Lipoprotein and inflammatory glycoprotein profiles in women with polycystic ovary syndrome alone or in association with type 1 diabetes
4 affiliations
- 1Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal
- 2Grupo de Investigación en Diabetes, Obesidad y Reproducción Humana, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) & Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos I
- 3Laboratory of Hormonology, Ghent University Hospital
- 4Department of Endocrinology, Ghent University Hospital
Abstract
We aimed to assess the influence of polycystic ovary syndrome (PCOS) on lipoprotein and inflammatory glycoprotein profiles in women with type 1 diabetes (T1D), and to determine differences between women with T1D and PCOS and women with PCOS alone. In a cross-sectional study, 147 premenopausal women with T1D were recruited from a Diabetes clinic at a tertiary hospital in Madrid, Spain. Women were subgrouped into T1D with PCOS (n = 30) and without PCOS (n = 117). Additionally, we compared women with T1D and PCOS (n = 30) with non-T1D women and normoglycemic PCOS (NGT-PCOS, n = 249), or abnormal glucose tolerance PCOS (AGT-PCOS, n = 44). Lipoprotein and inflammatory glycoproteins were assessed by proton nuclear magnetic resonance spectroscopy (1H-NMRS). We observed no differences regarding lipoprotein and glycoprotein profiles between T1D women with and without PCOS. Women with typical PCOS had higher VLDL-C, VLDL-TG, and VLDL-P, lower HDL-C and smaller LDL than women with T1D and PCOS. Smaller HDL particles were highest in T1D-PCOS. Inflammatory glycoproteins were significantly increased in T1D and PCOS and AGT-PCOS compared to NGT-PCOS. 1H-NMRS assessment showed that PCOS did not worsen the circulating lipoprotein and inflammatory glycoprotein profiles of T1D women. Among women with PCOS, those with T1D associated the most harmful HDL particle subclasses.
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BibTeX
@article{cebada2026lipoprotein,
title = {{Lipoprotein and inflammatory glycoprotein profiles in women with polycystic ovary syndrome alone or in association with type 1 diabetes}},
author = {Ane Bayona Cebada and Arturo Vega-Beyhart and María Insenser and M. Ángeles Martínez-García and Lía Nattero-Chávez and Esther De la Calle De la Villa and Beatriz Dorado Avendaño and Tom Fiers and Jean-Marc Kaufman and Héctor F. Escobar-Morreale and Manuel Luque-Ramírez},
journal = {Scientific Reports},
year = {2026},
month = jul,
doi = {10.1038/s41598-026-62157-3},
url = {https://doi.org/10.1038/s41598-026-62157-3},
note = {CC BY},
}
RIS
TY - JOUR
TI - Lipoprotein and inflammatory glycoprotein profiles in women with polycystic ovary syndrome alone or in association with type 1 diabetes
AU - Ane Bayona Cebada
AU - Arturo Vega-Beyhart
AU - María Insenser
AU - M. Ángeles Martínez-García
AU - Lía Nattero-Chávez
AU - Esther De la Calle De la Villa
AU - Beatriz Dorado Avendaño
AU - Tom Fiers
AU - Jean-Marc Kaufman
AU - Héctor F. Escobar-Morreale
AU - Manuel Luque-Ramírez
PY - 2026
DA - 2026/07/01
JO - Scientific Reports
DO - 10.1038/s41598-026-62157-3
UR - https://doi.org/10.1038/s41598-026-62157-3
AB - We aimed to assess the influence of polycystic ovary syndrome (PCOS) on lipoprotein and inflammatory glycoprotein profiles in women with type 1 diabetes (T1D), and to determine differences between women with T1D and PCOS and women with PCOS alone. In a cross-sectional study, 147 premenopausal women with T1D were recruited from a Diabetes clinic at a tertiary hospital in Madrid, Spain. Women were subgrouped into T1D with PCOS (n = 30) and without PCOS (n = 117). Additionally, we compared women with T1D and PCOS (n = 30) with non-T1D women and normoglycemic PCOS (NGT-PCOS, n = 249), or abnormal glucose tolerance PCOS (AGT-PCOS, n = 44). Lipoprotein and inflammatory glycoproteins were assessed by proton nuclear magnetic resonance spectroscopy (1H-NMRS). We observed no differences regarding lipoprotein and glycoprotein profiles between T1D women with and without PCOS. Women with typical PCOS had higher VLDL-C, VLDL-TG, and VLDL-P, lower HDL-C and smaller LDL than women with T1D and PCOS. Smaller HDL particles were highest in T1D-PCOS. Inflammatory glycoproteins were significantly increased in T1D and PCOS and AGT-PCOS compared to NGT-PCOS. 1H-NMRS assessment showed that PCOS did not worsen the circulating lipoprotein and inflammatory glycoprotein profiles of T1D women. Among women with PCOS, those with T1D associated the most harmful HDL particle subclasses.
SN - 2045-2322
ER -