Dualistic Roles of MiR-215 in Digestive System Disorders: From Physiology to Pathology
- 1College of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China
Abstract
MicroRNA-215 (miR-215), a highly conserved non-coding small molecule, plays a significant regulatory role in the maintenance of cellular homeostasis, tissue and organ development, and the pathogenesis of various diseases. In recent years, accumulating evidence has revealed that miR-215 is extensively and complexly involved in digestive system diseases, drawing considerable attention due to its aberrant expression and functional diversity across multiple digestive organs. Notably, miR-215 can exert diametrically opposing biological functions in different digestive organs, and even within the same organ under distinct pathological contexts, underscoring its unique property as a “dual-functional small molecule” and providing an ideal paradigm for deciphering the regulatory complexity of microRNA networks. This review systematically summarizes the discovery and sequence conservation features of miR-215, with a particular focus on its differential expression patterns in major digestive organs. We further dissect the molecular mechanisms underlying its pathological context-dependent functional switching in intestinal disorders, gastric cancer, and hepatic lesions, and evaluate its potential utility as a biomarker for the diagnosis and prognosis of digestive tract diseases. Collectively, this review aims to provide a theoretical foundation and novel insights for the early detection, prognostic assessment, and precision-targeted therapy of digestive system disorders.
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BibTeX
@article{zhang2026dualistic,
title = {{Dualistic Roles of MiR-215 in Digestive System Disorders: From Physiology to Pathology}},
author = {Mao Zhang and Hailing Li and Jinna Yang and Xinyuan Lei and Shuang Gao and Yiming Yan and Hongyi Li},
journal = {Biomolecules},
year = {2026},
month = nov,
doi = {10.3390/biom16111583},
url = {https://www.mdpi.com/2218-273X/16/11/1583},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Dualistic Roles of MiR-215 in Digestive System Disorders: From Physiology to Pathology
AU - Mao Zhang
AU - Hailing Li
AU - Jinna Yang
AU - Xinyuan Lei
AU - Shuang Gao
AU - Yiming Yan
AU - Hongyi Li
PY - 2026
DA - 2026/11/01
JO - Biomolecules
DO - 10.3390/biom16111583
UR - https://www.mdpi.com/2218-273X/16/11/1583
AB - MicroRNA-215 (miR-215), a highly conserved non-coding small molecule, plays a significant regulatory role in the maintenance of cellular homeostasis, tissue and organ development, and the pathogenesis of various diseases. In recent years, accumulating evidence has revealed that miR-215 is extensively and complexly involved in digestive system diseases, drawing considerable attention due to its aberrant expression and functional diversity across multiple digestive organs. Notably, miR-215 can exert diametrically opposing biological functions in different digestive organs, and even within the same organ under distinct pathological contexts, underscoring its unique property as a “dual-functional small molecule” and providing an ideal paradigm for deciphering the regulatory complexity of microRNA networks. This review systematically summarizes the discovery and sequence conservation features of miR-215, with a particular focus on its differential expression patterns in major digestive organs. We further dissect the molecular mechanisms underlying its pathological context-dependent functional switching in intestinal disorders, gastric cancer, and hepatic lesions, and evaluate its potential utility as a biomarker for the diagnosis and prognosis of digestive tract diseases. Collectively, this review aims to provide a theoretical foundation and novel insights for the early detection, prognostic assessment, and precision-targeted therapy of digestive system disorders.
SN - 2218-273X
ER -