Gut microbiota profile in school-aged children with vitamin A depletion and vitamin E deficiency: A cross-sectional study.
7 affiliations
- 1Unidad Periférica de Investigación en Genómica de Poblaciones Aplicada a la Salud, Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México (UNAM)/Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, México.
- 2Departamento de Alimentos y Biotecnología, Facultad de Química, UNAM, Mexico City, México.
- 3Red de Manejo Biorracional de Plagas y Vectores, Instituto de Ecología, Clúster Científico y Tecnológico BioMimic, A.C.-INECOL, Veracruz, México.
- 4Laboratorio de Investigación de Alergia e Inmunología, Hospital Infantil de México Federico Gómez, Mexico City, México.
- 5Unidad de Investigación de Enfermedades Metabólicas/Departamento de Endocrinología y Metabolismo de Lípidos, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran (INCMNSZ), Mexico City, México.
- 6Laboratorio de Genómica Cardiovascular, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, México.
- 7Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro (UAQ), Querétaro, México.
Abstract
Vitamin A (VitA) and vitamin E (VitE) deficiencies can result in significant health consequences in children. The role of the intestinal microbiota in these vitamin deficiencies has been scarcely explored. This cross-sectional study aimed to analyze the relationship of VitA depletion and VitE deficiency with metabolic traits, dietary intake, and the gut microbiota composition in 179 school-age children. Serum VitA depletion and VitE deficiency were present in 8.4% and 20.7% of children, respectively. No significant relationship between tocopherol or retinol intake and VitA depletion or VitE deficiency was found. Linear discriminant analysis effect size (LEfSe) and analysis of compositions of microbiomes with bias correction 2 (ANCOM-BC2) analysis revealed no differences in the gut microbiota composition according to VitE status. However, we observed significant enrichment of Veillonella, Haemophilus, and Streptococcus in children with VitA depletion as compared to those with normal VitA levels. The enrichment of these oropharyngeal genera in VitA depletion resembles the gut microbiome composition previously described in childhood stunting. Future functional studies are required to elucidate whether these bacteria play a role in vitamin A metabolism.
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BibTeX
@article{lopezcontreras2026microbiota,
title = {{Gut microbiota profile in school-aged children with vitamin A depletion and vitamin E deficiency: A cross-sectional study.}},
author = {Blanca Estela López-Contreras and Paola León-Mimila and Hugo Villamil-Ramírez and Sofía Morán-Ramos and Daniel Cerqueda-García and Blanca E Del-Río-Navarro and Carlos A Aguilar-Salinas and Teresa Villarreal-Molina and Mariela Camacho-Barrón and Olga P García and Samuel Canizales-Quinteros},
journal = {Gut microbes reports},
year = {2026},
month = oct,
doi = {10.1080/29933935.2026.2747503},
url = {https://europepmc.org/article/MED/42903831},
note = {CC BY},
}
RIS
TY - JOUR
TI - Gut microbiota profile in school-aged children with vitamin A depletion and vitamin E deficiency: A cross-sectional study.
AU - Blanca Estela López-Contreras
AU - Paola León-Mimila
AU - Hugo Villamil-Ramírez
AU - Sofía Morán-Ramos
AU - Daniel Cerqueda-García
AU - Blanca E Del-Río-Navarro
AU - Carlos A Aguilar-Salinas
AU - Teresa Villarreal-Molina
AU - Mariela Camacho-Barrón
AU - Olga P García
AU - Samuel Canizales-Quinteros
PY - 2026
DA - 2026/10/16
JO - Gut microbes reports
DO - 10.1080/29933935.2026.2747503
UR - https://europepmc.org/article/MED/42903831
AB - Vitamin A (VitA) and vitamin E (VitE) deficiencies can result in significant health consequences in children. The role of the intestinal microbiota in these vitamin deficiencies has been scarcely explored. This cross-sectional study aimed to analyze the relationship of VitA depletion and VitE deficiency with metabolic traits, dietary intake, and the gut microbiota composition in 179 school-age children. Serum VitA depletion and VitE deficiency were present in 8.4% and 20.7% of children, respectively. No significant relationship between tocopherol or retinol intake and VitA depletion or VitE deficiency was found. Linear discriminant analysis effect size (LEfSe) and analysis of compositions of microbiomes with bias correction 2 (ANCOM-BC2) analysis revealed no differences in the gut microbiota composition according to VitE status. However, we observed significant enrichment of Veillonella, Haemophilus, and Streptococcus in children with VitA depletion as compared to those with normal VitA levels. The enrichment of these oropharyngeal genera in VitA depletion resembles the gut microbiome composition previously described in childhood stunting. Future functional studies are required to elucidate whether these bacteria play a role in vitamin A metabolism.
SN - 2993-3935
ER -