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Peer-reviewedCC BY-NC-NDBMC infectious diseases

TyG index and TyG-WHtR as predictors of all-cause mortality in patients with prior hepatitis A or B virus infections.

  • Fan Bai1
  • Wen Li2
  • Ni Luo2
  • Yange Li2
  1. 1Department of Infectious Disease, XiJing 986 Hospital, Air Force Medical University, Xi'an, Shaanxi Province, 710054, P.R. China. [email protected].
  2. 2Department of Infectious Disease, XiJing 986 Hospital, Air Force Medical University, Xi'an, Shaanxi Province, 710054, P.R. China.
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Abstract

Objective

This study aims to investigate the association between the triglyceride glucose (TyG) index and the TyG-to-waist-height ratio (TyG-WHtR) with the risk of all-cause mortality in patients with prior hepatitis A virus (HAV) or hepatitis B virus (HBV) infection.Method

This study was a retrospective cohort study that included patients from 1999 to 2018 with available data on HAV/HBV, TyG-related indices, and survival and mortality information. Multiple imputation methods were utilized to address missing variables. A weighted multivariable Cox regression model was employed to analyze the relationship between TyG and TyG-WHtR with all-cause mortality in the study patients. Subgroup analyses were conducted based on age, gender, smoking, diabetes, cardiovascular disease, and hypertension. All analysis results were presented as hazards with a 95% confidence interval (CI).Results

The study included a total of 6,413 patients, of which 1,692 were dead. The follow-up period concluded in December 2019, with a total duration of 119.31 ± 1.53 months. Analysis revealed that in patients with prior HAV or HBV infection, the TyG (HR: 1.22, 95%CI: 1.10-1.36) and TyG-WHtR (HR: 1.53, 95%CI: 1.34-1.75) were associated with an increased risk of all-cause mortality. Separate studies conducted in patients with prior HAV or HBV infection also demonstrated an association between the TyG and TyG-WHtR indices with all-cause mortality (former: HR: 1.20, 95%CI: 1.07-1.34; latter: HR: 2.02, 95%CI: 1.49-2.74). Subgroup analysis results indicated that the association between TyG-WHtR and all-cause mortality was similar across age, gender, smoking, and hypertension groups (all P < 0.05).Conclusion

In patients with prior HAV or HBV infection, the TyG and TyG-WHtR indices were associated with an increased risk of all-cause mortality. This study underscores the importance of the TyG and TyG-WHtR for patients with prior viral hepatitis, potentially aiding in the improvement of health management for this group.Clinical trial

Our research is not a clinical trial.Clinical trial number

not applicable.

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Cite

BibTeXRIS
BibTeX
@article{bai2026index,
  title = {{TyG index and TyG-WHtR as predictors of all-cause mortality in patients with prior hepatitis A or B virus infections.}},
  author = {Fan Bai and Wen Li and Ni Luo and Yange Li},
  journal = {BMC infectious diseases},
  year = {2026},
  month = jul,
  doi = {10.1186/s12879-026-14058-z},
  url = {https://europepmc.org/article/MED/42902183},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - TyG index and TyG-WHtR as predictors of all-cause mortality in patients with prior hepatitis A or B virus infections.
AU  - Fan Bai
AU  - Wen Li
AU  - Ni Luo
AU  - Yange Li
PY  - 2026
DA  - 2026/07/01
JO  - BMC infectious diseases
DO  - 10.1186/s12879-026-14058-z
UR  - https://europepmc.org/article/MED/42902183
AB  - Objective  This study aims to investigate the association between the triglyceride glucose (TyG) index and the TyG-to-waist-height ratio (TyG-WHtR) with the risk of all-cause mortality in patients with prior hepatitis A virus (HAV) or hepatitis B virus (HBV) infection.Method  This study was a retrospective cohort study that included patients from 1999 to 2018 with available data on HAV/HBV, TyG-related indices, and survival and mortality information. Multiple imputation methods were utilized to address missing variables. A weighted multivariable Cox regression model was employed to analyze the relationship between TyG and TyG-WHtR with all-cause mortality in the study patients. Subgroup analyses were conducted based on age, gender, smoking, diabetes, cardiovascular disease, and hypertension. All analysis results were presented as hazards with a 95% confidence interval (CI).Results  The study included a total of 6,413 patients, of which 1,692 were dead. The follow-up period concluded in December 2019, with a total duration of 119.31 ± 1.53 months. Analysis revealed that in patients with prior HAV or HBV infection, the TyG (HR: 1.22, 95%CI: 1.10-1.36) and TyG-WHtR (HR: 1.53, 95%CI: 1.34-1.75) were associated with an increased risk of all-cause mortality. Separate studies conducted in patients with prior HAV or HBV infection also demonstrated an association between the TyG and TyG-WHtR indices with all-cause mortality (former: HR: 1.20, 95%CI: 1.07-1.34; latter: HR: 2.02, 95%CI: 1.49-2.74). Subgroup analysis results indicated that the association between TyG-WHtR and all-cause mortality was similar across age, gender, smoking, and hypertension groups (all P < 0.05).Conclusion  In patients with prior HAV or HBV infection, the TyG and TyG-WHtR indices were associated with an increased risk of all-cause mortality. This study underscores the importance of the TyG and TyG-WHtR for patients with prior viral hepatitis, potentially aiding in the improvement of health management for this group.Clinical trial  Our research is not a clinical trial.Clinical trial number  not applicable.
SN  - 1471-2334
ER  -