Pseudoxanthoma Elasticum Treated with Endoscopic Clip Hemostasis for Upper Gastrointestinal Bleeding from a Dieulafoy Lesion
Abstract
A 30-year-old woman with upper gastrointestinal bleeding from a Dieulafoy lesion was treated using endoscopic hemostasis. A subsequent interview revealed that she had pseudoxanthoma elasticum (PXE) with an ABCC6 gene mutation, but she had not been under medical care for many years. The lesion was considered to be associated with PXE. Cirsoid aneurysms, characteristic of PXE, were observed during follow-up esophagogastroduodenoscopy. Systemic examinations revealed characteristic PXE findings in the skin and eyes, but no coronary or cerebrovascular abnormalities. This case highlights the need for a comprehensive evaluation of upper gastrointestinal bleeding cases, particularly those with a Dieulafoy lesion suggestive of an underlying systemic disorder.
Related
- Risk-based pathology reporting after endoscopic submucosal dissection for early gastrointestinal cancer: international consensus standards
- Beyond the Bite: Tick Salivary Proteins Targeting Hemostasis and Inflammation; Implications for Cardiovascular Disease
- Pitfalls and challenges in endoscopic assessment of ulcerative colitis.
- Flexible Endoscopic Transaqueductal Fenestration of Fourth Ventricular Arachnoid Cysts Combined with Endoscopic Third Ventriculostomy: A Technical Note
- Prevalence of Gastrointestinal Parasites in Goats and Sheep in Mbula Kuli, Adamawa State, Nigeria
BibTeX
@article{kaji2026pseudoxanthoma,
title = {{Pseudoxanthoma Elasticum Treated with Endoscopic Clip Hemostasis for Upper Gastrointestinal Bleeding from a Dieulafoy Lesion}},
author = {Ryosuke Kaji and Akiko Ohno and Jun Miyoshi and Ryutaro Sumi and Shiori Tsubata and Takahiro Shirakawa and Moegi Watanabe and Naohiko Miyamoto and Mitsunori Kusuhara and Maiko Kurata and Keiko Kataoka and Annabelle A. Okada and Minoru Matsuura and Tadakazu Hisamatsu},
journal = {Internal Medicine},
year = {2026},
month = nov,
doi = {10.2169/internalmedicine.6566-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6566-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Pseudoxanthoma Elasticum Treated with Endoscopic Clip Hemostasis for Upper Gastrointestinal Bleeding from a Dieulafoy Lesion
AU - Ryosuke Kaji
AU - Akiko Ohno
AU - Jun Miyoshi
AU - Ryutaro Sumi
AU - Shiori Tsubata
AU - Takahiro Shirakawa
AU - Moegi Watanabe
AU - Naohiko Miyamoto
AU - Mitsunori Kusuhara
AU - Maiko Kurata
AU - Keiko Kataoka
AU - Annabelle A. Okada
AU - Minoru Matsuura
AU - Tadakazu Hisamatsu
PY - 2026
DA - 2026/11/01
JO - Internal Medicine
DO - 10.2169/internalmedicine.6566-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6566-25/_article
AB - A 30-year-old woman with upper gastrointestinal bleeding from a Dieulafoy lesion was treated using endoscopic hemostasis. A subsequent interview revealed that she had pseudoxanthoma elasticum (PXE) with an ABCC6 gene mutation, but she had not been under medical care for many years. The lesion was considered to be associated with PXE. Cirsoid aneurysms, characteristic of PXE, were observed during follow-up esophagogastroduodenoscopy. Systemic examinations revealed characteristic PXE findings in the skin and eyes, but no coronary or cerebrovascular abnormalities. This case highlights the need for a comprehensive evaluation of upper gastrointestinal bleeding cases, particularly those with a Dieulafoy lesion suggestive of an underlying systemic disorder.
SN - 1349-7235
SN - 0918-2918
ER -