Combined Effects of Biomarkers in NLRP3 Inflammasome Axis and Cardiovascular Outcomes in Multivessels Disease.

@article{li2026combined,
  title = {{Combined Effects of Biomarkers in NLRP3 Inflammasome Axis and Cardiovascular Outcomes in Multivessels Disease.}},
  author = {Jiawen Li and Xiaozeng Wang and Zhenyu Liu and Zheng Zhang and Yongzhen Zhang and Zhifang Wang and Yingqing Feng and Qingsheng Wang and Xiaogang Guo and Xiaofang Tang and Jingjing Xu and Ying Song and Yan Chen and Na Xu and Yi Yao and Ru Liu and Pei Zhu and Yun Zhong and Wenchao Ou and Shiming Liu and Yaling Han and Jinqing Yuan and Xueyan Zhao},
  journal = {JACC. Asia},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jacasi.2026.06.040},
  url = {https://europepmc.org/article/MED/42841561},
  note = {CC BY-NC-ND},
}

TY  - JOUR
TI  - Combined Effects of Biomarkers in NLRP3 Inflammasome Axis and Cardiovascular Outcomes in Multivessels Disease.
AU  - Jiawen Li
AU  - Xiaozeng Wang
AU  - Zhenyu Liu
AU  - Zheng Zhang
AU  - Yongzhen Zhang
AU  - Zhifang Wang
AU  - Yingqing Feng
AU  - Qingsheng Wang
AU  - Xiaogang Guo
AU  - Xiaofang Tang
AU  - Jingjing Xu
AU  - Ying Song
AU  - Yan Chen
AU  - Na Xu
AU  - Yi Yao
AU  - Ru Liu
AU  - Pei Zhu
AU  - Yun Zhong
AU  - Wenchao Ou
AU  - Shiming Liu
AU  - Yaling Han
AU  - Jinqing Yuan
AU  - Xueyan Zhao
PY  - 2026
DA  - 2026/10/01
JO  - JACC. Asia
DO  - 10.1016/j.jacasi.2026.06.040
UR  - https://europepmc.org/article/MED/42841561
AB  - Background  Inflammation plays a crucial role in adverse outcomes of coronary artery disease. NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome activates 2 classical pathways: interleukin-1β (IL-1β)/IL-6/high-sensitivity C-reactive protein (hsCRP) and IL-18/IL-6/hsCRP. However, the predictive value of pathway-related biomarkers, particularly their combinations, remains to be systematically evaluated.Objectives  The authors aimed to explore the predictive value of individual and combined biomarkers from 2 pathways for long-term cardiovascular risk in patients with multivessel disease (MVD).Methods  From a prospective, multicenter cohort, 1,058 consecutive patients with MVD were enrolled. The primary endpoint was major adverse cardiac and cerebrovascular event (MACCE-4P), a composite of all-cause death, myocardial infarction, revascularization, and stroke.Results  During a median 2-year follow-up (IQR: 2.0-2.1 years), 130/1,058 (12.3%) MACCE-4P occurred. After multivariable adjustment, higher levels of IL-1β (HR: 1.63; 95% CI: 1.15-2.32), IL-6 (1.72, 1.20-2.46), and hsCRP (1.59, 1.09-2.30) were associated with increased MACCE-4P risk, whereas IL-18 was not. For combined analysis, any 2-biomarker combination from either the IL-1β/IL-6/hsCRP or IL-18/IL-6/hsCRP pathway significantly predicted higher MACCE-4P risk (HR range: 1.84-2.19), with further risk elevation observed for the 3-biomarker combinations (HR: 3.09; 95% CI: 1.80-5.31 for IL-1β pathway; HR: 2.26; 95% CI: 1.24-4.14 for IL-18 pathway). The 4-biomarker combination (IL-1β+IL-6+IL-18+hsCRP) also predicted significantly higher MACCE-4P risk (HR: 2.64; 95% CI: 1.36-5.14). Notably, 3-/4-combined biomarkers demonstrated significant incremental predictive value over single biomarkers.Conclusions  In patients with MVD, combined assessment of NLRP3-associated inflammatory biomarkers offers significant incremental predictive value beyond individual biomarkers. These findings highlight the importance of integrating multiple inflammatory biomarkers to better identify patients with residual inflammatory risk.
SN  - 2772-3747
ER  -