Gastric schwannoma: a case report.
- 1Department of Upper Gastrointestinal Surgery, Concord Repatriation General Hospital, Hospital Road, Concord, NSW 2139, Australia.
Abstract
Gastric schwannomas are rare, benign mesenchymal tumours that closely mimic gastrointestinal stromal tumours (GISTs) on imaging, despite fundamentally different biological behaviour. We report a 74-year-old man with a background of proctocolectomy for rectal cancer, found incidentally to have a 5 cm exophytic gastric mass on surveillance gastroscopy. Endoscopic ultrasound-guided fine needle aspiration favoured schwannoma, and the patient underwent an uncomplicated laparoscopic gastric wedge resection. Histopathology confirmed gastric schwannoma with clear margins and no nodal involvement; immunohistochemistry was positive for S100 calcium-binding protein (S100)/SRY-box transcription factor 10 (SOX10) and negative for discovered on GIST-1 (DOG1)/CD117 (c-KIT)/smooth muscle actin (SMA)/desmin, excluding GIST. He recovered well and was discharged after 2 days, with a conservative surveillance endoscopy plan (6 months, then annually for 5 years) agreed at multidisciplinary team meeting. This case underscores the essential role of immunohistochemistry in distinguishing gastric schwannoma from GIST, and highlights the absence of a consensus surveillance protocol following resection.
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BibTeX
@article{haniff2026gastric,
title = {{Gastric schwannoma: a case report.}},
author = {Mohamed Tariq Haniff and Andrew Tse and Guillermo Becerril-Martinez},
journal = {Journal of surgical case reports},
year = {2026},
month = oct,
doi = {10.1093/jscr/rjag927},
url = {https://europepmc.org/article/MED/42898930},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Gastric schwannoma: a case report.
AU - Mohamed Tariq Haniff
AU - Andrew Tse
AU - Guillermo Becerril-Martinez
PY - 2026
DA - 2026/10/19
JO - Journal of surgical case reports
DO - 10.1093/jscr/rjag927
UR - https://europepmc.org/article/MED/42898930
AB - Gastric schwannomas are rare, benign mesenchymal tumours that closely mimic gastrointestinal stromal tumours (GISTs) on imaging, despite fundamentally different biological behaviour. We report a 74-year-old man with a background of proctocolectomy for rectal cancer, found incidentally to have a 5 cm exophytic gastric mass on surveillance gastroscopy. Endoscopic ultrasound-guided fine needle aspiration favoured schwannoma, and the patient underwent an uncomplicated laparoscopic gastric wedge resection. Histopathology confirmed gastric schwannoma with clear margins and no nodal involvement; immunohistochemistry was positive for S100 calcium-binding protein (S100)/SRY-box transcription factor 10 (SOX10) and negative for discovered on GIST-1 (DOG1)/CD117 (c-KIT)/smooth muscle actin (SMA)/desmin, excluding GIST. He recovered well and was discharged after 2 days, with a conservative surveillance endoscopy plan (6 months, then annually for 5 years) agreed at multidisciplinary team meeting. This case underscores the essential role of immunohistochemistry in distinguishing gastric schwannoma from GIST, and highlights the absence of a consensus surveillance protocol following resection.
SN - 2042-8812
ER -