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Peer-reviewedCC BY 4.0Advanced Healthcare Materials

Protein‐Polymer Dynamic Hydrogels Utilizing Native Ligand Binding for Injectable Therapeutic Delivery and 3D Printing

  • S. Cem Millik1
  • Yonghui Wang2
  • Kefan Song2
  • Jessica M. Snyder3
  • LeAnn Le4
  • Lauren G. Brown1
  • Shanny Hsuan Kuo3
  • Ashleigh B. Theberge1,5
  • Suzie H. Pun2,4
  • Alshakim Nelson1,4
5 affiliations
  1. 1Department of Chemistry University of Washington Seattle Washington USA
  2. 2Department of Bioengineering University of Washington Seattle Washington USA
  3. 3Department of Comparative Medicine University of Washington Seattle Washington USA
  4. 4Molecular Engineering and Sciences Institute University of Washington Seattle Washington USA
  5. 5Department of Urology University of Washington Seattle Washington USA
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Abstract

Dynamic hydrogels comprising networks formed from reversible interactions have shown utility in minimally invasive delivery of encapsulated therapeutics, as well as in extrusion‐based 3D printing of tissue‐mimetic structures. Here, we report dynamic nanocolloidal hydrogels formed from the co‐assembly of spheroidal hyperbranched poly(glycerol) (HPG) and soluble albumin nanoparticles (SANs). Functionalization of the HPG with palmitate (a natural ligand of serum albumin) appears to enable self‐association of the HPG, as well as its interaction with SANs, to form dynamic networks. The properties of these networks can be tuned by modifying the size of the SAN in addition to other formulation parameters. To highlight the utility of these dynamic hydrogels, we demonstrate (i) in vitro and in vivo release of a model protein therapeutic from these injectable materials, (ii) preliminarily evaluate biocompatibility of these materials in a murine model, and (iii) demonstrate extrusion‐based 3D printing using these materials.

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Cite

BibTeXRIS
BibTeX
@article{millik2026proteinpolymer,
  title = {{Protein‐Polymer Dynamic Hydrogels Utilizing Native Ligand Binding for Injectable Therapeutic Delivery and 3D Printing}},
  author = {S. Cem Millik and Yonghui Wang and Kefan Song and Jessica M. Snyder and LeAnn Le and Lauren G. Brown and Shanny Hsuan Kuo and Ashleigh B. Theberge and Suzie H. Pun and Alshakim Nelson},
  journal = {Advanced Healthcare Materials},
  year = {2026},
  month = oct,
  doi = {10.1002/adhm.71810},
  url = {https://doi.org/10.1002/adhm.71810},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Protein‐Polymer Dynamic Hydrogels Utilizing Native Ligand Binding for Injectable Therapeutic Delivery and 3D Printing
AU  - S. Cem Millik
AU  - Yonghui Wang
AU  - Kefan Song
AU  - Jessica M. Snyder
AU  - LeAnn Le
AU  - Lauren G. Brown
AU  - Shanny Hsuan Kuo
AU  - Ashleigh B. Theberge
AU  - Suzie H. Pun
AU  - Alshakim Nelson
PY  - 2026
DA  - 2026/10/09
JO  - Advanced Healthcare Materials
DO  - 10.1002/adhm.71810
UR  - https://doi.org/10.1002/adhm.71810
AB  - Dynamic hydrogels comprising networks formed from reversible interactions have shown utility in minimally invasive delivery of encapsulated therapeutics, as well as in extrusion‐based 3D printing of tissue‐mimetic structures. Here, we report dynamic nanocolloidal hydrogels formed from the co‐assembly of spheroidal hyperbranched poly(glycerol) (HPG) and soluble albumin nanoparticles (SANs). Functionalization of the HPG with palmitate (a natural ligand of serum albumin) appears to enable self‐association of the HPG, as well as its interaction with SANs, to form dynamic networks. The properties of these networks can be tuned by modifying the size of the SAN in addition to other formulation parameters. To highlight the utility of these dynamic hydrogels, we demonstrate (i) in vitro and in vivo release of a model protein therapeutic from these injectable materials, (ii) preliminarily evaluate biocompatibility of these materials in a murine model, and (iii) demonstrate extrusion‐based 3D printing using these materials.
SN  - 2192-2640
SN  - 2192-2659
ER  -