Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 9 min ago
Peer-reviewedCC BY 4.0Scientific Reports

Social support and HRQoL decline in cirrhosis: a 12-month cohort in China

  • Siyu Qiu
  • Liping Wang
  • Jiangping Ma
  • Chong Guan Ng
Open at sourcePDFDOICite

Abstract

Health-related quality of life (HRQoL) is important in cirrhosis, but which social support domains are associated with clinically meaningful decline and whether associations vary by compensation status remain uncertain. In this 12-month Chinese cohort, adults with hepatologist-confirmed cirrhosis completed the Duke Social Support Index at baseline. Social Network and Social Interaction were count-based, whereas Subjective and Instrumental Support ranged from 0 to 40 and 0–52. HRQoL was assessed using the Chronic Liver Disease Questionnaire at baseline and 12 months. The primary outcome was a decrease of at least 0.5 points in mean CLDQ. Firth logistic regression estimated adjusted associations; compensation-status-stratified and interaction analyses assessed heterogeneity. Robust linear regression examined continuous change. Among 567 participants (72.0% compensated), 111 (19.6%) had MCID-defined decline. MCID-defined decline occurred in 11.5% of participants with compensated cirrhosis and 40.3% of those with decompensated cirrhosis. Higher Subjective Support (adjusted OR 0.62 per 5 points; 95% CI 0.43–0.88) and Instrumental Support (adjusted OR 0.38 per 5 points; 95% CI 0.27–0.53) were associated with lower odds of decline, whereas higher MELD-Na was associated with higher odds (adjusted OR 1.32 per point; 95% CI 1.20–1.46). The Instrumental Support association differed by compensation status (interaction p < 0.001); continuous-change findings were consistent. Subjective and Instrumental Support were associated with more favorable 12-month HRQoL trajectories. Multicentre replication is needed before support-based screening or care pathways are considered for routine implementation.

Related

  1. Chain mediating effect of resilience and disease acceptance on social support and self-management behavior in patients with liver cirrhosis
    Songlan Sui, Manman Wu, Qian Yu +6
    Scientific ReportsPeer-reviewedCC BY-NC-ND 4.0Full textPsychiatry & mental healthCrossref
  2. Social isolation, self-perceived loneliness, and the 7-year trajectories of depression and cognitive decline: a prospective cohort study
    Yuting Shen, Yonghui Shen
    BMC Public HealthPeer-reviewedCC BY-NC-ND 4.0Epidemiology & public healthCrossref
  3. Stroke and cognitive decline: associations of social support and family connections in CHARLS and ELSA cohorts
    Mingdong Li, Kewei Xiao, Chaoli Song +1
    BMC Public HealthPeer-reviewedCC BY 4.0Full textPsychiatry & mental healthPMC
  4. Social support and cognition in a racially and ethnically diverse cohort: the role of neighborhood disadvantage
    Tasha Rhoads, Alec C. Neale, Kimberly Cobos +5
    Frontiers in NeurologyPeer-reviewedCC BY 4.0Full textNeurologyCrossrefPMC
  5. Acute Kidney Disease and Clinical Outcomes in Stable Outpatients With Decompensated Cirrhosis: A Prospective Cohort Study
    Vasileios Lekakis, Florence Wong, George Papatheodoridis +2
    Journal of Clinical and Experimental HepatologyPeer-reviewedLicence not statedFull textGeneral medicinePMC

Cite

BibTeXRIS
BibTeX
@article{qiu2026social,
  title = {{Social support and HRQoL decline in cirrhosis: a 12-month cohort in China}},
  author = {Siyu Qiu and Liping Wang and Jiangping Ma and Chong Guan Ng},
  journal = {Scientific Reports},
  year = {2026},
  month = oct,
  doi = {10.1038/s41598-026-74100-7},
  url = {https://www.nature.com/articles/s41598-026-74100-7},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Social support and HRQoL decline in cirrhosis: a 12-month cohort in China
AU  - Siyu Qiu
AU  - Liping Wang
AU  - Jiangping Ma
AU  - Chong Guan Ng
PY  - 2026
DA  - 2026/10/03
JO  - Scientific Reports
DO  - 10.1038/s41598-026-74100-7
UR  - https://www.nature.com/articles/s41598-026-74100-7
AB  - Health-related quality of life (HRQoL) is important in cirrhosis, but which social support domains are associated with clinically meaningful decline and whether associations vary by compensation status remain uncertain. In this 12-month Chinese cohort, adults with hepatologist-confirmed cirrhosis completed the Duke Social Support Index at baseline. Social Network and Social Interaction were count-based, whereas Subjective and Instrumental Support ranged from 0 to 40 and 0–52. HRQoL was assessed using the Chronic Liver Disease Questionnaire at baseline and 12 months. The primary outcome was a decrease of at least 0.5 points in mean CLDQ. Firth logistic regression estimated adjusted associations; compensation-status-stratified and interaction analyses assessed heterogeneity. Robust linear regression examined continuous change. Among 567 participants (72.0% compensated), 111 (19.6%) had MCID-defined decline. MCID-defined decline occurred in 11.5% of participants with compensated cirrhosis and 40.3% of those with decompensated cirrhosis. Higher Subjective Support (adjusted OR 0.62 per 5 points; 95% CI 0.43–0.88) and Instrumental Support (adjusted OR 0.38 per 5 points; 95% CI 0.27–0.53) were associated with lower odds of decline, whereas higher MELD-Na was associated with higher odds (adjusted OR 1.32 per point; 95% CI 1.20–1.46). The Instrumental Support association differed by compensation status (interaction p < 0.001); continuous-change findings were consistent. Subjective and Instrumental Support were associated with more favorable 12-month HRQoL trajectories. Multicentre replication is needed before support-based screening or care pathways are considered for routine implementation.
SN  - 2045-2322
ER  -