Association Between Serum 25-Hydroxyvitamin D Status and Long-Term Marginal Bone Loss Around Dental Implants
- 1Department of Periodontolgy, Faculty of Dentistry, Inonu University, 44280 Malatya, Turkey
Abstract
Background and Objectives: The objective was to evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] measured before functional loading and long-term peri-implant marginal bone loss (MBL). Materials and Methods: This retrospective study included 60 systemically healthy patients with 136 implants. Patients were classified as vitamin D-deficient (<20 ng/mL; n = 30) or -sufficient (≥20 ng/mL; n = 30). MBL was calculated from periapical radiographs obtained at prosthetic delivery and final follow-up (mean, 39.46 months; range, 34–48 months). Clinical parameters and implant loss were secondary outcomes. Between-group comparisons used the Mann–Whitney U and Fisher’s exact tests; associations were examined using Spearman’s rank correlation. Results: MBL was greater in the deficient group than in the sufficient group (0.98 ± 0.25 mm vs. 0.42 ± 0.32 mm; p < 0.001). Serum 25(OH)D was inversely correlated with MBL in the deficient group (rs = −0.720), sufficient group (rs = −0.604), and overall sample (rs = −0.862; all p < 0.001). No statistically significant between-group differences were detected in the clinical parameters (all p > 0.05). Conclusions: Lower baseline serum 25(OH)D was associated with greater long-term MBL, while clinical parameters and patient-level implant loss did not differ between groups.
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BibTeX
@article{ozen2026association,
title = {{Association Between Serum 25-Hydroxyvitamin D Status and Long-Term Marginal Bone Loss Around Dental Implants}},
author = {Okan Özen and Vesile Elif Toy},
journal = {Journal of Clinical Medicine},
year = {2026},
month = oct,
doi = {10.3390/jcm15197719},
url = {https://www.mdpi.com/2077-0383/15/19/7719},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Association Between Serum 25-Hydroxyvitamin D Status and Long-Term Marginal Bone Loss Around Dental Implants
AU - Okan Özen
AU - Vesile Elif Toy
PY - 2026
DA - 2026/10/07
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15197719
UR - https://www.mdpi.com/2077-0383/15/19/7719
AB - Background and Objectives: The objective was to evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] measured before functional loading and long-term peri-implant marginal bone loss (MBL). Materials and Methods: This retrospective study included 60 systemically healthy patients with 136 implants. Patients were classified as vitamin D-deficient (<20 ng/mL; n = 30) or -sufficient (≥20 ng/mL; n = 30). MBL was calculated from periapical radiographs obtained at prosthetic delivery and final follow-up (mean, 39.46 months; range, 34–48 months). Clinical parameters and implant loss were secondary outcomes. Between-group comparisons used the Mann–Whitney U and Fisher’s exact tests; associations were examined using Spearman’s rank correlation. Results: MBL was greater in the deficient group than in the sufficient group (0.98 ± 0.25 mm vs. 0.42 ± 0.32 mm; p < 0.001). Serum 25(OH)D was inversely correlated with MBL in the deficient group (rs = −0.720), sufficient group (rs = −0.604), and overall sample (rs = −0.862; all p < 0.001). No statistically significant between-group differences were detected in the clinical parameters (all p > 0.05). Conclusions: Lower baseline serum 25(OH)D was associated with greater long-term MBL, while clinical parameters and patient-level implant loss did not differ between groups.
SN - 2077-0383
ER -