Triple Total Coronary Occlusions in a Young Adult: Looking Beyond Conventional Atherosclerotic Risk Factors
- 1Hospital Medicine, Manchester University NHS Foundation Trust, Manchester, GBR
- 2General Internal Medicine, Manchester University NHS Foundation Trust, Manchester, GBR
- 3Cardiology, Manchester University NHS Foundation Trust, Manchester, GBR
Abstract
Severe coronary artery disease is uncommon in young adults, particularly when conventional cardiovascular risk factors are limited. We describe a 26-year-old man who presented with exertional chest pain and was found to have total occlusions affecting all three major coronary arteries. Extensive investigation for inherited, metabolic, autoimmune, and inflammatory causes did not identify a definitive aetiology. His history of heavy electronic-cigarette use and a prolonged febrile illness in childhood were considered potentially relevant but could not be established as causal. He ultimately underwent successful three-vessel coronary artery bypass grafting. This case highlights the importance of investigating unusual causes of severe premature coronary disease while avoiding over-attribution to unconfirmed risk factors.
Related
- The association between albuminuria and coronary atherosclerotic burden in the general population
- The role of coronary lipid burden in immediate atherosclerotic non-culprit plaque regression following acute coronary syndrome☆ : A post-hoc analysis of the FITTER trial
- Minimally Invasive Coronary Artery Bypass Grafting (MICS-CABG) Versus Conventional Off-Pump Coronary Artery Bypass Grafting (OPCAB): A Single-Center Analysis of Early Outcomes and Institutional Experience
- Significant Associations of Achilles Tendon Thickness With Atherosclerotic Diseases and Atherosclerotic Risk Factors in Non-Familial Hypercholesterolemia Patients: A Cross-Sectional Study
- Cardiometabolic risk factors and Mediterranean diet adherence in patients with premature atherosclerotic cardiovascular disease in Iran
BibTeX
@article{naeem2026triple,
title = {{Triple Total Coronary Occlusions in a Young Adult: Looking Beyond Conventional Atherosclerotic Risk Factors}},
author = {Junaid Naeem and Naseema-Maria Begum and Faraz Amjad},
journal = {Cureus},
year = {2026},
month = nov,
doi = {10.7759/cureus.119030},
url = {https://europepmc.org/article/PMC/PMC13728758},
note = {CC BY},
}
RIS
TY - JOUR
TI - Triple Total Coronary Occlusions in a Young Adult: Looking Beyond Conventional Atherosclerotic Risk Factors
AU - Junaid Naeem
AU - Naseema-Maria Begum
AU - Faraz Amjad
PY - 2026
DA - 2026/11/02
JO - Cureus
DO - 10.7759/cureus.119030
UR - https://europepmc.org/article/PMC/PMC13728758
AB - Severe coronary artery disease is uncommon in young adults, particularly when conventional cardiovascular risk factors are limited. We describe a 26-year-old man who presented with exertional chest pain and was found to have total occlusions affecting all three major coronary arteries. Extensive investigation for inherited, metabolic, autoimmune, and inflammatory causes did not identify a definitive aetiology. His history of heavy electronic-cigarette use and a prolonged febrile illness in childhood were considered potentially relevant but could not be established as causal. He ultimately underwent successful three-vessel coronary artery bypass grafting. This case highlights the importance of investigating unusual causes of severe premature coronary disease while avoiding over-attribution to unconfirmed risk factors.
SN - 2168-8184
ER -