Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair
4 affiliations
- 1Department of Neurosurgery, National Regional Medical Center Binhai Campus of the First Affiliated Hospital Fujian Medical University Fuzhou Fujian China
- 2Department of Neurosurgery, Neurosurgery Research Institute The First Affiliated Hospital Fujian Medical University Fuzhou Fujian China
- 3Department of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China
- 4Department of Neurosurgery Fuzong Clinical Medical College of Fujian Medical University Fuzhou Fujian China
Abstract
Excessive accumulation of reactive oxygen species (ROS) impairs bone regeneration and angiogenesis in steroid‐induced osteonecrosis of the femoral head (SONFH), yet current antioxidant therapies remain limited by low catalytic efficiency and short duration. Single‐atom nanozymes (SANs), with their well‐defined structures and maximal atomic efficiency, show great potential for treating ROS‐induced diseases by mimicking natural enzymes. However, the strong binding between transition metal sites and electron‐donating intermediates (e.g., O*, OH*, OOH*) creates high energy barriers, limiting their catalytic activities. Herein, single‐atomic platinum is successfully embedded into CeO 2‐x to form CeO 2‐x /Pt SANI, which enhanced catalytic activity via an “island‐sea” synergistic effect. Leveraging the unique charge‐transfer structures and confinement effect of nanoislands, CeO 2‐x /Pt SANI exhibits superior enzymatic activities than CeO 2 , attribute to the island‐sea synergistic effect that facilitates strong electron transfer, as proved by density functional theory (DFT) calculations. DFT calculations further demonstrate that Pt incorporation increases oxygen vacancies and tunes the d‐band center toward the Fermi level, facilitating ROS adsorption and accelerating redox reactions. Single‐cell sequencing and experimental results confirm that CeO 2‐x /Pt SANI reprograms the oxidative microenvironment, leading to significant therapeutic effects in SONFH. This study provides insights into the rational design of an advanced “island‐sea” structured single‐atom nanozyme to optimize the catalytic activity.
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BibTeX
@article{zhu2026oxygen,
title = {{Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair}},
author = {Yang Zhu and Zehui Lv and Xuejie Cai and Penghui Wei and D. Y. Wang and Zi Wang and Ruoying Wang and Yuxing Wang and X L Yang and Yixin Bian and Jiawei Xu and Xisheng Weng and Liangfeng Wei},
journal = {Advanced Science},
year = {2026},
month = may,
doi = {10.1002/advs.75840},
url = {https://doi.org/10.1002/advs.75840},
note = {CC BY},
}
RIS
TY - JOUR
TI - Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair
AU - Yang Zhu
AU - Zehui Lv
AU - Xuejie Cai
AU - Penghui Wei
AU - D. Y. Wang
AU - Zi Wang
AU - Ruoying Wang
AU - Yuxing Wang
AU - X L Yang
AU - Yixin Bian
AU - Jiawei Xu
AU - Xisheng Weng
AU - Liangfeng Wei
PY - 2026
DA - 2026/05/26
JO - Advanced Science
DO - 10.1002/advs.75840
UR - https://doi.org/10.1002/advs.75840
AB - Excessive accumulation of reactive oxygen species (ROS) impairs bone regeneration and angiogenesis in steroid‐induced osteonecrosis of the femoral head (SONFH), yet current antioxidant therapies remain limited by low catalytic efficiency and short duration. Single‐atom nanozymes (SANs), with their well‐defined structures and maximal atomic efficiency, show great potential for treating ROS‐induced diseases by mimicking natural enzymes. However, the strong binding between transition metal sites and electron‐donating intermediates (e.g., O*, OH*, OOH*) creates high energy barriers, limiting their catalytic activities. Herein, single‐atomic platinum is successfully embedded into CeO 2‐x to form CeO 2‐x /Pt SANI, which enhanced catalytic activity via an “island‐sea” synergistic effect. Leveraging the unique charge‐transfer structures and confinement effect of nanoislands, CeO 2‐x /Pt SANI exhibits superior enzymatic activities than CeO 2 , attribute to the island‐sea synergistic effect that facilitates strong electron transfer, as proved by density functional theory (DFT) calculations. DFT calculations further demonstrate that Pt incorporation increases oxygen vacancies and tunes the d‐band center toward the Fermi level, facilitating ROS adsorption and accelerating redox reactions. Single‐cell sequencing and experimental results confirm that CeO 2‐x /Pt SANI reprograms the oxidative microenvironment, leading to significant therapeutic effects in SONFH. This study provides insights into the rational design of an advanced “island‐sea” structured single‐atom nanozyme to optimize the catalytic activity.
SN - 2198-3844
ER -