Can PIM-3 score predict risk for neonatal mortality vs. SNAPPE II and SNAP II scores in a tertiary surgical neonatal intensive care unit?
- 1Neonatal Intensive Care Unit, Great Ormond Street Hospital for Children, London, United Kingdom.
- 2Paediatric Intensive Care Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.
- 3Department of Infection, Immunity and Inflammation, University College London, London, United Kingdom.
Abstract
To assess the accuracy of PIM-3 score in predicting neonatal mortality by comparing it to two established neonatal mortality scores, SNAPPE II and SNAP II. Retrospective study of all admissions to Great Ormond Street Neonatal Intensive Care Unit (NICU) for the calendar year of 2022. Individual scores were calculated for all admissions using the electronic health records and referring or transfer notes. Admissions <12 h and those with missing data were excluded. The sensitivity and specificity of each score at potential cut-off values were calculated and plotted as a receiver operator curve (ROC), by calculating the Area Under the Curve (AUC) and confidence intervals for each one. score. Subgroup analysis was used to assess the AUC of each score for gender, prematurity, age at admission, gestational weight, ventilation status, and whether the admission was planned. The PIM-3 score had a higher AUC of 0.788 compared to SNAPPE II (0.738), and SNAP II (0.706), with optimal cut-off values at 9%, 30 and 11, respectively. The PIM-3 score performed better in preterm, lower birth weight and ventilated neonates. It also demonstrated a better correlation to length of stay compared to the other two scores, although statistically not significant. The PIM-3 score was equal to, or marginally better in predicting mortality in a mixed neonatal population compared to SNAPPE II and SNAP II. Further prospective analysis in a larger patient cohort is required to reproduce and validate its efficacy.
Related
- Incidence and predictors of early neonatal mortality among neonates admitted to neonatal intensive care units in public general hospitals in Northwest Ethiopia: a multicenter prospective cohort study.
- Physiotherapists’ knowledge and experiences of palliative care in neonatal intensive care units: a qualitative study Conhecimentos e vivência de fisioterapeutas sobre cuidados paliativos em unidade de terapia intensiva neonatal: um estudo qualitativo
- Developing the supportive care bundle for mothers of infants hospitalised in the neonatal intensive care unit: protocol for a multimethod study
- OP–049 Somalian mothers’ perspectives on breast milk while their infants are cared for in the neonatal intensive care unit: a qualitative study
- Addressing neonatal intensive care unit clinicians’ distress via interprofessional meetings
BibTeX
@article{atkinson2026pim3,
title = {{Can PIM-3 score predict risk for neonatal mortality vs. SNAPPE II and SNAP II scores in a tertiary surgical neonatal intensive care unit?}},
author = {Rachel Atkinson and Samiran Ray and Simon Hannam and Maria Chalia},
journal = {Frontiers in pediatrics},
year = {2026},
month = oct,
doi = {10.3389/fped.2026.1933189},
url = {https://europepmc.org/article/MED/42952883},
note = {CC BY},
}
RIS
TY - JOUR
TI - Can PIM-3 score predict risk for neonatal mortality vs. SNAPPE II and SNAP II scores in a tertiary surgical neonatal intensive care unit?
AU - Rachel Atkinson
AU - Samiran Ray
AU - Simon Hannam
AU - Maria Chalia
PY - 2026
DA - 2026/10/14
JO - Frontiers in pediatrics
DO - 10.3389/fped.2026.1933189
UR - https://europepmc.org/article/MED/42952883
AB - To assess the accuracy of PIM-3 score in predicting neonatal mortality by comparing it to two established neonatal mortality scores, SNAPPE II and SNAP II. Retrospective study of all admissions to Great Ormond Street Neonatal Intensive Care Unit (NICU) for the calendar year of 2022. Individual scores were calculated for all admissions using the electronic health records and referring or transfer notes. Admissions <12 h and those with missing data were excluded. The sensitivity and specificity of each score at potential cut-off values were calculated and plotted as a receiver operator curve (ROC), by calculating the Area Under the Curve (AUC) and confidence intervals for each one. score. Subgroup analysis was used to assess the AUC of each score for gender, prematurity, age at admission, gestational weight, ventilation status, and whether the admission was planned. The PIM-3 score had a higher AUC of 0.788 compared to SNAPPE II (0.738), and SNAP II (0.706), with optimal cut-off values at 9%, 30 and 11, respectively. The PIM-3 score performed better in preterm, lower birth weight and ventilated neonates. It also demonstrated a better correlation to length of stay compared to the other two scores, although statistically not significant. The PIM-3 score was equal to, or marginally better in predicting mortality in a mixed neonatal population compared to SNAPPE II and SNAP II. Further prospective analysis in a larger patient cohort is required to reproduce and validate its efficacy.
SN - 2296-2360
ER -