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Peer-reviewedCC BY-NC 4.0International Journal of Surgical Pathology

Prognostic Significance of Cellular Cannibalism in Colorectal Tumors

  • Sumru Cagaptay1
  • Anil Aysal Agalar1
  • Ozgul Sagol1
  • Ilknur Gorken2
  • Ilkay Tugba Unek3
  • Hulya Ellidokuz4
  • Funda Barlik5
  • Selman Sokmen6
  • Sulen Sarioglu7
7 affiliations
  1. 1Department of Medical Pathology, Faculty of Medicine, Dokuz Eylul University, Izmır, Turkey
  2. 2Department of Radiation Oncology, Faculty of Medicine, Dokuz Eylul University, Izmır, Turkey
  3. 3Department of Medical Oncology, Faculty of Medicine, Dokuz Eylul University, Izmır, Turkey
  4. 4Department of Preventive Oncology, Faculty of Medicine, Dokuz Eylul University, Izmır, Turkey
  5. 5Department of Radiodiagnostics, Faculty of Medicine, Dokuz Eylul University, Izmır, Turkey
  6. 6Department of General Surgery, Faculty of Medicine, Dokuz Eylul University, Izmır, Turkey
  7. 7Department of Medical Pathology, Memorial Healthcare Group, Istanbul, Turkey
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Abstract

Background: Various cell-in-cell interactions are thought to be related to the aggressiveness, degree of anaplasia, invasiveness, and metastatic potential of a malignancy. One of these cellular interactions is cellular cannibalism (CC). In our study, we investigated the value of using CC as a prospective additional criterion for determining the prognosis of patients with colorectal carcinomas. We also aimed to identify potential clinical and histopathological markers, as well as molecular connections, that may be associated with CC. Methods: The hematoxylin-eosin-stained slides of the 232 patients diagnosed with colorectal adenocarcinoma were evaluated for the presence and degree of CC. The relationships between CC and demographic, and histopathological parameters, microsatellite instability status, and KRAS mutation status were evaluated statistically. Additionally, the prognostic significance of CC was investigated via multivariate analysis. Results: The relationships between high pT and pN stages and CC were statistically significant (P < .001). A significant association was found between lymphovascular invasion, perineural invasion, and CC (P < .001). Conclusions: CC was associated with poor colorectal cancer outcomes in our study. Therefore, we believe that it is important to identify and quantify cannibal cells during routine histopathology examinations to demonstrate their morphological predictive value.

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Cite

BibTeXRIS
BibTeX
@article{cagaptay2026prognostic,
  title = {{Prognostic Significance of Cellular Cannibalism in Colorectal Tumors}},
  author = {Sumru Cagaptay and Anil Aysal Agalar and Ozgul Sagol and Ilknur Gorken and Ilkay Tugba Unek and Hulya Ellidokuz and Funda Barlik and Selman Sokmen and Sulen Sarioglu},
  journal = {International Journal of Surgical Pathology},
  year = {2026},
  month = jun,
  doi = {10.1177/10668969261457881},
  url = {https://doi.org/10.1177/10668969261457881},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Prognostic Significance of Cellular Cannibalism in Colorectal Tumors
AU  - Sumru Cagaptay
AU  - Anil Aysal Agalar
AU  - Ozgul Sagol
AU  - Ilknur Gorken
AU  - Ilkay Tugba Unek
AU  - Hulya Ellidokuz
AU  - Funda Barlik
AU  - Selman Sokmen
AU  - Sulen Sarioglu
PY  - 2026
DA  - 2026/06/30
JO  - International Journal of Surgical Pathology
DO  - 10.1177/10668969261457881
UR  - https://doi.org/10.1177/10668969261457881
AB  - Background: Various cell-in-cell interactions are thought to be related to the aggressiveness, degree of anaplasia, invasiveness, and metastatic potential of a malignancy. One of these cellular interactions is cellular cannibalism (CC). In our study, we investigated the value of using CC as a prospective additional criterion for determining the prognosis of patients with colorectal carcinomas. We also aimed to identify potential clinical and histopathological markers, as well as molecular connections, that may be associated with CC. Methods: The hematoxylin-eosin-stained slides of the 232 patients diagnosed with colorectal adenocarcinoma were evaluated for the presence and degree of CC. The relationships between CC and demographic, and histopathological parameters, microsatellite instability status, and KRAS mutation status were evaluated statistically. Additionally, the prognostic significance of CC was investigated via multivariate analysis. Results: The relationships between high pT and pN stages and CC were statistically significant (P < .001). A significant association was found between lymphovascular invasion, perineural invasion, and CC (P < .001). Conclusions: CC was associated with poor colorectal cancer outcomes in our study. Therefore, we believe that it is important to identify and quantify cannibal cells during routine histopathology examinations to demonstrate their morphological predictive value.
SN  - 1066-8969
SN  - 1940-2465
ER  -