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Peer-reviewedCC BY-NC-NDAmerican journal of physiology. Cell physiology

Characterization of von Willebrand Factor-Enriched Extracellular Vesicles and Their Association with Platelet Adhesion in COVID-19

  • Ling Chen1
  • Aatish Mahajan1
  • Anil Kumar Ram1
  • Prabhakar Chalise2
  • Quan Zhang3
  • Huan Dong3
  • Zhijian Wu3
  • Liang Zheng3
  • X. Long Zheng3,4
  • Leslie Spikes1
  • Navneet Kaur Dhillon1,5
5 affiliations
  1. 1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160.
  2. 2Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS 66160.
  3. 3Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160.
  4. 4Institute of Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160.
  5. 5Department of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, KS 66160.
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Abstract

Circulating small extracellular vesicles in patients with COVID-19 carrying ultra-large VWF multimers boost platelet adhesion and activate endothelial cells, highlighting a potential driver and biomarker of COVID-19-associated coagulopathy.

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Cite

BibTeXRIS
BibTeX
@article{chen2026characterization,
  title = {{Characterization of von Willebrand Factor-Enriched Extracellular Vesicles and Their Association with Platelet Adhesion in COVID-19}},
  author = {Ling Chen and Aatish Mahajan and Anil Kumar Ram and Prabhakar Chalise and Quan Zhang and Huan Dong and Zhijian Wu and Liang Zheng and X. Long Zheng and Leslie Spikes and Navneet Kaur Dhillon},
  journal = {American journal of physiology. Cell physiology},
  year = {2026},
  month = oct,
  doi = {10.1152/ajpcell.00374.2026},
  url = {https://doi.org/10.1152/ajpcell.00374.2026},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Characterization of von Willebrand Factor-Enriched Extracellular Vesicles and Their Association with Platelet Adhesion in COVID-19
AU  - Ling Chen
AU  - Aatish Mahajan
AU  - Anil Kumar Ram
AU  - Prabhakar Chalise
AU  - Quan Zhang
AU  - Huan Dong
AU  - Zhijian Wu
AU  - Liang Zheng
AU  - X. Long Zheng
AU  - Leslie Spikes
AU  - Navneet Kaur Dhillon
PY  - 2026
DA  - 2026/10/13
JO  - American journal of physiology. Cell physiology
DO  - 10.1152/ajpcell.00374.2026
UR  - https://doi.org/10.1152/ajpcell.00374.2026
AB  - Circulating small extracellular vesicles in patients with COVID-19 carrying ultra-large VWF multimers boost platelet adhesion and activate endothelial cells, highlighting a potential driver and biomarker of COVID-19-associated coagulopathy.
SN  - 0363-6143
SN  - 1522-1563
ER  -