Programmable Assembly of DNA Tetrahedra Bearing Atomically Precise Gold Nanoclusters: Stoichiometric Control and Molecular-Level Characterization
Abstract
Atomically precise gold nanoclusters (AuNCs) are ultra-small particles composed of ten to hundreds gold atoms and exhibit unique photophysical properties. Significant progress has been made in tuning and extending their luminescence in the near-infrared window through the design of AuNC assemblies. Herein, we report a straightforward method for synthesizing highly pure, programmable DNA tetrahedra functionalized with a controlled number of AuNCs (from one up to four AuNCs). Using ligand exchange chemistry, AuNCs bearing a single grafted ssDNA onto them were produced. These constructs then served as building blocks for synthesizing tetrahedra through DNA hybridization. Products obtained at each stage of the synthesis were thoroughly characterized using a range of complementary technics. Notably, mass spectrometry in native mode provided novel insights into the accurate composition and stoichiometry of these architectures. This study paves the way for the synthesis and the characterization of a variety of new three-dimensional, DNA-guided AuNC assemblies that may serve as powerful theranostics and biophotonic tools.
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BibTeX
@misc{manceau2026programmable,
title = {{Programmable Assembly of DNA Tetrahedra Bearing Atomically Precise Gold Nanoclusters: Stoichiometric Control and Molecular-Level Characterization}},
author = {Mathilde Manceau and Abdallah Alhalabi and Christine Saint-Pierre and Elisabetta Boeri-Erba and Xavier Le Guével and Didier Gasparutto},
howpublished = {HAL},
year = {2026},
month = jun,
doi = {10.64898/2026.06.06.730428},
url = {https://univ-grenoble-alpes.hal.science/hal-05785400v1},
note = {CC BY 4.0},
}
RIS
TY - UNPB
TI - Programmable Assembly of DNA Tetrahedra Bearing Atomically Precise Gold Nanoclusters: Stoichiometric Control and Molecular-Level Characterization
AU - Mathilde Manceau
AU - Abdallah Alhalabi
AU - Christine Saint-Pierre
AU - Elisabetta Boeri-Erba
AU - Xavier Le Guével
AU - Didier Gasparutto
PY - 2026
DA - 2026/06/09
PB - HAL
DO - 10.64898/2026.06.06.730428
UR - https://univ-grenoble-alpes.hal.science/hal-05785400v1
AB - Atomically precise gold nanoclusters (AuNCs) are ultra-small particles composed of ten to hundreds gold atoms and exhibit unique photophysical properties. Significant progress has been made in tuning and extending their luminescence in the near-infrared window through the design of AuNC assemblies. Herein, we report a straightforward method for synthesizing highly pure, programmable DNA tetrahedra functionalized with a controlled number of AuNCs (from one up to four AuNCs). Using ligand exchange chemistry, AuNCs bearing a single grafted ssDNA onto them were produced. These constructs then served as building blocks for synthesizing tetrahedra through DNA hybridization. Products obtained at each stage of the synthesis were thoroughly characterized using a range of complementary technics. Notably, mass spectrometry in native mode provided novel insights into the accurate composition and stoichiometry of these architectures. This study paves the way for the synthesis and the characterization of a variety of new three-dimensional, DNA-guided AuNC assemblies that may serve as powerful theranostics and biophotonic tools.
ER -