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Peer-reviewedCC BY 4.0Frontiers in Transplantation

Case Report: Portable hypothermic machine perfusion for interregional deceased-donor kidney sharing in Vietnam

  • Hiep Nhu Pham1
  • Xuan Thanh Nguyen1
  • Khanh Ngoc Tran2
  • Dung Duc Nguyen3
  • Anh Van Quoc Nguyen4
  • Kha Cong Le Bui2
  • Hung Ngoc Pham4
4 affiliations
  1. 1Department of Pediatric Surgery and Abdominal Emergency, Hue Central Hospital, Hue, Vietnam
  2. 2Department of Urology B, Hue Central Hospital, Hue, Vietnam
  3. 3Department of Thoracic and Cardiovascular Surgery, Hue Central Hospital, Hue, Vietnam
  4. 4Department of Urology A, Hue Central Hospital, Hue, Vietnam
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Abstract

Long-distance transportation can prolong cold ischemia and complicate the utilization of deceased-donor kidneys, particularly in geographically dispersed transplant systems. We report, to our knowledge, the first clinical implementation in Vietnam of portable hypothermic machine perfusion (HMP) during interregional kidney transport. A kidney from a 61-year-old expanded-criteria deceased donor was allocated to a 42-year-old man with end-stage renal disease who had been receiving hemodialysis for 2 years following failure of a previous kidney allograft. The graft was transported over 1,000 km by ground transfer and scheduled commercial flight and was preserved using a LifePort Kidney Transporter with KPS-1 solution under pressure-controlled HMP at 30 mmHg. Total cold ischemia time was 10 h 50 min. From HMP initiation to arrival, renal vascular resistance decreased from 1.68 to 0.44 mmHg/mL/min, while perfusate flow increased from 16 to 52 mL/min. Despite three separate renal arteries and a second warm ischemia time of 55 min, the graft produced urine immediately after reperfusion. The recipient required no dialysis during the first postoperative week and maintained stable graft function at 6 months, with a serum creatinine of 142 µmol/L and an estimated glomerular filtration rate of approximately 55 mL/min/1.73 m2. This case demonstrates the operational feasibility of portable HMP for long-distance, interregional deceased-donor kidney sharing in Vietnam.

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Cite

BibTeXRIS
BibTeX
@article{pham2026case,
  title = {{Case Report: Portable hypothermic machine perfusion for interregional deceased-donor kidney sharing in Vietnam}},
  author = {Hiep Nhu Pham and Xuan Thanh Nguyen and Khanh Ngoc Tran and Dung Duc Nguyen and Anh Van Quoc Nguyen and Kha Cong Le Bui and Hung Ngoc Pham},
  journal = {Frontiers in Transplantation},
  year = {2026},
  month = oct,
  doi = {10.3389/frtra.2026.1982759},
  url = {https://doi.org/10.3389/frtra.2026.1982759},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Case Report: Portable hypothermic machine perfusion for interregional deceased-donor kidney sharing in Vietnam
AU  - Hiep Nhu Pham
AU  - Xuan Thanh Nguyen
AU  - Khanh Ngoc Tran
AU  - Dung Duc Nguyen
AU  - Anh Van Quoc Nguyen
AU  - Kha Cong Le Bui
AU  - Hung Ngoc Pham
PY  - 2026
DA  - 2026/10/21
JO  - Frontiers in Transplantation
DO  - 10.3389/frtra.2026.1982759
UR  - https://doi.org/10.3389/frtra.2026.1982759
AB  - Long-distance transportation can prolong cold ischemia and complicate the utilization of deceased-donor kidneys, particularly in geographically dispersed transplant systems. We report, to our knowledge, the first clinical implementation in Vietnam of portable hypothermic machine perfusion (HMP) during interregional kidney transport. A kidney from a 61-year-old expanded-criteria deceased donor was allocated to a 42-year-old man with end-stage renal disease who had been receiving hemodialysis for 2 years following failure of a previous kidney allograft. The graft was transported over 1,000 km by ground transfer and scheduled commercial flight and was preserved using a LifePort Kidney Transporter with KPS-1 solution under pressure-controlled HMP at 30 mmHg. Total cold ischemia time was 10 h 50 min. From HMP initiation to arrival, renal vascular resistance decreased from 1.68 to 0.44 mmHg/mL/min, while perfusate flow increased from 16 to 52 mL/min. Despite three separate renal arteries and a second warm ischemia time of 55 min, the graft produced urine immediately after reperfusion. The recipient required no dialysis during the first postoperative week and maintained stable graft function at 6 months, with a serum creatinine of 142 µmol/L and an estimated glomerular filtration rate of approximately 55 mL/min/1.73 m2. This case demonstrates the operational feasibility of portable HMP for long-distance, interregional deceased-donor kidney sharing in Vietnam.
SN  - 2813-2440
ER  -