Peer-reviewedCC BY-NC-NDJACC. Asia
Elevated Lipoprotein(a) in Asian Populations and its Implications for Cardiovascular Disease.
16 affiliations
- 1Northern Health, Epping, Australia.
- 2Department of Endocrinology, Changi General Hospital, Singapore, Singapore.
- 3Division of Endocrinology and Metabolism, Department of Medicine, School of Clinical Medicine, Li KaShing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Queen Mary Hospital, Hong Kong SAR, China.
- 4Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University Kanazawa, Kanazawa, Japan.
- 5Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
- 6Ziauddin University Hospital, North Nazimabad, Karachi, Pakistan.
- 7Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
- 8Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.
- 9National University Heart Center Singapore, Singapore, Singapore.
- 10Fuwai Hospital, Beijing, China.
- 11Victorian Heart Institute, Monash University, Clayton, Australia.
- 12National Cerebral and Cardiovascular Center, Osaka, Japan.
- 13Kokilaben Hospital, Andheri West, Mumbai, India.
- 14Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia.
- 15Section of Cardiology, Department of Medicine, Aga Khan University, Karachi, Pakistan; Department of Population Health, Aga Khan University, Nairobi, Kenya.
- 16Departments of Medical Education and Medicine, Melbourne Medical School, University of Melbourne, Parkville, Australia. Electronic address: [email protected].
Abstract
Elevated lipoprotein (a) (Lp[a]) is becoming increasingly recognized as a cardiovascular disease risk factor. The relationship of Lp(a) to cardiovascular disease is well characterized in European populations; however, data are lacking in the Asian region. In this scoping review, we aimed to characterize the distribution and prevalence of elevated Lp(a) in the Asian region and its relationship to coronary artery disease, cerebrovascular disease, and peripheral vascular disease. Thirty-one Asian studies met the inclusion criteria and were compared with 6 representative European studies. The greatest representation was in Chinese populations, with much less representation of Japanese, Thai, Indian, and other groups. Levels of Lp(a) in healthy Asian populations were generally lower than in Europid (Caucasian) populations; however, these levels remain lower than those reported in European literature. Within Asian populations, elevated Lp(a) was universally associated with increased risk of coronary artery disease and peripheral vascular disease. The relationship with stroke was less clear.
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BibTeX
@article{damore2026elevated,
title = {{Elevated Lipoprotein(a) in Asian Populations and its Implications for Cardiovascular Disease.}},
author = {Matthew D'Amore and Wann Jia Loh and David Tak Wai Lui and Hayato Tada and Rungroj Krittayaphong and Khalida Soomro and Wael Almahmeed and Thushara Matthias and Kian Keong Poh and Jian Jun Li and Julie Butters and Yu Kataoka and Mayank Dalakoti and Jamshed J Dalal and Adam Nelson and Salim S Virani and Stephen J Nicholls and Richard C O'Brien},
journal = {JACC. Asia},
year = {2026},
month = oct,
doi = {10.1016/j.jacasi.2026.07.046},
url = {https://europepmc.org/article/MED/42841558},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Elevated Lipoprotein(a) in Asian Populations and its Implications for Cardiovascular Disease.
AU - Matthew D'Amore
AU - Wann Jia Loh
AU - David Tak Wai Lui
AU - Hayato Tada
AU - Rungroj Krittayaphong
AU - Khalida Soomro
AU - Wael Almahmeed
AU - Thushara Matthias
AU - Kian Keong Poh
AU - Jian Jun Li
AU - Julie Butters
AU - Yu Kataoka
AU - Mayank Dalakoti
AU - Jamshed J Dalal
AU - Adam Nelson
AU - Salim S Virani
AU - Stephen J Nicholls
AU - Richard C O'Brien
PY - 2026
DA - 2026/10/01
JO - JACC. Asia
DO - 10.1016/j.jacasi.2026.07.046
UR - https://europepmc.org/article/MED/42841558
AB - Elevated lipoprotein (a) (Lp[a]) is becoming increasingly recognized as a cardiovascular disease risk factor. The relationship of Lp(a) to cardiovascular disease is well characterized in European populations; however, data are lacking in the Asian region. In this scoping review, we aimed to characterize the distribution and prevalence of elevated Lp(a) in the Asian region and its relationship to coronary artery disease, cerebrovascular disease, and peripheral vascular disease. Thirty-one Asian studies met the inclusion criteria and were compared with 6 representative European studies. The greatest representation was in Chinese populations, with much less representation of Japanese, Thai, Indian, and other groups. Levels of Lp(a) in healthy Asian populations were generally lower than in Europid (Caucasian) populations; however, these levels remain lower than those reported in European literature. Within Asian populations, elevated Lp(a) was universally associated with increased risk of coronary artery disease and peripheral vascular disease. The relationship with stroke was less clear.
SN - 2772-3747
ER -