Mercury(II) Coordination Compounds Based on Pyridine-2,5-Dicarboxylic Acid: Synthesis, Crystal Structure, Morphological Characterization, and Biological Activities.
5 affiliations
- 1Department of Chemistry Faculty of Nano and Bio Sciences and Technology Persian Gulf University Bushehr 75169 Iran pgu.ac.ir.
- 2Department of Biotechnology and Life Sciences University of Insubria Via Jean Henry Dunant, 3 21100 Varese Italy uninsubria.eu.
- 3The Persian Gulf Marine Biotechnology Research Center The Persian Gulf Biomedical Sciences Research Institute Bushehr University of Medical Sciences Bushehr Iran bpums.ac.ir.
- 4Shamim Beh Azma Technical Inspection Company Bushehr Iran.
- 5Institute of Low Temperature and Structure Research Polish Academy of Sciences Okólna 2 Str. 50-422 Wroclaw Poland pan.pl.
Abstract
This work reports the synthesis, spectroscopic characterization, structural investigation, and biological evaluation of two new mercury(II) coordination compounds, ([HL'][Hg(HL) (μ-Cl)₂])n (1) and ([LHg]₂(μ-HL″)₂(μ-Cl)₂Hg(H₂O)₃)·H₂O (2), with H₂L as 2,5-pyridinedicarboxylic acid, L' as 2,4-diaminopyrimidine, and HL″ as 2,4-diamino-6-hydroxypyrimidine. Single-crystal X-ray diffraction was employed to determine the crystal and molecular structures of the compounds, while other techniques such as FTIR, NMR, PXRD, FESEM, EDS, TGA, BET, DLS, and Zeta were applied to understand their composition and physicochemical properties. Structural analysis confirmed that compound (1) is a one-dimensional coordination polymer, which has been formed through μ-Cl bridges, while compound (2) consists of a supramolecular structure that is stabilized by hydrogen bonding and π-π stacking interactions. The extended crystal structures are formed through coordination and further stabilized by noncovalent interactions. Both mercury(II) coordination compounds exhibited notable in vitro antibacterial and cytotoxic activities, warranting further mechanistic and toxicological evaluation before any therapeutic extrapolation, given the well-documented systemic toxicity of mercury.
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BibTeX
@article{jamshidi2026mercuryii,
title = {{Mercury(II) Coordination Compounds Based on Pyridine-2,5-Dicarboxylic Acid: Synthesis, Crystal Structure, Morphological Characterization, and Biological Activities.}},
author = {Fatemeh Jamshidi and Khosro Mohammadi and Payam Hayati and Somayyeh Gharibi and Arezoo Khoradmehr and Zeinab Asen and Jan Janczak},
journal = {Bioinorganic chemistry and applications},
year = {2026},
month = oct,
doi = {10.1155/bca/3269865},
url = {https://europepmc.org/article/MED/42959712},
note = {CC BY},
}
RIS
TY - JOUR
TI - Mercury(II) Coordination Compounds Based on Pyridine-2,5-Dicarboxylic Acid: Synthesis, Crystal Structure, Morphological Characterization, and Biological Activities.
AU - Fatemeh Jamshidi
AU - Khosro Mohammadi
AU - Payam Hayati
AU - Somayyeh Gharibi
AU - Arezoo Khoradmehr
AU - Zeinab Asen
AU - Jan Janczak
PY - 2026
DA - 2026/10/29
JO - Bioinorganic chemistry and applications
DO - 10.1155/bca/3269865
UR - https://europepmc.org/article/MED/42959712
AB - This work reports the synthesis, spectroscopic characterization, structural investigation, and biological evaluation of two new mercury(II) coordination compounds, ([HL'][Hg(HL) (μ-Cl)₂])n (1) and ([LHg]₂(μ-HL″)₂(μ-Cl)₂Hg(H₂O)₃)·H₂O (2), with H₂L as 2,5-pyridinedicarboxylic acid, L' as 2,4-diaminopyrimidine, and HL″ as 2,4-diamino-6-hydroxypyrimidine. Single-crystal X-ray diffraction was employed to determine the crystal and molecular structures of the compounds, while other techniques such as FTIR, NMR, PXRD, FESEM, EDS, TGA, BET, DLS, and Zeta were applied to understand their composition and physicochemical properties. Structural analysis confirmed that compound (1) is a one-dimensional coordination polymer, which has been formed through μ-Cl bridges, while compound (2) consists of a supramolecular structure that is stabilized by hydrogen bonding and π-π stacking interactions. The extended crystal structures are formed through coordination and further stabilized by noncovalent interactions. Both mercury(II) coordination compounds exhibited notable in vitro antibacterial and cytotoxic activities, warranting further mechanistic and toxicological evaluation before any therapeutic extrapolation, given the well-documented systemic toxicity of mercury.
SN - 1565-3633
SN - 1687-479X
ER -