Diet-attributable vascular/metabolic disease burden comparisons and public health implications in Western Europe and North America
Abstract
Ischemic heart disease (IHD), ischemic stroke (IS), type 2 diabetes mellitus (T2DM), and lower-extremity vascular disease are leading causes of disability in Western Europe and North America, but their diet-attributable burden remains unclear. Using Global Burden of Disease (GBD) 2023 data, we assessed the association between the Socio-demographic Index (SDI) and the vascular/metabolic disease burden and compared the cross-regional burden through multi-dimensional time-trend, risk contribution, and projection analyses. Mendelian randomization (MR) tested causal diet effects on disease subtypes. Frontier analysis showed diet-related IHD and IS burden declined with SDI, while T2DM increased. By 2023, Western Europe had a lower burden than North America. Processed meat and whole grain dominated T2DM and IHD burden, respectively. Joinpoint analysis revealed declining trends. Projections to 2035 indicated North America remains higher. MR identified several potential causal links. This study provides a basis for vascular/metabolic disease prevention policies and dietary interventions in Western Europe and North America.
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BibTeX
@article{li2026dietattributable,
title = {{Diet-attributable vascular/metabolic disease burden comparisons and public health implications in Western Europe and North America}},
author = {Haonan Li and Jun Zhang and Zhixuan Liu and Junjie Li and Xingxiao Yin and Haodong Li and Yubo Lu and Qiang Xu and Junping Wang},
journal = {iScience},
year = {2026},
month = oct,
doi = {10.1016/j.isci.2026.117732},
url = {https://www.cell.com/iscience/fulltext/S2589-0042(26)03113-5},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Diet-attributable vascular/metabolic disease burden comparisons and public health implications in Western Europe and North America
AU - Haonan Li
AU - Jun Zhang
AU - Zhixuan Liu
AU - Junjie Li
AU - Xingxiao Yin
AU - Haodong Li
AU - Yubo Lu
AU - Qiang Xu
AU - Junping Wang
PY - 2026
DA - 2026/10/20
JO - iScience
DO - 10.1016/j.isci.2026.117732
UR - https://www.cell.com/iscience/fulltext/S2589-0042(26)03113-5
AB - Ischemic heart disease (IHD), ischemic stroke (IS), type 2 diabetes mellitus (T2DM), and lower-extremity vascular disease are leading causes of disability in Western Europe and North America, but their diet-attributable burden remains unclear. Using Global Burden of Disease (GBD) 2023 data, we assessed the association between the Socio-demographic Index (SDI) and the vascular/metabolic disease burden and compared the cross-regional burden through multi-dimensional time-trend, risk contribution, and projection analyses. Mendelian randomization (MR) tested causal diet effects on disease subtypes. Frontier analysis showed diet-related IHD and IS burden declined with SDI, while T2DM increased. By 2023, Western Europe had a lower burden than North America. Processed meat and whole grain dominated T2DM and IHD burden, respectively. Joinpoint analysis revealed declining trends. Projections to 2035 indicated North America remains higher. MR identified several potential causal links. This study provides a basis for vascular/metabolic disease prevention policies and dietary interventions in Western Europe and North America.
SN - 2589-0042
ER -