Comparative Radiobiological Evaluation of Radiotherapy Techniques Using Equivalent Uniform Dose, Tumor Control Probability, and Normal Tissue Complication Probability in Postmastectomy Breast Cancer
Abstract
Introduction: Postmastectomy radiotherapy plays a pivotal role in improving locoregional control and survival outcomes in early as well as in advanced-stage breast cancer patients. With the transition from conventional radiotherapy techniques to advanced intensity-modulated approaches, evaluation based solely on physical dose parameters is no longer sufficient. Radiobiological modelling provides a more clinically meaningful framework by quantifying tumor control and normal tissue complications. Objectives: The objective of this prospective study was to evaluate the radiobiological differences between three radiotherapy planning techniques, namely three-dimensional conformal radiotherapy (3DCRT), field-in-field forward planned intensity modulated radiotherapy (FIF-FP-IMRT), and inversely planned intensity modulated radiotherapy (IP-IMRT) in postmastectomy breast cancer patients. Materials and Methods: The present prospective study involved 150 postmastectomy breast cancer patients who have undergone chemotherapy treatment. Each patient was planned with three radiotherapy planning techniques, namely 3DCRT, FIF-FP-IMRT, and IP-IMRT for comparative radiobiological analysis. Radiobiological parameters, namely tumor control probability (TCP) and normal tissue complication probability (NTCP), were then calculated and compared for the three planning techniques. Results: The mean TCP values were comparable among all three techniques, with no statistically significant difference. However, significant differences were observed in most of the NTCP parameters (P < 0.05). Conclusion: The present study demonstrates that advanced radiotherapy planning techniques provide significant radiobiological advantages over conventional techniques in postmastectomy breast cancer patients. Among the three evaluated techniques, IP-IMRT showed the most favorable radiobiological profile, followed by FIF-FP-IMRT, while 3DCRT showed comparatively higher NTCP.
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BibTeX
@article{gaur2026comparative,
title = {{Comparative Radiobiological Evaluation of Radiotherapy Techniques Using Equivalent Uniform Dose, Tumor Control Probability, and Normal Tissue Complication Probability in Postmastectomy Breast Cancer}},
author = {Garima Gaur and Gurpreet Kaur and Baltej Singh and Pardeep Garg and Vinod Kumar Dangwal and Raja Paramjeet Singh Banipal},
journal = {Journal of Medical Physics},
year = {2026},
month = jul,
doi = {10.4103/jmp.jmp_106_26},
url = {https://doi.org/10.4103/jmp.jmp_106_26},
note = {CC BY-NC-SA},
}
RIS
TY - JOUR
TI - Comparative Radiobiological Evaluation of Radiotherapy Techniques Using Equivalent Uniform Dose, Tumor Control Probability, and Normal Tissue Complication Probability in Postmastectomy Breast Cancer
AU - Garima Gaur
AU - Gurpreet Kaur
AU - Baltej Singh
AU - Pardeep Garg
AU - Vinod Kumar Dangwal
AU - Raja Paramjeet Singh Banipal
PY - 2026
DA - 2026/07/01
JO - Journal of Medical Physics
DO - 10.4103/jmp.jmp_106_26
UR - https://doi.org/10.4103/jmp.jmp_106_26
AB - Introduction: Postmastectomy radiotherapy plays a pivotal role in improving locoregional control and survival outcomes in early as well as in advanced-stage breast cancer patients. With the transition from conventional radiotherapy techniques to advanced intensity-modulated approaches, evaluation based solely on physical dose parameters is no longer sufficient. Radiobiological modelling provides a more clinically meaningful framework by quantifying tumor control and normal tissue complications. Objectives: The objective of this prospective study was to evaluate the radiobiological differences between three radiotherapy planning techniques, namely three-dimensional conformal radiotherapy (3DCRT), field-in-field forward planned intensity modulated radiotherapy (FIF-FP-IMRT), and inversely planned intensity modulated radiotherapy (IP-IMRT) in postmastectomy breast cancer patients. Materials and Methods: The present prospective study involved 150 postmastectomy breast cancer patients who have undergone chemotherapy treatment. Each patient was planned with three radiotherapy planning techniques, namely 3DCRT, FIF-FP-IMRT, and IP-IMRT for comparative radiobiological analysis. Radiobiological parameters, namely tumor control probability (TCP) and normal tissue complication probability (NTCP), were then calculated and compared for the three planning techniques. Results: The mean TCP values were comparable among all three techniques, with no statistically significant difference. However, significant differences were observed in most of the NTCP parameters (P < 0.05). Conclusion: The present study demonstrates that advanced radiotherapy planning techniques provide significant radiobiological advantages over conventional techniques in postmastectomy breast cancer patients. Among the three evaluated techniques, IP-IMRT showed the most favorable radiobiological profile, followed by FIF-FP-IMRT, while 3DCRT showed comparatively higher NTCP.
SN - 0971-6203
SN - 1998-3913
ER -