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Peer-reviewedCC BYOpen life sciences

Mechanism of the crude extract from the whole herb of Plantago asiatica L. in alleviating lower limb ischemia-reperfusion injury

  • Jiangpeng Wu1
  • Shenmei Wu1
  • Jun Lv1
  • Mengjiao Zhu1
  • Jin Peng2
  • Chuanzhu Li1
  • Teng Gao1
  • Guiyun Jin1
  • Tang Deng1
  1. 1Department of Interventional Radiology and Vascular Surgery, Key Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China
  2. 2Department of Radiology, Hainan Modern Women and Children’s Hospital, Haikou 570311, China
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Abstract

This study evaluated the protective effects of Plantago asiatica L. (PAL) extract against acute lower limb ischemia-reperfusion injury (LL-IRI). Network pharmacology and molecular docking identified core targets associated with inflammation, oxidative stress, and apoptosis and indicated stable interactions betweenPAL constituents and these targets. In vivo, PAL improved skeletal muscle pathology and ultrastructural injury in LL-IRI rats, reduced interleukin-1β (IL-1β) and malondialdehyde (MDA) levels, restored superoxide dismutase (SOD) and catalase (CAT) activities and Bcl-2 expression, and suppressed Bax and cleaved Caspase-3. In vitro, PAL promoted the proliferation and migration of lipopolysaccharide (LPS)-injured C2C12 cells, stabilized mitochondrial membrane potential, and modulated apoptosis-related proteins. These findings support the view that PAL protects against LL-IRI by attenuating inflammation and oxidative stress and by regulating apoptosis.

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Cite

BibTeXRIS
BibTeX
@article{wu2026mechanism,
  title = {{Mechanism of the crude extract from the whole herb of Plantago asiatica L. in alleviating lower limb ischemia-reperfusion injury}},
  author = {Jiangpeng Wu and Shenmei Wu and Jun Lv and Mengjiao Zhu and Jin Peng and Chuanzhu Li and Teng Gao and Guiyun Jin and Tang Deng},
  journal = {Open life sciences},
  year = {2026},
  month = nov,
  doi = {10.1515/biol-2025-1381},
  url = {https://europepmc.org/article/PMC/PMC13726666},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Mechanism of the crude extract from the whole herb of Plantago asiatica L. in alleviating lower limb ischemia-reperfusion injury
AU  - Jiangpeng Wu
AU  - Shenmei Wu
AU  - Jun Lv
AU  - Mengjiao Zhu
AU  - Jin Peng
AU  - Chuanzhu Li
AU  - Teng Gao
AU  - Guiyun Jin
AU  - Tang Deng
PY  - 2026
DA  - 2026/11/02
JO  - Open life sciences
DO  - 10.1515/biol-2025-1381
UR  - https://europepmc.org/article/PMC/PMC13726666
AB  - This study evaluated the protective effects of Plantago asiatica L. (PAL) extract against acute lower limb ischemia-reperfusion injury (LL-IRI). Network pharmacology and molecular docking identified core targets associated with inflammation, oxidative stress, and apoptosis and indicated stable interactions betweenPAL constituents and these targets. In vivo, PAL improved skeletal muscle pathology and ultrastructural injury in LL-IRI rats, reduced interleukin-1β (IL-1β) and malondialdehyde (MDA) levels, restored superoxide dismutase (SOD) and catalase (CAT) activities and Bcl-2 expression, and suppressed Bax and cleaved Caspase-3. In vitro, PAL promoted the proliferation and migration of lipopolysaccharide (LPS)-injured C2C12 cells, stabilized mitochondrial membrane potential, and modulated apoptosis-related proteins. These findings support the view that PAL protects against LL-IRI by attenuating inflammation and oxidative stress and by regulating apoptosis.
SN  - 2391-5412
ER  -