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Peer-reviewedCC BY-NC-NDGynecologic oncology

The Duffy-Null genotype and epithelial ovarian cancer survival in a cohort of Black women

  • Joellen M. Schildkraut1
  • Jeffrey R. Marks2
  • Lauren C. Peres3
  • Xintian Song1
  • Anthony J. Alberg4
  • Katherine A. Lawson-Michod5,6
  • Courtney E. Johnson1
  • Lindsay J. Collin1
  • Jennifer A. Doherty7
  • Elisa V. Bandera8
  • Melissa L. Bondy9
  • Theresa A. Hastert10
7 more authors
  • Michele L. Coté11
  • Edward S. Peters12
  • Kristin Haller1
  • Paul D. Terry13
  • Michael P. Epstein14
  • Yao Xin15
  • Andrew B. Lawson15,16
16 affiliations
  1. 1Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA
  2. 2Department of Surgery, Duke University School of Medicine, Durham, NC, USA
  3. 3Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA
  4. 4Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
  5. 5Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington.
  6. 6Department of Epidemiology, University of Washington, Seattle, Washington
  7. 7Department of Population Health Sciences and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah USA
  8. 8Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute, New Brunswick, NJ, USA
  9. 9Department of Epidemiology, Stanford University, Palo Alto CA, USA
  10. 10Wayne State University, School of Medicine, Karmanos Cancer Institute Detroit MI
  11. 11Department of Epidemiology, Indiana University Simon Comprehensive Cancer Center, Indianapolis, IN USA
  12. 12University of Nebraska Medical Center, College of Public Health, Department of Epidemiology Omaha Nebraska, USA
  13. 13Tennessee Medical Center Knoxville, TN USA
  14. 14Department of Human Genetics, Emory University, Atlanta, GA USA
  15. 15Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA
  16. 16Usher Institute, School of Medicine, University of Edinburgh, Edinburgh, UK
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Abstract

OBJECTIVE: Black women experience poor survival from epithelial ovarian cancer (EOC) for all stages at diagnosis and histotypes. The contribution of an ancestry-related genotype in the Atypical Chemokine Receptor 1 (ACKR1) gene to mortality after an EOC diagnosis in Black women has not been previously reported. METHODS: The relationship between the Duffy-null genotype (CC) in the ACKR1 gene and overall post-enrollment mortality in 408 Black women with EOC, including 275 with high-grade serous ovarian cancer (HGSC) was evaluated using Bayesian modeling approach to estimate hazard ratios (HR) and 95% credible intervals (CI) adjusting for stage, age at diagnosis, socioeconomic factors, and ovarian cancer family history. Tumor immune and genetic features were generated from sequencing assays on subsets of the HGSC cases. RESULTS: The CC genotype was associated with reduced all-cause mortality among EOC cases (adjusted HR = 0.60, 95% CI: 0.36-0.99). Among HGSC, the CC genotype was associated with higher African origin, lower ACKR1 expression (p = 0.049), lower cytotoxic T cell abundance (p = 0.062), and a higher frequency of homologous recombination deficient (HRD) tumors (p = 0.051). CONCLUSIONS: In this study, the Duffy-null CC genotype was associated with 40% lower EOC all-cause mortality in Black women. These are hypothesis-generating findings that require replication and further inquiry into mechanisms.

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Cite

BibTeXRIS
BibTeX
@article{schildkraut2026duffynull,
  title = {{The Duffy-Null genotype and epithelial ovarian cancer survival in a cohort of Black women}},
  author = {Joellen M. Schildkraut and Jeffrey R. Marks and Lauren C. Peres and Xintian Song and Anthony J. Alberg and Katherine A. Lawson-Michod and Courtney E. Johnson and Lindsay J. Collin and Jennifer A. Doherty and Elisa V. Bandera and Melissa L. Bondy and Theresa A. Hastert and Michele L. Coté and Edward S. Peters and Kristin Haller and Paul D. Terry and Michael P. Epstein and Yao Xin and Andrew B. Lawson},
  journal = {Gynecologic oncology},
  year = {2026},
  month = oct,
  doi = {10.1016/j.ygyno.2026.10.024},
  url = {https://doi.org/10.1016/j.ygyno.2026.10.024},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - The Duffy-Null genotype and epithelial ovarian cancer survival in a cohort of Black women
AU  - Joellen M. Schildkraut
AU  - Jeffrey R. Marks
AU  - Lauren C. Peres
AU  - Xintian Song
AU  - Anthony J. Alberg
AU  - Katherine A. Lawson-Michod
AU  - Courtney E. Johnson
AU  - Lindsay J. Collin
AU  - Jennifer A. Doherty
AU  - Elisa V. Bandera
AU  - Melissa L. Bondy
AU  - Theresa A. Hastert
AU  - Michele L. Coté
AU  - Edward S. Peters
AU  - Kristin Haller
AU  - Paul D. Terry
AU  - Michael P. Epstein
AU  - Yao Xin
AU  - Andrew B. Lawson
PY  - 2026
DA  - 2026/10/28
JO  - Gynecologic oncology
DO  - 10.1016/j.ygyno.2026.10.024
UR  - https://doi.org/10.1016/j.ygyno.2026.10.024
AB  - OBJECTIVE: Black women experience poor survival from epithelial ovarian cancer (EOC) for all stages at diagnosis and histotypes. The contribution of an ancestry-related genotype in the Atypical Chemokine Receptor 1 (ACKR1) gene to mortality after an EOC diagnosis in Black women has not been previously reported. METHODS: The relationship between the Duffy-null genotype (CC) in the ACKR1 gene and overall post-enrollment mortality in 408 Black women with EOC, including 275 with high-grade serous ovarian cancer (HGSC) was evaluated using Bayesian modeling approach to estimate hazard ratios (HR) and 95% credible intervals (CI) adjusting for stage, age at diagnosis, socioeconomic factors, and ovarian cancer family history. Tumor immune and genetic features were generated from sequencing assays on subsets of the HGSC cases. RESULTS: The CC genotype was associated with reduced all-cause mortality among EOC cases (adjusted HR = 0.60, 95% CI: 0.36-0.99). Among HGSC, the CC genotype was associated with higher African origin, lower ACKR1 expression (p = 0.049), lower cytotoxic T cell abundance (p = 0.062), and a higher frequency of homologous recombination deficient (HRD) tumors (p = 0.051). CONCLUSIONS: In this study, the Duffy-null CC genotype was associated with 40% lower EOC all-cause mortality in Black women. These are hypothesis-generating findings that require replication and further inquiry into mechanisms.
SN  - 0090-8258
SN  - 1095-6859
ER  -