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PreprintCC BYChemRxiv

Electrochemical (3+2) Cycloaddition of Enamides and 4-(Bocamino)phenol for the Synthesis of 2-Aminodihydrobenzofurans

  • Maurice Peene1
  • Louis Rouseu1
  • Marios kidonakis1
  1. 1Organic and Macromolecular Chemistry, Gent University, Krijgslaan 281, Gent, Gent, Belgium, 9000
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Abstract

Synopsis: We report a simple electrochemical protocol to prepare 2-amino-dihydrobenzofurans from enamides. In contrast to previously reported approaches relying on stoichiometric chemical oxidants or transition metal catalysis of prefunctionalized compounds, the present method directly couples 4-(Boc-amino)phenol through anodic activation to a wide range of enamides, using inexpensive graphite electrodes in an undivided cell.

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Cite

BibTeXRIS
BibTeX
@misc{peene2026electrochemical,
  title = {{Electrochemical (3+2) Cycloaddition of Enamides and 4-(Bocamino)phenol for the Synthesis of 2-Aminodihydrobenzofurans}},
  author = {Maurice Peene and Louis Rouseu and Marios kidonakis},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010367/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010367/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Electrochemical (3+2) Cycloaddition of Enamides and 4-(Bocamino)phenol for the Synthesis of 2-Aminodihydrobenzofurans
AU  - Maurice Peene
AU  - Louis Rouseu
AU  - Marios kidonakis
PY  - 2026
DA  - 2026/10/13
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010367/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010367/v1
AB  - Synopsis: We report a simple electrochemical protocol to prepare 2-amino-dihydrobenzofurans from enamides. In contrast to previously reported approaches relying on stoichiometric chemical oxidants or transition metal catalysis of prefunctionalized compounds, the present method directly couples 4-(Boc-amino)phenol through anodic activation to a wide range of enamides, using inexpensive graphite electrodes in an undivided cell.
ER  -