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Peer-reviewedCC BY 4.0Frontiers in Immunology

Pseudorabies virus as vaccine vectors for delivering foreign antigens: methodology and application

  • Xiao-Xiao Tian1,2,3
  • Yong-Bo Yang1,4
  • Tong-Qing An1,3
4 affiliations
  1. 1State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences
  2. 2China Animal Health and Epidemiology Center
  3. 3Heilongjiang Provincial Key Laboratory of Veterinary Immunology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences
  4. 4Heilongjiang Veterinary Biopharmaceutical Engineering Technology Research Center, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences
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Abstract

Pseudorabies virus (PRV) is the etiological agent of pseudorabies (PR). It belongs to the Herpesviridae family and has double-stranded linear DNA encoding more than 70 proteins. Many of these proteins are non-essential for viral replication and provide insertion sites for foreign genes to enable heterologous protein expression. PRV is a promising viral-vector platform for expressing foreign proteins and developing vaccines against multiple pathogens. However, no recombinant PRV-vectored vaccines are commercially available to date. Here, we summarize the biological characteristics of PRV, recombinant PRV construction methodology, foreign gene insertion sites and optimization, immune responses, and applications of recombinant PRV-vectored vaccines. This study provides insights into the development of PRV recombinant vaccines and the latest research progress, offering novel perspectives for advancing preventive medicine through vaccinology.

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Cite

BibTeXRIS
BibTeX
@article{tian2026pseudorabies,
  title = {{Pseudorabies virus as vaccine vectors for delivering foreign antigens: methodology and application}},
  author = {Xiao-Xiao Tian and Yong-Bo Yang and Tong-Qing An},
  journal = {Frontiers in Immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.1997723},
  url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1997723/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Pseudorabies virus as vaccine vectors for delivering foreign antigens: methodology and application
AU  - Xiao-Xiao Tian
AU  - Yong-Bo Yang
AU  - Tong-Qing An
PY  - 2026
DA  - 2026/10/29
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.1997723
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1997723/full
AB  - Pseudorabies virus (PRV) is the etiological agent of pseudorabies (PR). It belongs to the Herpesviridae family and has double-stranded linear DNA encoding more than 70 proteins. Many of these proteins are non-essential for viral replication and provide insertion sites for foreign genes to enable heterologous protein expression. PRV is a promising viral-vector platform for expressing foreign proteins and developing vaccines against multiple pathogens. However, no recombinant PRV-vectored vaccines are commercially available to date. Here, we summarize the biological characteristics of PRV, recombinant PRV construction methodology, foreign gene insertion sites and optimization, immune responses, and applications of recombinant PRV-vectored vaccines. This study provides insights into the development of PRV recombinant vaccines and the latest research progress, offering novel perspectives for advancing preventive medicine through vaccinology.
SN  - 1664-3224
ER  -