Maternal kidney disease and composite kidney outcomes in the offspring.
7 affiliations
- 1Department of Pharmacy, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.
- 2Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
- 3School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
- 4Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
- 5Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
- 6Division of Pediatric Cardiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
- 7Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Abstract
Maternal chronic kidney disease (CKD) is associated with adverse pregnancy outcomes, but its relationship with long-term offspring kidney health remains uncertain. This retrospective maternal-child cohort study examined whether maternal CKD or reduced kidney function before or during pregnancy was associated with a composite kidney outcome in offspring. Live births in the Taiwan Mother and Child Health cohort from 2007 to 2017 were followed through 2018. In the primary cohort, maternal kidney disease was defined as claims-based CKD meeting chronicity criteria before or during pregnancy; the maternal eGFR subcohort additionally included eGFR-defined reduced kidney function. The primary outcome comprised ICD-defined CKD, reduced eGFR <60 mL/min/1.73 m² or ≥30% eGFR decline at age ≥2 years, or kidney replacement therapy. Laboratory components were interpreted as reduced kidney function rather than definitive CKD unless diagnostic chronicity was documented. Models adjusted for maternal, pregnancy, offspring, and perinatal covariates. Among 79,036 children, 4,687 (5.9%) met the composite kidney outcome. Maternal kidney disease was associated with modestly higher odds of the composite outcome (aOR, 1.29; 95% CI, 1.00-1.66) and offspring all-cause mortality (aOR, 1.88; 95% CI, 1.15-3.09). Analyses of individual components of the composite outcome, sex-stratified subgroups, and trimester-specific exposure windows were exploratory, imprecise, and not adjusted for multiplicity. Maternal CKD or reduced kidney function may identify dyads who warrant long-term kidney surveillance, although causal pathways require confirmation.
Related
- Preconception maternal infection-related exposures and risk of congenital heart disease in offspring: evidence from a large population-based cohort in South China
- Kidney Outcomes in Offspring Exposed to Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis
- Composite Blood-Count Inflammatory Indices in Diabetic Kidney Disease and Advanced, Largely Dialysis-Dependent Non-Diabetic Chronic Kidney Disease: A Single-Centre, Four-Group Cross-Sectional Study
- Redefining success in assisted reproductive technologies: the Embryo-Maternal-Offspring Continuum Framework
- Association Between Urine pH and Kidney Outcomes in Patients with Biopsy-Proven Kidney Disease
BibTeX
@article{hsu2026maternal,
title = {{Maternal kidney disease and composite kidney outcomes in the offspring.}},
author = {Chien-Ning Hsu and Lung-Chih Li and Shao-Ju Chien and You-Lin Tain},
journal = {Renal failure},
year = {2026},
month = oct,
doi = {10.1080/0886022x.2026.2745220},
url = {https://europepmc.org/article/MED/42902631},
note = {CC BY},
}
RIS
TY - JOUR
TI - Maternal kidney disease and composite kidney outcomes in the offspring.
AU - Chien-Ning Hsu
AU - Lung-Chih Li
AU - Shao-Ju Chien
AU - You-Lin Tain
PY - 2026
DA - 2026/10/20
JO - Renal failure
DO - 10.1080/0886022x.2026.2745220
UR - https://europepmc.org/article/MED/42902631
AB - Maternal chronic kidney disease (CKD) is associated with adverse pregnancy outcomes, but its relationship with long-term offspring kidney health remains uncertain. This retrospective maternal-child cohort study examined whether maternal CKD or reduced kidney function before or during pregnancy was associated with a composite kidney outcome in offspring. Live births in the Taiwan Mother and Child Health cohort from 2007 to 2017 were followed through 2018. In the primary cohort, maternal kidney disease was defined as claims-based CKD meeting chronicity criteria before or during pregnancy; the maternal eGFR subcohort additionally included eGFR-defined reduced kidney function. The primary outcome comprised ICD-defined CKD, reduced eGFR <60 mL/min/1.73 m² or ≥30% eGFR decline at age ≥2 years, or kidney replacement therapy. Laboratory components were interpreted as reduced kidney function rather than definitive CKD unless diagnostic chronicity was documented. Models adjusted for maternal, pregnancy, offspring, and perinatal covariates. Among 79,036 children, 4,687 (5.9%) met the composite kidney outcome. Maternal kidney disease was associated with modestly higher odds of the composite outcome (aOR, 1.29; 95% CI, 1.00-1.66) and offspring all-cause mortality (aOR, 1.88; 95% CI, 1.15-3.09). Analyses of individual components of the composite outcome, sex-stratified subgroups, and trimester-specific exposure windows were exploratory, imprecise, and not adjusted for multiplicity. Maternal CKD or reduced kidney function may identify dyads who warrant long-term kidney surveillance, although causal pathways require confirmation.
SN - 0886-022X
SN - 1525-6049
ER -