% CI -35 to -6). Those with bendopnoea showed a signal with worse chest pain on a 100 mm VAS for pain: median 28 [13-48] vs. 10 [2-42] mm, p = 0.0528; median difference -15 mm (95% CI -27 to 0). Shorter time-to-bendopnoea (i.e., worse bendopnoea) correlated with worse breathlessness (rs = -0.38, 95% CI -0.6 to -0.1; p = 0.0072) and more severe chest pain (rs = -0.29, 95% CI -0.5 to -0.007; p = 0.039). Conclusions: Bendopnoea can occur with pneumothorax, correlates with breathlessness and demonstrates a signal with worse chest pain.
Related
- Prevalence and Associations for Use of Complementary and Alternative Medicine (CAM) Among Paediatric Cancer Patients in Norway: A Cross-Sectional Survey
- Population-Level Associations of Diabetes Prevalence and Childhood Overweight with Kidney Cancer Mortality in Türkiye
- Circle of Willis Anatomical Variations on CT Angiography: Prevalence and Clinical Associations in a Turkish Cohort
- Torque Teno Virus Viremia in Complicated Staphylococcus aureus Infection: Prevalence, Viral Load, and Associations With Inflammatory Markers and Clinical Outcomes
- Physical activity, sleep duration, and multimorbidity: a cross-sectional study of prevalence associations and association rule mining of multimorbidity patterns
BibTeX
@article{iacopetta2026pase,
title = {{The PASE Study: The Prevalence and Associations of Bendopnoea in Patients with Pneumothorax.}},
author = {Bianca M Iacopetta and Niranjan Ananda Setty and Chloe Charlesworth and Michaela Donaghy and Carolyn J Peddle-McIntyre and Ai Ling Tan and Y C Gary Lee},
journal = {Advances in respiratory medicine},
year = {2026},
month = sep,
doi = {10.3390/arm94050068},
url = {https://europepmc.org/article/MED/42930046},
note = {CC BY},
}
RIS
TY - JOUR
TI - The PASE Study: The Prevalence and Associations of Bendopnoea in Patients with Pneumothorax.
AU - Bianca M Iacopetta
AU - Niranjan Ananda Setty
AU - Chloe Charlesworth
AU - Michaela Donaghy
AU - Carolyn J Peddle-McIntyre
AU - Ai Ling Tan
AU - Y C Gary Lee
PY - 2026
DA - 2026/09/22
JO - Advances in respiratory medicine
DO - 10.3390/arm94050068
UR - https://europepmc.org/article/MED/42930046
AB - Background: We recently established that bendopnoea (breathlessness upon bending forward) is common with pleural effusion; however, it has never been reported or investigated in patients with pneumothorax. This exploratory study investigated the prevalence and clinical relevance of bendopnoea in pneumothorax. Methods: Patients with pneumothorax of any aetiology or size were eligible. The presence of bendopnoea and time-to-bendopnoea was measured by bending the patient forward for 60 s and was assessed at baseline and post lung re-expansion. Results: Fifty patients (median age 48 years; 78% male) with primary spontaneous (48%), secondary spontaneous (24%) or iatrogenic (28%) pneumothorax were included. Pneumothorax size ranged from 7 to 99% of the hemithorax on chest radiographs. Most patients (74%) received conservative management. On a questionnaire, 48% (24/50) patients reported they experienced bendopnoea which "impacted daily life". When bent forward, 32% (16/50) developed bendopnoea within 60 s. Patients with bendopnoea reported more breathlessness than those without bendopnoea on a 100 mm Visual Analogue Scale (VAS): median 46 [Q1-Q3 = 25-54] vs. 12 [3-32] mm, respectively, p = 0.0089; median difference -23 mm (95% CI -35 to -6). Those with bendopnoea showed a signal with worse chest pain on a 100 mm VAS for pain: median 28 [13-48] vs. 10 [2-42] mm, p = 0.0528; median difference -15 mm (95% CI -27 to 0). Shorter time-to-bendopnoea (i.e., worse bendopnoea) correlated with worse breathlessness (rs = -0.38, 95% CI -0.6 to -0.1; p = 0.0072) and more severe chest pain (rs = -0.29, 95% CI -0.5 to -0.007; p = 0.039). Conclusions: Bendopnoea can occur with pneumothorax, correlates with breathlessness and demonstrates a signal with worse chest pain.
SN - 2451-4934
SN - 2543-6031
ER -