Desmoplastic Malignant Mesothelioma of the Pericardium Mimicking Inflammatory Pericardial Disease: An Autopsy Case Report
Abstract
Desmoplastic malignant pericardial mesothelioma is an extremely rare subtype of malignant pericardial mesothelioma that is difficult to distinguish from inflammatory fibrous lesions. A 71-year-old man was admitted with a three-month history of progressive exertional dyspnea and chest tightness. His condition rapidly deteriorated, and he died on hospital day 3. Autopsy revealed bloody pericardial effusion and small epicardial nodules without distinct mass lesions. A histological examination revealed fibrous thickening containing scattered spindle-shaped and stellate atypical cells. The histological and immunohistochemical findings supported this diagnosis. In patients with subacute progressive heart failure of unclear cause, bloody pericardial effusion, or pericardial thickening, this disease should be considered in the differential diagnosis.
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BibTeX
@article{shingu2026desmoplastic,
title = {{Desmoplastic Malignant Mesothelioma of the Pericardium Mimicking Inflammatory Pericardial Disease: An Autopsy Case Report}},
author = {Manami Shingu and Takamasa Ohnishi and Yoshihito Horii and Hiroya Sakuramoto and Minoru Kishi and Hidekazu Tanaka},
journal = {Internal Medicine},
year = {2026},
month = sep,
doi = {10.2169/internalmedicine.7366-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7366-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Desmoplastic Malignant Mesothelioma of the Pericardium Mimicking Inflammatory Pericardial Disease: An Autopsy Case Report
AU - Manami Shingu
AU - Takamasa Ohnishi
AU - Yoshihito Horii
AU - Hiroya Sakuramoto
AU - Minoru Kishi
AU - Hidekazu Tanaka
PY - 2026
DA - 2026/09/08
JO - Internal Medicine
DO - 10.2169/internalmedicine.7366-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7366-26/_article
AB - Desmoplastic malignant pericardial mesothelioma is an extremely rare subtype of malignant pericardial mesothelioma that is difficult to distinguish from inflammatory fibrous lesions. A 71-year-old man was admitted with a three-month history of progressive exertional dyspnea and chest tightness. His condition rapidly deteriorated, and he died on hospital day 3. Autopsy revealed bloody pericardial effusion and small epicardial nodules without distinct mass lesions. A histological examination revealed fibrous thickening containing scattered spindle-shaped and stellate atypical cells. The histological and immunohistochemical findings supported this diagnosis. In patients with subacute progressive heart failure of unclear cause, bloody pericardial effusion, or pericardial thickening, this disease should be considered in the differential diagnosis.
SN - 1349-7235
SN - 0918-2918
ER -