Volatile Biomarkers in Exhaled Breath for In Vivo Lipid Peroxidation and Ferroptosis Detection
Abstract
Human breath volatile metabolites have attracted increasing attention as a source of non-invasive biomarkers. However, the biosynthetic pathways of most breath-borne compounds remain unclear, and their relationships to physiological or pathological states are still poorly defined, which has greatly hindered the clini cal application of breath biomarkers.Ferroptosis is an iron-dependent process driven by lipid peroxidation that exacerbates tissue inflammation and has been implicated in a wide range of age-associated disorders. Importantly, some oxidized lipids generated during ferroptosis are volatile and can be released in exhaled breath. Based on this principle, we have developed a non-invasive strategy for detecting deep-tissue ferroptosis using exhaled volatile oxidized lipids as biomarkers and are advancing this approach toward clinical application. In this review, we will highlight the development of breath markers associated with ferroptosis and discuss the broader potential of breath-based technologies for monitoring disease-related metabolism.
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BibTeX
@article{matsuoka2026volatile,
title = {{Volatile Biomarkers in Exhaled Breath for In Vivo Lipid Peroxidation and Ferroptosis Detection}},
author = {Yuta Matsuoka},
journal = {Journal of Oleo Science},
year = {2026},
month = aug,
doi = {10.5650/jos.ess26082},
url = {https://www.jstage.jst.go.jp/article/jos/75/8/75_jos.ess26082/_article},
note = {CC BY},
}
RIS
TY - JOUR
TI - Volatile Biomarkers in Exhaled Breath for In Vivo Lipid Peroxidation and Ferroptosis Detection
AU - Yuta Matsuoka
PY - 2026
DA - 2026/08/01
JO - Journal of Oleo Science
DO - 10.5650/jos.ess26082
UR - https://www.jstage.jst.go.jp/article/jos/75/8/75_jos.ess26082/_article
AB - Human breath volatile metabolites have attracted increasing attention as a source of non-invasive biomarkers. However, the biosynthetic pathways of most breath-borne compounds remain unclear, and their relationships to physiological or pathological states are still poorly defined, which has greatly hindered the clini cal application of breath biomarkers.Ferroptosis is an iron-dependent process driven by lipid peroxidation that exacerbates tissue inflammation and has been implicated in a wide range of age-associated disorders. Importantly, some oxidized lipids generated during ferroptosis are volatile and can be released in exhaled breath. Based on this principle, we have developed a non-invasive strategy for detecting deep-tissue ferroptosis using exhaled volatile oxidized lipids as biomarkers and are advancing this approach toward clinical application. In this review, we will highlight the development of breath markers associated with ferroptosis and discuss the broader potential of breath-based technologies for monitoring disease-related metabolism.
SN - 1347-3352
SN - 1345-8957
ER -