Two New Metabolites from Moquiniastrum sordidum : Phytochemical Characterization and Multifaceted Bioactivity
4 affiliations
- 1Universidade Estadual de Maringá , , Av. Colombo 5790 , , ,
- 2Instituto de Ciências Biomédicas, Universidade de São Paulo , Av. Prof. Lineu Prestes , , ,
- 3Universidade Tecnológica Federal do Paraná , R. Cristo Rei, 19 , , ,
- 4Universidade Estadual de Ponta Grossa , , Av. Carlos Cavalcanti , , ,
Abstract
Recent taxonomic revisions based on molecular phylogenetics transferred species from Gochnatia to Moquiniastrum, which now includes 22 species, 20 of which occur in Brazil with an extra-Amazonian distribution. Here, we report a phytochemical study of Moquiniastrum sordidum (Less.) G. Sancho. Chromatographic separation afforded eight compounds, including two new metabolites: a sesquiterpene (5) and a phenolic glycoside (8). The known compounds were identified as simiarenol (1), oleanolic acid (2), hispidulin (3), tyrosol (4), genkwanin (6), and apigenin (7). The relative configuration of compound 5 was established using pip-HSQMBC-IPAP NMR, which afforded accurate long-range 2,3JCH coupling constants. Dereplication enabled the putative annotation of 45 metabolites: 12 flavonoids, 10 chlorogenic acid derivatives, 5 hydroxycinnamic acid derivatives, 9 terpenes, and 9 others. The biological potential of the extracts and isolated metabolites was evaluated using antioxidant, cytotoxic, antimicrobial, and antileishmanial assays. The new phenolic glycoside (8) showed potent antioxidant activity (ABTS: 1111 μmol TE g–1; FRAP: 4293 μmol Fe(II) g–1). Oleanolic acid (MIC = 130 μg mL–1) and apigenin (MIC = 30 μg mL–1) showed activity against the Gram-positive bacterium Bacillus cereus. Preliminary cytotoxic screening against HCT-116 cells showed that the dichloromethane fraction inhibited proliferation by 92% at 50 μg mL–1. Antileishmanial evaluation revealed moderate activity of the crude extract, which was significantly enhanced upon fractionation, with the dichloromethane fraction showing the highest activity against intracellular amastigotes (IC50 = 8.23 μg mL–1; SI = 7.87), indicating a selective antiparasitic effect.
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BibTeX
@article{cordeiro2026metabolites,
title = {{Two New Metabolites from Moquiniastrum sordidum : Phytochemical Characterization and Multifaceted Bioactivity}},
author = {Tamires Cordeiro and Francielli A. P. Valeze and Rodolfo B. Balbinot and Bianca D. B. Sahm and Fernanda F. Dourado and Elizabeth F. Pires and Aline Pivetta and Tatiana S. Tiuman and Celso V. Nakamura and Leticia V. Costa-Lotufo and Marta R. B. do Carmo and Renan V. Viesser and Ernani A. Basso and Maria H. Sarragiotto and Debora C. Baldoqui},
journal = {ACS Omega},
year = {2026},
month = oct,
doi = {10.1021/acsomega.6c06069},
url = {https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c06069/5454638/Two-New-Metabolites-from-Moquiniastrum-sordidum},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Two New Metabolites from Moquiniastrum sordidum : Phytochemical Characterization and Multifaceted Bioactivity
AU - Tamires Cordeiro
AU - Francielli A. P. Valeze
AU - Rodolfo B. Balbinot
AU - Bianca D. B. Sahm
AU - Fernanda F. Dourado
AU - Elizabeth F. Pires
AU - Aline Pivetta
AU - Tatiana S. Tiuman
AU - Celso V. Nakamura
AU - Leticia V. Costa-Lotufo
AU - Marta R. B. do Carmo
AU - Renan V. Viesser
AU - Ernani A. Basso
AU - Maria H. Sarragiotto
AU - Debora C. Baldoqui
PY - 2026
DA - 2026/10/20
JO - ACS Omega
DO - 10.1021/acsomega.6c06069
UR - https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c06069/5454638/Two-New-Metabolites-from-Moquiniastrum-sordidum
AB - Recent taxonomic revisions based on molecular phylogenetics transferred species from Gochnatia to Moquiniastrum, which now includes 22 species, 20 of which occur in Brazil with an extra-Amazonian distribution. Here, we report a phytochemical study of Moquiniastrum sordidum (Less.) G. Sancho. Chromatographic separation afforded eight compounds, including two new metabolites: a sesquiterpene (5) and a phenolic glycoside (8). The known compounds were identified as simiarenol (1), oleanolic acid (2), hispidulin (3), tyrosol (4), genkwanin (6), and apigenin (7). The relative configuration of compound 5 was established using pip-HSQMBC-IPAP NMR, which afforded accurate long-range 2,3JCH coupling constants. Dereplication enabled the putative annotation of 45 metabolites: 12 flavonoids, 10 chlorogenic acid derivatives, 5 hydroxycinnamic acid derivatives, 9 terpenes, and 9 others. The biological potential of the extracts and isolated metabolites was evaluated using antioxidant, cytotoxic, antimicrobial, and antileishmanial assays. The new phenolic glycoside (8) showed potent antioxidant activity (ABTS: 1111 μmol TE g–1; FRAP: 4293 μmol Fe(II) g–1). Oleanolic acid (MIC = 130 μg mL–1) and apigenin (MIC = 30 μg mL–1) showed activity against the Gram-positive bacterium Bacillus cereus. Preliminary cytotoxic screening against HCT-116 cells showed that the dichloromethane fraction inhibited proliferation by 92% at 50 μg mL–1. Antileishmanial evaluation revealed moderate activity of the crude extract, which was significantly enhanced upon fractionation, with the dichloromethane fraction showing the highest activity against intracellular amastigotes (IC50 = 8.23 μg mL–1; SI = 7.87), indicating a selective antiparasitic effect.
SN - 2470-1343
ER -