Impact of the urinary microbiome on urinary tract infection progression.
- 1Students Scientific Club, Department of Urology, Medical University of Silesia in Katowice, Poland.
- 2Department of Urology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Abstract
Introduction
Urinary tract infections (UTIs) remain a significant challenge in modern urology, increasingly complicated by the shift away from the "sterile bladder dogma." This narrative review summarizes current knowledge (2020-2026) on the urinary microbiome in women, men, and children, emphasizing the transition toward personalized urological care.Material and methods
We conducted a comprehensive synthesis of 48 peer-reviewed articles from PubMed, Scopus, and Google Scholar. This narrative review evaluates the interplay between the urinary microbiome, host immune response, and pathogen virulence, while critically comparing traditional urine cultures with advanced diagnostic tools, such as next-generation sequencing (NGS) and expanded quantitative urine cultures (EQUC).Results
Our analysis highlights the role of dysbiosis in UTI progression and the increasing threat of multidrug-resistant pathogens within the ESKAPEE group. Findings reveal that while modern diagnostics offer a more detailed microbial profile, clinical implementation remains constrained by technical and standardization challenges.Conclusions
Standard urine culture may be insufficient for managing recurrent or atypical UTIs. We advocate for a personalized diagnostic and therapeutic approach that integrates molecular insights, aiming to curb antibiotic overuse and improve patient outcomes in the era of rising drug resistance.
Related
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- Impact of chlorhexidine gluconate on periurethral cleansing on catheter-associated urinary tract infection: a before-and-after quasi-experimental study at a tertiary care hospital.
- Machine learning-guided screening of urine cultures for urinary tract infection diagnosis according to AMCLI guidelines
- Impact of uterine fibroid surgery on lower urinary tract symptoms
- Intractable Diarrhea due to Enterovesical Fistula Caused by Recurrent Urinary Tract Infection with Bladder Outlet Obstruction: A Rare Clinical Presentation of "Urinary Diarrhea"
BibTeX
@article{domagala2026impact,
title = {{Impact of the urinary microbiome on urinary tract infection progression.}},
author = {Szymon Karol Domagała and Kamil Kania and Jakub Nocoń and Artur Spyrka and Mateusz Marcinek and Michał Tkocz},
journal = {Central European journal of urology},
year = {2026},
month = jun,
doi = {10.5173/ceju.2026.0083},
url = {https://europepmc.org/article/MED/42903643},
note = {CC BY-NC-SA},
}
RIS
TY - JOUR
TI - Impact of the urinary microbiome on urinary tract infection progression.
AU - Szymon Karol Domagała
AU - Kamil Kania
AU - Jakub Nocoń
AU - Artur Spyrka
AU - Mateusz Marcinek
AU - Michał Tkocz
PY - 2026
DA - 2026/06/30
JO - Central European journal of urology
DO - 10.5173/ceju.2026.0083
UR - https://europepmc.org/article/MED/42903643
AB - Introduction Urinary tract infections (UTIs) remain a significant challenge in modern urology, increasingly complicated by the shift away from the "sterile bladder dogma." This narrative review summarizes current knowledge (2020-2026) on the urinary microbiome in women, men, and children, emphasizing the transition toward personalized urological care.Material and methods We conducted a comprehensive synthesis of 48 peer-reviewed articles from PubMed, Scopus, and Google Scholar. This narrative review evaluates the interplay between the urinary microbiome, host immune response, and pathogen virulence, while critically comparing traditional urine cultures with advanced diagnostic tools, such as next-generation sequencing (NGS) and expanded quantitative urine cultures (EQUC).Results Our analysis highlights the role of dysbiosis in UTI progression and the increasing threat of multidrug-resistant pathogens within the ESKAPEE group. Findings reveal that while modern diagnostics offer a more detailed microbial profile, clinical implementation remains constrained by technical and standardization challenges.Conclusions Standard urine culture may be insufficient for managing recurrent or atypical UTIs. We advocate for a personalized diagnostic and therapeutic approach that integrates molecular insights, aiming to curb antibiotic overuse and improve patient outcomes in the era of rising drug resistance.
SN - 2080-4806
SN - 2080-4873
ER -