Comparison of postoperative outcomes of whole liver transplantation and split liver transplantation using the Comprehensive Complication Index®
- 1Department of Hepatopancreatobiliary Surgery, Ningbo Medical Centre Lihuili Hospital
Abstract
Background Liver transplantation (LT) is a complex procedure that results in multiple postoperative complications. Surgeons use the Clavien-Dindo classification (CDC) to evaluate the severity of complications; however, only a few studies have reported the use of the Comprehensive Complication Index® (CCI®) to evaluate complications associated with LT and split liver transplantation (SLT). This study explored the application of the CCI® to evaluate complications after whole liver transplantation (WLT) and SLT. Methods During this retrospective study, 244 WLT and 104 SLT recipients were enrolled between January 2016 and June 2023. The clinical characteristics and postoperative complications (at hospital discharge) of the WLT and SLT groups were evaluated and compared. Results The median in-hospital CCI® score was 43.9. A comparison of the WLT and SLT groups indicated no significant differences in CCI® scores (WLT, 44.2; SLT, 43.3; p = 0.716). The postoperative intensive care unit stay and length of the postoperative stay were strongly correlated with the CCI® score of the entire cohort and those of the SLT and WLT groups (all p < 0.001). The CDC and CCI® demonstrated a Spearman’s rank-order correlation of 0.838 (p < 0.001). Additionally, the proportion of female recipients was significantly higher in the SLT group (25.0% vs. 16.0; p = 0.048). The body mass index (p = 0.002), Child-Pugh grade C rate (p = 0.017), and median model for end-stage liver disease score (p = 0.008) were lower in the SLT group. Conclusions The CCI® is appropriate for evaluating postoperative complications of SLT and WLT.
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BibTeX
@article{shan2026comparison,
title = {{Comparison of postoperative outcomes of whole liver transplantation and split liver transplantation using the Comprehensive Complication Index®}},
author = {Yuying Shan and Xi Yu and Jing Huang and Jiongze Fang and Jiannan Sun and Yong Yang and Shuqi Mao and Shengdong Wu and Caide Lu},
journal = {BMC Gastroenterology},
year = {2026},
month = jul,
doi = {10.1186/s12876-026-05149-x},
url = {https://doi.org/10.1186/s12876-026-05149-x},
note = {CC BY},
}
RIS
TY - JOUR
TI - Comparison of postoperative outcomes of whole liver transplantation and split liver transplantation using the Comprehensive Complication Index®
AU - Yuying Shan
AU - Xi Yu
AU - Jing Huang
AU - Jiongze Fang
AU - Jiannan Sun
AU - Yong Yang
AU - Shuqi Mao
AU - Shengdong Wu
AU - Caide Lu
PY - 2026
DA - 2026/07/01
JO - BMC Gastroenterology
DO - 10.1186/s12876-026-05149-x
UR - https://doi.org/10.1186/s12876-026-05149-x
AB - Background Liver transplantation (LT) is a complex procedure that results in multiple postoperative complications. Surgeons use the Clavien-Dindo classification (CDC) to evaluate the severity of complications; however, only a few studies have reported the use of the Comprehensive Complication Index® (CCI®) to evaluate complications associated with LT and split liver transplantation (SLT). This study explored the application of the CCI® to evaluate complications after whole liver transplantation (WLT) and SLT. Methods During this retrospective study, 244 WLT and 104 SLT recipients were enrolled between January 2016 and June 2023. The clinical characteristics and postoperative complications (at hospital discharge) of the WLT and SLT groups were evaluated and compared. Results The median in-hospital CCI® score was 43.9. A comparison of the WLT and SLT groups indicated no significant differences in CCI® scores (WLT, 44.2; SLT, 43.3; p = 0.716). The postoperative intensive care unit stay and length of the postoperative stay were strongly correlated with the CCI® score of the entire cohort and those of the SLT and WLT groups (all p < 0.001). The CDC and CCI® demonstrated a Spearman’s rank-order correlation of 0.838 (p < 0.001). Additionally, the proportion of female recipients was significantly higher in the SLT group (25.0% vs. 16.0; p = 0.048). The body mass index (p = 0.002), Child-Pugh grade C rate (p = 0.017), and median model for end-stage liver disease score (p = 0.008) were lower in the SLT group. Conclusions The CCI® is appropriate for evaluating postoperative complications of SLT and WLT.
SN - 1471-230X
ER -