Effects of Oral Resveratrol Supplementation on Inflammatory and Cardiometabolic Outcomes in Adults: Protocol for a Systematic Review and Meta-Analysis.
4 affiliations
- 1Departamento de Ciencias Preclínicas, Facultad de Medicina, Universidad Católica del Maule, Avda San Miguel 3605, Talca, Maule, Chile, 56 712968000.
- 2Servicio de Medicina Física y Rehabilitación, Hospital San Juan de Dios de Curicó, Servicio de Salud del Maule, Curicó, Maule, Chile.
- 3Carrera de Medicina, Facultad de Medicina, Universidad Católica del Maule, Talca, Maule, Chile.
- 4Sistema de Bibliotecas, Universidad Católica del Maule, Talca, Maule, Chile.
Abstract
Background
Resveratrol is a naturally occurring polyphenol found primarily in grapes, berries, peanuts, and red wine. Experimental evidence suggests that resveratrol modulates multiple biological pathways involved in oxidative stress, inflammation, insulin signaling, endothelial function, and metabolic homeostasis. However, findings from randomized controlled trials remain inconsistent, and previous evidence syntheses have reported substantial clinical and methodological heterogeneity.Objective
This is a protocol for a systematic review and meta-analysis that will provide an updated synthesis of randomized controlled trials evaluating the effects of oral resveratrol supplementation on inflammatory biomarkers and cardiometabolic outcomes in adults while exploring potential methodological and biological sources of heterogeneity.Methods
This protocol was developed according to the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols) statement and prospectively registered in PROSPERO. Randomized controlled trials comparing oral resveratrol supplementation with placebo, other nutritional supplements, or no intervention in adults will be eligible. Literature searches will be conducted in the PubMed, Cochrane CENTRAL, Scopus, Web of Science, and SciELO databases. Two reviewers will independently perform study selection, data extraction, and risk-of-bias assessment using the Cochrane risk of bias 2 tool. The certainty of evidence will be assessed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach.Results
During peer review, the search strategy was refined before initiation of the formal review. As of August 2026, the formal systematic review had not yet commenced. The literature search and study selection are scheduled to begin on September 1, 2026, and the systematic review is expected to be completed by April 2027, with dissemination of the findings anticipated thereafter.Conclusions
This systematic review and meta-analysis protocol is expected to provide an updated and transparent synthesis of the available randomized evidence regarding the effects of oral resveratrol supplementation on inflammatory biomarkers and cardiometabolic outcomes in adults.
Related
- Implementation strategies, outcomes and determinants of integrated care for cardiometabolic conditions and mental, neurological and substance use disorders: protocol for a mixed-methods systematic review
- Early-life risk factors and cardiometabolic outcomes in children and adolescents: a systematic review and meta-analysis
- Physical activity interventions for cardiometabolic and psychosocial outcomes in people living with HIV in sub Saharan Africa: A systematic review
- Examining the links between vitamin C and schizophrenia spectrum disorders: a systematic review and meta-analysis on circulating levels and supplementation outcomes.
- Synthesized cardiometabolic, pulmonary, and sleep outcomes after bariatric surgery in adolescents with severe obesity: A systematic review and meta-analysis
BibTeX
@article{herrerasantelices2026effects,
title = {{Effects of Oral Resveratrol Supplementation on Inflammatory and Cardiometabolic Outcomes in Adults: Protocol for a Systematic Review and Meta-Analysis.}},
author = {Andrea Herrera-Santelices and Josefa Camila Núñez Rivas and Francisca P Rubio-Molina and Ileana González Bonet},
journal = {JMIR research protocols},
year = {2026},
month = oct,
doi = {10.2196/101301},
url = {https://europepmc.org/article/MED/42954150},
note = {CC BY},
}
RIS
TY - JOUR
TI - Effects of Oral Resveratrol Supplementation on Inflammatory and Cardiometabolic Outcomes in Adults: Protocol for a Systematic Review and Meta-Analysis.
AU - Andrea Herrera-Santelices
AU - Josefa Camila Núñez Rivas
AU - Francisca P Rubio-Molina
AU - Ileana González Bonet
PY - 2026
DA - 2026/10/27
JO - JMIR research protocols
DO - 10.2196/101301
UR - https://europepmc.org/article/MED/42954150
AB - Background Resveratrol is a naturally occurring polyphenol found primarily in grapes, berries, peanuts, and red wine. Experimental evidence suggests that resveratrol modulates multiple biological pathways involved in oxidative stress, inflammation, insulin signaling, endothelial function, and metabolic homeostasis. However, findings from randomized controlled trials remain inconsistent, and previous evidence syntheses have reported substantial clinical and methodological heterogeneity.Objective This is a protocol for a systematic review and meta-analysis that will provide an updated synthesis of randomized controlled trials evaluating the effects of oral resveratrol supplementation on inflammatory biomarkers and cardiometabolic outcomes in adults while exploring potential methodological and biological sources of heterogeneity.Methods This protocol was developed according to the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols) statement and prospectively registered in PROSPERO. Randomized controlled trials comparing oral resveratrol supplementation with placebo, other nutritional supplements, or no intervention in adults will be eligible. Literature searches will be conducted in the PubMed, Cochrane CENTRAL, Scopus, Web of Science, and SciELO databases. Two reviewers will independently perform study selection, data extraction, and risk-of-bias assessment using the Cochrane risk of bias 2 tool. The certainty of evidence will be assessed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach.Results During peer review, the search strategy was refined before initiation of the formal review. As of August 2026, the formal systematic review had not yet commenced. The literature search and study selection are scheduled to begin on September 1, 2026, and the systematic review is expected to be completed by April 2027, with dissemination of the findings anticipated thereafter.Conclusions This systematic review and meta-analysis protocol is expected to provide an updated and transparent synthesis of the available randomized evidence regarding the effects of oral resveratrol supplementation on inflammatory biomarkers and cardiometabolic outcomes in adults.
SN - 1929-0748
ER -