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Peer-reviewedCC BYOrganic letters

Stereoselective Polyglucuronic Acid Assembly via the Iron-Catalyzed Stereospecific Glycosylation with Glycal Epoxides.

  • Xiao-Wen Zhang1
  • Zixiang Jiang1
  • Hao Xu1
  1. 1Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts02453, United States.
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Abstract

Polyglucuronic acids (PGAs) are directly involved in essential biological processes, but catalytic methods for stereoselective PGA synthesis are underdeveloped because glucuronic acid (GlcA) donors are intrinsically difficult to activate. We report herein a convergent and stereoselective PGA assembly method via iron-catalyzed iterative and stereospecific glycosylation with glycal epoxides. This method is effective in the assembly of an array of GlcA-β-1,4-GlcA linkages in complex glycans and readily provides PGA octasaccharides in high stereoselectivity.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026stereoselective,
  title = {{Stereoselective Polyglucuronic Acid Assembly via the Iron-Catalyzed Stereospecific Glycosylation with Glycal Epoxides.}},
  author = {Xiao-Wen Zhang and Zixiang Jiang and Hao Xu},
  journal = {Organic letters},
  year = {2026},
  month = oct,
  doi = {10.1021/acs.orglett.6c03166},
  url = {https://europepmc.org/article/MED/42917835},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Stereoselective Polyglucuronic Acid Assembly via the Iron-Catalyzed Stereospecific Glycosylation with Glycal Epoxides.
AU  - Xiao-Wen Zhang
AU  - Zixiang Jiang
AU  - Hao Xu
PY  - 2026
DA  - 2026/10/01
JO  - Organic letters
DO  - 10.1021/acs.orglett.6c03166
UR  - https://europepmc.org/article/MED/42917835
AB  - Polyglucuronic acids (PGAs) are directly involved in essential biological processes, but catalytic methods for stereoselective PGA synthesis are underdeveloped because glucuronic acid (GlcA) donors are intrinsically difficult to activate. We report herein a convergent and stereoselective PGA assembly method via iron-catalyzed iterative and stereospecific glycosylation with glycal epoxides. This method is effective in the assembly of an array of GlcA-β-1,4-GlcA linkages in complex glycans and readily provides PGA octasaccharides in high stereoselectivity.
SN  - 1523-7060
SN  - 1523-7052
ER  -