Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 59 min ago
Peer-reviewedCC BY-NC-NDNature Aging

Aging disrupts spatiotemporal coordination in the cycling murine ovary

  • Tammy C. T. Lan1,2
  • Alison Kochersberger3
  • Ruth Raichur2
  • Sophia Szady4
  • Hien Tran4,5
  • Radiana Simeonova4,5
  • Ashley Helmuth4
  • Andrew Minagar4,5
  • Maria José Orozco Fuentes4
  • Vipin Kumar2
  • Giovanni J. Marrero2
  • Irving Barrera2
7 more authors
  • Sarah M. Mangiameli2
  • Alex K. Shalek6,7,8,9,2
  • Pardis Christine Sabeti10,11,12,2
  • Fei Chen13,2
  • David S. Fischer14,15,16
  • Jennifer L. Garrison17,18,19,20
  • Hattie Chung21,22,23,24,25
25 affiliations
  1. 1Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
  2. 2The Broad Institute of MIT and Harvard, Cambridge, MA, USA
  3. 3Buck Institute for Research on Aging, Novato, CA, USA
  4. 4Department of Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA
  5. 5Yale College, New Haven, CT, USA
  6. 6Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA
  7. 7Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA
  8. 8Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
  9. 9Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA
  10. 10Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA
  11. 11Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA
  12. 12Howard Hughes Medical Institute, Chevy Chase, MD, USA
  13. 13Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA
  14. 14Medical University of Vienna, Comprehensive Center for Artificial Intelligence in Medicine, Vienna, Austria. [email protected]
  15. 15The Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected]
  16. 16University of Vienna, Institute of Artificial Intelligence, Center for Medical Data Science, Vienna, Austria. [email protected]
  17. 17Buck Institute for Research on Aging, Novato, CA, USA. [email protected]
  18. 18Center for Healthy Aging in Women, Novato, CA, USA. [email protected]
  19. 19Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA. [email protected]
  20. 20Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. [email protected]
  21. 21Department of Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA. [email protected]
  22. 22Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA. [email protected]
  23. 23Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA. [email protected]
  24. 24The Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected]
  25. 25Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA. [email protected]
Open at sourceDOICite

Abstract

Ovarian cycles of follicle development, ovulation and tissue regeneration require cooperative functions of constituent cells. Here the authors provide a spatial atlas of the aging mouse ovary, revealing that reproductive decline reflects progressive loss of spatiotemporal coordination, linking altered cellular dynamics, tissue remodeling and inflammation across the ovary.

Related

  1. Alcohol disrupts spatial coordination of autophagy–lysosome pathways to impair intestinal barrier integrity
    Murugadas Anbazhagan, Ahmed Bakheet, John D. Dickinson +4
    eBioMedicinePeer-reviewedCC BY 4.0Full textEpidemiology & public healthCrossrefPMC
  2. Matrix metalloproteinase imaging and survival prospects with aging in murine aortic aneurysm.
    Mean Ghim, Onur Varli, Azmi A Ahmad +13
    EJNMMI researchPeer-reviewedCC BYFull textMedical imaging & radiologyEurope PMC
  3. Tamoxifen transiently disrupts estrous cyclicity without altering long-term ovarian aging trajectories
    S. Badillo, E. Poljanska, S. Ray +7
    bioRxivPreprintCC BYFull textPhysiologybioRxiv
  4. Elevated fasting glucose and triglycerides in combined oral contraceptive users compared to naturally cycling females
    Claire Karaguesian, Jennifer S. Williams, Maureen J. MacDonald +1
    Physiological reportsPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. Development of a Single Thermal Cycling Multiplex RT-qPCR Assay for Rapid Arbovirus Detection
    Róger J. Costa, Andreas Stocker, Cleyde Marconi +6
    Diagnostics (Basel, Switzerland)Peer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{lan2026aging,
  title = {{Aging disrupts spatiotemporal coordination in the cycling murine ovary}},
  author = {Tammy C. T. Lan and Alison Kochersberger and Ruth Raichur and Sophia Szady and Hien Tran and Radiana Simeonova and Ashley Helmuth and Andrew Minagar and Maria José Orozco Fuentes and Vipin Kumar and Giovanni J. Marrero and Irving Barrera and Sarah M. Mangiameli and Alex K. Shalek and Pardis Christine Sabeti and Fei Chen and David S. Fischer and Jennifer L. Garrison and Hattie Chung},
  journal = {Nature Aging},
  year = {2026},
  month = jun,
  doi = {10.1038/s43587-026-01140-z},
  url = {https://doi.org/10.1038/s43587-026-01140-z},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Aging disrupts spatiotemporal coordination in the cycling murine ovary
AU  - Tammy C. T. Lan
AU  - Alison Kochersberger
AU  - Ruth Raichur
AU  - Sophia Szady
AU  - Hien Tran
AU  - Radiana Simeonova
AU  - Ashley Helmuth
AU  - Andrew Minagar
AU  - Maria José Orozco Fuentes
AU  - Vipin Kumar
AU  - Giovanni J. Marrero
AU  - Irving Barrera
AU  - Sarah M. Mangiameli
AU  - Alex K. Shalek
AU  - Pardis Christine Sabeti
AU  - Fei Chen
AU  - David S. Fischer
AU  - Jennifer L. Garrison
AU  - Hattie Chung
PY  - 2026
DA  - 2026/06/17
JO  - Nature Aging
DO  - 10.1038/s43587-026-01140-z
UR  - https://doi.org/10.1038/s43587-026-01140-z
AB  - Ovarian cycles of follicle development, ovulation and tissue regeneration require cooperative functions of constituent cells. Here the authors provide a spatial atlas of the aging mouse ovary, revealing that reproductive decline reflects progressive loss of spatiotemporal coordination, linking altered cellular dynamics, tissue remodeling and inflammation across the ovary.
SN  - 2662-8465
ER  -